Venous resection during pancreatectomy for pancreatic cancer: a systematic review
Venous resection during pancreatectomy for pancreatic cancer: a systematic review
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Tarih
2019-01-01
Yazarlar
Wang, Xiaobo
Demir, Ihsan Ekin
Schorn, Stephan
Jaeger, Carsten
Scheufele, Florian
Friess, Helmut
Ceyhan, Guralp O.
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
AME PUBLISHING COMPANY
Dergi Adı
TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
Özet
Pancreatic cancer is one of the most aggressive and lethal malignancies with a dismal prognosis and survival. The curative effects of venous resection (VR) in pancreatic cancer remain controversial. A systematic literature search was performed in PubMed, Embase and the Cochrane Library. The overall postoperative complications, perioperative mortality, histopathology, and long-term survival were compared between patients undergoing pancreatectomy combined with (VR+ group) or without (VR- group) VR. Forty-one studies were included in the systematic review. Pancreatectomy combined with VR required longer operation time and led to increased perioperative blood loss, whereas postoperative complications were similar. Patients in the VR+ group showed larger tumors and reduced R0 rates. Regarding long-term survival, patients with VR+ seemed to have impaired 1-, 3-, and 5-year survival. Based on our results, VR in pancreatic cancer is a safe and feasible procedure. Given the fact that patients have miserable outcomes and survival in the palliative setting alone, extended resection including VR is required for the purpose of achieving radical resection.
Açıklama
Anahtar kelimeler
Pancreatectomy, pancreatic cancer, systematic review, venous resection (VR)