Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia
dc.contributor.author | Sanli, Deniz Esin Tekcan | |
dc.contributor.author | Altundag, Aytug | |
dc.contributor.author | Kandemirli, Sedat Giray | |
dc.contributor.author | Yildirim, Duzgun | |
dc.contributor.author | Sanli, Ahmet Necati | |
dc.contributor.author | Saatci, Ozlem | |
dc.contributor.author | Kirisoglu, Ceyda Erel | |
dc.contributor.author | Dikensoy, Oner | |
dc.contributor.author | Murrja, Edvin | |
dc.contributor.author | Yesil, Atakan | |
dc.contributor.author | Bastan, Serdar | |
dc.contributor.author | Karsidag, Tamer | |
dc.contributor.author | Akinci, Ibrahim Ozkan | |
dc.contributor.author | Ozkok, Sezen | |
dc.contributor.author | Yilmaz, Eren | |
dc.contributor.author | Tuzuner, Filiz | |
dc.contributor.author | Kilercik, Meltem | |
dc.contributor.author | Ljama, Taner | |
dc.date.accessioned | 2023-02-21T12:40:04Z | |
dc.date.available | 2023-02-21T12:40:04Z | |
dc.date.issued | 2021-01-01 | |
dc.description.abstract | Background: An association between IL-6 levels and cytokine storm syndrome in COVID-19 patients has been suggested. Cases with higher IL-6 levels have more rapid progression and a higher complication rate. On the other hand, COVID-19 cases with anosmia have a milder course of the disease. Objective: We aimed to investigate whether there is a relationship between serum IL-6 levels and presence of anosmia in COVID-19 patients. Methods: Patients with a confirmed diagnosis of COVID-19 based on laboratory (PCR) were stratified into two groups based on presence of olfactory dysfunction (OD). In all cases with and without anosmia | |
dc.description.abstract | psychophysical test (Sniffin' Sticks test) and a survey on olfactory symptoms were obtained. Threshold (t) - discrimination (d) - identification (i), and total (TDI) scores reflecting olfactory function were calculated. Clinical symptoms, serum IL-6 levels, other laboratory parameters, and chest computed tomography (CT) findings were recorded. Results: A total of 59 patients were included, comprising 23 patients with anosmia and 36 patients without OD based on TDI scores. Patients with anosmia (41.39 +/- 15.04) were significantly younger compared to cases without anosmia (52.19 +/- 18.50). There was no significant difference between the groups in terms of comorbidities, smoking history, and symptoms including nasal congestion and rhinorrhea. Although serum IL-6 levels of all patients were above normal values (7 pg/mL), patients with anosmia had significantly lower serum IL-6 levels (16.72 +/- 14.28 pg/mL) compared to patients without OD (60.95 +/- 89.33 pg/mL) (p = 0.026). Conclusion: Patients with COVID-19 related anosmia tend to have significantly lower serum levels of IL-6 compared to patients without OD, and the lower IL-6 levels is related to milder course of the disease. With the effect of low cytokine storm and IL-6 level, it may be said that anosmic cases have a milder disease in COVID-19. | |
dc.description.issue | 1 | |
dc.description.issue | JAN-FEB | |
dc.description.volume | 42 | |
dc.identifier.doi | 10.1016/j.amjoto.2020.102796 | |
dc.identifier.uri | https://hdl.handle.net/11443/2576 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.amjoto.2020.102796 | |
dc.identifier.wos | WOS:000600420000015 | |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | |
dc.relation.ispartof | AMERICAN JOURNAL OF OTOLARYNGOLOGY | |
dc.subject | COVID-19 | |
dc.subject | Anosmia | |
dc.subject | IL-6 | |
dc.subject | Prognosis | |
dc.subject | Mild disease | |
dc.subject | Cytokine storm | |
dc.subject | Olfactory dysfunction | |
dc.subject | Sniffin' Sticks test | |
dc.subject | Threshold discrimination identification | |
dc.subject | Computed tomography | |
dc.title | Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia | |
dc.type | Article |
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