Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia

dc.contributor.authorSanli, Deniz Esin Tekcan
dc.contributor.authorAltundag, Aytug
dc.contributor.authorKandemirli, Sedat Giray
dc.contributor.authorYildirim, Duzgun
dc.contributor.authorSanli, Ahmet Necati
dc.contributor.authorSaatci, Ozlem
dc.contributor.authorKirisoglu, Ceyda Erel
dc.contributor.authorDikensoy, Oner
dc.contributor.authorMurrja, Edvin
dc.contributor.authorYesil, Atakan
dc.contributor.authorBastan, Serdar
dc.contributor.authorKarsidag, Tamer
dc.contributor.authorAkinci, Ibrahim Ozkan
dc.contributor.authorOzkok, Sezen
dc.contributor.authorYilmaz, Eren
dc.contributor.authorTuzuner, Filiz
dc.contributor.authorKilercik, Meltem
dc.contributor.authorLjama, Taner
dc.date.accessioned2023-02-21T12:40:04Z
dc.date.available2023-02-21T12:40:04Z
dc.date.issued2021-01-01
dc.description.abstractBackground: An association between IL-6 levels and cytokine storm syndrome in COVID-19 patients has been suggested. Cases with higher IL-6 levels have more rapid progression and a higher complication rate. On the other hand, COVID-19 cases with anosmia have a milder course of the disease. Objective: We aimed to investigate whether there is a relationship between serum IL-6 levels and presence of anosmia in COVID-19 patients. Methods: Patients with a confirmed diagnosis of COVID-19 based on laboratory (PCR) were stratified into two groups based on presence of olfactory dysfunction (OD). In all cases with and without anosmia
dc.description.abstractpsychophysical test (Sniffin' Sticks test) and a survey on olfactory symptoms were obtained. Threshold (t) - discrimination (d) - identification (i), and total (TDI) scores reflecting olfactory function were calculated. Clinical symptoms, serum IL-6 levels, other laboratory parameters, and chest computed tomography (CT) findings were recorded. Results: A total of 59 patients were included, comprising 23 patients with anosmia and 36 patients without OD based on TDI scores. Patients with anosmia (41.39 +/- 15.04) were significantly younger compared to cases without anosmia (52.19 +/- 18.50). There was no significant difference between the groups in terms of comorbidities, smoking history, and symptoms including nasal congestion and rhinorrhea. Although serum IL-6 levels of all patients were above normal values (7 pg/mL), patients with anosmia had significantly lower serum IL-6 levels (16.72 +/- 14.28 pg/mL) compared to patients without OD (60.95 +/- 89.33 pg/mL) (p = 0.026). Conclusion: Patients with COVID-19 related anosmia tend to have significantly lower serum levels of IL-6 compared to patients without OD, and the lower IL-6 levels is related to milder course of the disease. With the effect of low cytokine storm and IL-6 level, it may be said that anosmic cases have a milder disease in COVID-19.
dc.description.issue1
dc.description.issueJAN-FEB
dc.description.volume42
dc.identifier.doi10.1016/j.amjoto.2020.102796
dc.identifier.urihttps://hdl.handle.net/11443/2576
dc.identifier.urihttp://dx.doi.org/10.1016/j.amjoto.2020.102796
dc.identifier.wosWOS:000600420000015
dc.publisherW B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartofAMERICAN JOURNAL OF OTOLARYNGOLOGY
dc.subjectCOVID-19
dc.subjectAnosmia
dc.subjectIL-6
dc.subjectPrognosis
dc.subjectMild disease
dc.subjectCytokine storm
dc.subjectOlfactory dysfunction
dc.subjectSniffin' Sticks test
dc.subjectThreshold discrimination identification
dc.subjectComputed tomography
dc.titleRelationship between disease severity and serum IL-6 levels in COVID-19 anosmia
dc.typeArticle

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