Plasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus

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dc.contributor.authorBabalik, Aylin
dc.contributor.authorUlus, Ismail Hakki
dc.contributor.authorBakirci, Nadi
dc.contributor.authorKuyucu, Tulin
dc.contributor.authorArpag, Huseyin
dc.contributor.authorDagyildizi, Lale
dc.contributor.authorCapaner, Esen
dc.date.accessioned2023-02-21T12:34:29Z
dc.date.available2023-02-21T12:34:29Z
dc.date.issued2013-01-01
dc.description.abstractPlasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50\% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49\% or 100\% (P < 0.01), 66\% or 100\% (P < 0.05), 30\% or 50\% (P = 0.198), and 32\% or 21\% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.
dc.description.issue11
dc.description.issueNOV
dc.description.pages5740-5742
dc.description.volume57
dc.identifier.doi10.1128/AAC.01345-13
dc.identifier.urihttps://hdl.handle.net/11443/1755
dc.identifier.urihttp://dx.doi.org/10.1128/AAC.01345-13
dc.identifier.wosWOS:000325764000076
dc.publisherAMER SOC MICROBIOLOGY
dc.relation.ispartofANTIMICROBIAL AGENTS AND CHEMOTHERAPY
dc.titlePlasma Concentrations of Isoniazid and Rifampin Are Decreased in Adult Pulmonary Tuberculosis Patients with Diabetes Mellitus
dc.typeArticle

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