Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
dc.contributor.author | Uysal, Pelin | |
dc.contributor.author | Afsar, Cigdem Usul | |
dc.contributor.author | Sozer, Volkan | |
dc.contributor.author | Inanc, Berrin | |
dc.contributor.author | Agaoglu, Fulya | |
dc.contributor.author | Gural, Zeynep | |
dc.contributor.author | Fazlioglu, Nevin Gural | |
dc.contributor.author | Cuhadaroglu, Caglar | |
dc.contributor.author | Uzun, Hafize | |
dc.date.accessioned | 2023-02-21T12:38:51Z | |
dc.date.available | 2023-02-21T12:38:51Z | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | Background: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods: This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results: Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 <plus/minus> 0.40 g/dL, 0.38 +/- 0.20) when compared with its baseline levels (3.40 +/- 0.55 g/dL,P < 0.001 | |
dc.description.abstract | 0.86 <plus/minus> 0.71,P < 0.001, respectively). Serum C-reactive protein levels were significantly increased after CRT (7.49 <plus/minus> 6.53 mg/L) when compared with its baseline levels (9.54 +/- 3.80 mg/L,P = 0.038). After RT, ghrelin levels in patients were positively correlated with body mass index (r = 0.830,P < 0.001) and albumin (r = 0.758,P < 0.001). Conclusion: Ghrelin may play a role in the pathogenesis of weight loss in NSCLC patients. Ghrelin seems to be implicated in cancer-related weight loss. Ghrelin, cancer, and RT all together have a role in tumor-related anorexia-cachexia in patients with NSCLC. Results of this study need further evaluation as regards to its potential role as an adjuvant diagnostic or prognostic marker. | |
dc.description.issue | 4 | |
dc.description.issue | JUL-SEP | |
dc.description.pages | 855-859 | |
dc.description.volume | 16 | |
dc.identifier.doi | 10.4103/jcrt.JCRT_10_19 | |
dc.identifier.uri | https://hdl.handle.net/11443/2436 | |
dc.identifier.uri | http://dx.doi.org/10.4103/jcrt.JCRT_10_19 | |
dc.identifier.wos | WOS:000585412200025 | |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | |
dc.relation.ispartof | JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | |
dc.subject | Cancer cachexia | |
dc.subject | chemoradiotherapy | |
dc.subject | ghrelin | |
dc.subject | locally advanced nonsmall cell lung cancer | |
dc.title | Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy | |
dc.type | Article |
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