Poor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahceehir (Istanbul) Breast Cancer Screening Project in Turkey

dc.contributor.authorCabioglu, Neslihan
dc.contributor.authorGuerdal, Sibel OEzkan
dc.contributor.authorKayhan, Arda
dc.contributor.authorOEzaydin, Niluefer
dc.contributor.authorSahin, Cennet
dc.contributor.authorCan, OEmuer
dc.contributor.authorOEzcinar, Beyza
dc.contributor.authorAykuter, Goenuel
dc.contributor.authorVatandas, Guelcin
dc.contributor.authorAribal, Erkin
dc.contributor.authorOEzmen, Vahit
dc.date.accessioned2023-02-21T12:39:08Z
dc.date.available2023-02-21T12:39:08Z
dc.date.issued2020-01-01
dc.description.abstractPURPOSE The Turkish Bahceehir Breast Cancer Screening Project was a 10-year, organized, population-based screening program carried out in Bahceehir county, Istanbul. Our aim was to examine the biologic features and outcome of screen-detected and interval breast cancers during the 10-year study period. METHODS Between 2009 and 2019, 2-view mammograms were obtained at 2-year intervals for women aged 40 to 69 years. Clinicopathological characteristics including ER, PR, HER2-neu, and Ki-67 status were analyzed for those diagnosed with breast cancer. RESULTS In 8,758 screened women, 131 breast cancers (1.5\%) were detected. The majority of patients (82.3\%) had prognostic stage 0-I disease. Contrarily, patients with interval cancers (n = 15
dc.description.abstract11.4\%) were more likely to have a worse prognostic stage (II-IV disease
dc.description.abstractodds ratio {[}OR], 3.59, 95\% CI, 0.9 to 14.5) and high Ki-67 scores (OR, 3.14
dc.description.abstract95\% CI, 0.9 to 11.2). Interval cancers detected within 1 year were more likely to have a luminal B (57.1\% v 31.9\%) and triple-negative (14.3\% v 1\%) subtype and less likely to have a luminal A subtype (28.6\% v 61.5\%
dc.description.abstractP = .04). Patients with interval cancers had a poor outcome in 10-year disease-specific (DSS) and disease-free survival (DFS) compared with those with screen-detected cancers (DSS: 68.2\% v 98.1\%, P = .002
dc.description.abstractDFS: 78.6\% v 96.5\%, P = .011). CONCLUSION Our findings suggest the majority of screen-detected breast cancers exhibited a luminal A subtype profile with an excellent prognosis. However, interval cancers were more likely to have aggressive subtypes such as luminal B subtype or triple-negative cancers associated with a poor prognosis requiring other preventive strategies. (c) 2020 by American Society of Clinical Oncology
dc.description.issueJUN
dc.description.pages1103-1113
dc.description.volume6
dc.identifier.doi10.1200/GO.20.00145
dc.identifier.urihttps://hdl.handle.net/11443/2472
dc.identifier.urihttp://dx.doi.org/10.1200/GO.20.00145
dc.identifier.wosWOS:000564861600023
dc.publisherAMER SOC CLINICAL ONCOLOGY
dc.relation.ispartofJCO GLOBAL ONCOLOGY
dc.titlePoor Biological Factors and Prognosis of Interval Breast Cancers: Long-Term Results of Bahceehir (Istanbul) Breast Cancer Screening Project in Turkey
dc.typeArticle

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