Could the Long-Term Oncological Safety of Laparoscopic Surgery in Low-Risk Endometrial Cancer also Be Valid for the High-Intermediate- and High-Risk Patients? A Multi-Center Turkish Gynecologic Oncology Group Study Conducted with 2745 Endometrial Cancer Cases. (TRSGO-End-001)

dc.contributor.authorVardar, Mehmet Ali
dc.contributor.authorGuzel, Ahmet Baris
dc.contributor.authorTaskin, Salih
dc.contributor.authorGungor, Mete
dc.contributor.authorOzgul, Nejat
dc.contributor.authorSalman, Coskun
dc.contributor.authorKucukgoz-Gulec, Umran
dc.contributor.authorKhatib, Ghanim
dc.contributor.authorTaskiran, Cagatay
dc.contributor.authorDuender, Ilkkan
dc.contributor.authorOrtac, Firat
dc.contributor.authorYuce, Kunter
dc.contributor.authorTerek, Cosan
dc.contributor.authorSimsek, Tayup
dc.contributor.authorOzsaran, Aydin
dc.contributor.authorOnan, Anil
dc.contributor.authorCoban, Gonca
dc.contributor.authorTopuz, Samet
dc.contributor.authorDemirkiran, Fuat
dc.contributor.authorTakmaz, Ozguc
dc.contributor.authorKose, M. Faruk
dc.contributor.authorGocmen, Ahmet
dc.contributor.authorSeydaoglu, Gulsah
dc.contributor.authorGumurdulu, Derya
dc.contributor.authorAyhan, Ali
dc.date.accessioned2023-02-21T12:41:31Z
dc.date.available2023-02-21T12:41:31Z
dc.date.issued2021-01-01
dc.description.abstractThis study was conducted to compare the long-term oncological outcomes of laparotomy and laparoscopic surgeries in endometrial cancer under the light of the 2016 ESMO-ESGO-ESTRO risk classification system, with particular focus on the high-intermediate- and high-risk categories. Using multicentric databases between January 2005 and January 2016, disease-free and overall survivals of 2745 endometrial cancer cases were compared according to the surgery route (laparotomy vs. laparoscopy). The high-intermediate- and high-risk patients were defined with respect to the 2016 ESMO-ESGO-ESTRO risk classification system, and they were analyzed with respect to differences in survival rates. Of the 2745 patients, 1743 (63.5\%) were operated by laparotomy, and the remaining were operated with laparoscopy. The total numbers of high-intermediate- and high-risk endometrial cancer cases were 734 (45\%) patients in the laparotomy group and 307 (30.7\%) patients in the laparoscopy group. Disease-free and overall survivals were not statistically different when compared between laparoscopy and laparotomy groups in terms of low-, intermediate-, high-intermediate- and high-risk endometrial cancer. In conclusion, regardless of the endometrial cancer risk category, long-term oncological outcomes of the laparoscopic approach were found to be comparable to those treated with laparotomy. Our results are encouraging to consider laparoscopic surgery for high-intermediate- and high-risk endometrial cancer cases.
dc.description.issue6
dc.description.issueDEC
dc.description.pages4328-4340
dc.description.volume28
dc.identifier.doi10.3390/curroncol28060368
dc.identifier.urihttps://hdl.handle.net/11443/2727
dc.identifier.urihttp://dx.doi.org/10.3390/curroncol28060368
dc.identifier.wosWOS:000747043700001
dc.publisherMDPI
dc.relation.ispartofCURRENT ONCOLOGY
dc.subjecthigh-risk endometrial cancer
dc.subjectlaparoscopic surgery
dc.subjectsurvival
dc.titleCould the Long-Term Oncological Safety of Laparoscopic Surgery in Low-Risk Endometrial Cancer also Be Valid for the High-Intermediate- and High-Risk Patients? A Multi-Center Turkish Gynecologic Oncology Group Study Conducted with 2745 Endometrial Cancer Cases. (TRSGO-End-001)
dc.typeArticle

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