COVID-19 vaccine candidates and vaccine development platforms available worldwide

dc.contributor.authorDuman, Nilgun
dc.contributor.authorALzaidi, Zahraa
dc.contributor.authorAynekin, Busra
dc.contributor.authorTaskin, Duygu
dc.contributor.authorDemirors, Busra
dc.contributor.authorYildirim, Abdulbaki
dc.contributor.authorSahin, Izem Olcay
dc.contributor.authorBilgili, Faik
dc.contributor.authorTuranli, Eda Tahir
dc.contributor.authorBeccari, Tommaso
dc.contributor.authorBertelli, Matteo
dc.contributor.authorDundar, Munis
dc.date.accessioned2023-02-21T12:39:06Z
dc.date.available2023-02-21T12:39:06Z
dc.date.issued2021-01-01
dc.description.abstractThe pandemic caused by the worldwide spread of the coronavirus, which first appeared in 2019, has been named coronavirus disease 19 (COVID-19). More than 4.5 million deaths have been recorded due to the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to the World Health Organization. COVID-19 Dashboard in September 2021. Apart from the wildtype, other variations have been successfully transmitted early in the outbreak although they were not discovered until March 2020. Modifications in the SARS-CoV-2 genetic material, such as mutation and recombi-nation, have the ability to modify the viral life span, along with transitivity, cellular tropism, and symptom severity. Several processes are involved in introducing novel vaccines to the population, including vaccine manufacturing, preclinical studies, Food and Drug Administration permission or cer-tification, processing, and marketing. COVID-19 vaccine candidates have been developed by a number of public and private groups employing a variety of strategies, such as RNA, DNA, protein, and viral vectored vaccines. This comprehensive review, which included the most subsequent evidence on unique features of SARS-CoV-2 and the associated morbidity and mortality, was carried out using a systematic search of recent online databases in order to generate useful knowledge about the COVID-19 updated versions and their consequences on the disease symptoms and vaccine development. (c) 2021 Xi'an Jiaotong University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.issue6
dc.description.issueDEC
dc.description.pages675-682
dc.description.volume11
dc.identifier.doi10.1016/j.jpha.2021.09.004
dc.identifier.urihttps://hdl.handle.net/11443/2468
dc.identifier.urihttp://dx.doi.org/10.1016/j.jpha.2021.09.004
dc.identifier.wosWOS:000738315700001
dc.publisherELSEVIER
dc.relation.ispartofJOURNAL OF PHARMACEUTICAL ANALYSIS
dc.subjectCOVID-19 vaccine
dc.subjectVaccine development platform
dc.subjectCoronavirus outbreak
dc.subjectSARS-CoV-2 variants
dc.subjectTreatment
dc.titleCOVID-19 vaccine candidates and vaccine development platforms available worldwide
dc.typeArticle

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