ASSOCIATION OF E-SELECTIN S128R POLYMORPHISM WITH HEREDITARY BREAST CARCINOMA SUSCEPTIBILITY IN TURKISH PATIENTS WITHOUT BRCA1/2 GERMLINE MUTATIONS

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Tarih
2018-01-01
Yazarlar
Yararbas, K.
Atalay, P. B.
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
MACEDONIAN ACAD SCIENCES ARTS
Dergi Adı
BALKAN JOURNAL OF MEDICAL GENETICS
Özet
Inherited genetic factors play an important role in breast cancer susceptibility. The BRCA1 and BRCA2 mutations are the most well-known genetic factors associated with increased risk of breast cancer. E-selectin is a cell surface glycoprotein and its serum levels are known to increase in various cancers. The present retrospective study aimed to evaluate whether E-selectin S128R polymorphism (NG\_012124.1: g.7161A>C, NM\_000450.2: c.445A>C, NP\_000441.2: p.Ser149Arg), which is known to have a role in cancer risk, is associated with breast cancer susceptibility in BRCA1/2 mutation non carriers with breast cancer. The study included 90 patients with breast cancer and 270 healthy controls. All breast cancer patients were screened for BRCA1/2 mutations and confirmed to be BRCA 1/2 mutation non carriers before inclusion in the study. Genotyping for the E-selectin S128R polymorphism was performed using real-time polymerase chain reaction (PCR) analysis. The frequencies of the AA, AC and CC genotypes were 70.0, 25.5 and 4.5\%, respectively, in the patient group and 79.25, 19.25 and 1.5\%, respectively, in the controls. The frequencies of A and C alleles were 84.8 and 15.2\% in the patient group, respectively, and 88.9 and 11.1\%. respectively, in the controls. No significant differences were determined in the genotype and allele frequencies of the E-selectin S128R polymorphism between the patient and control groups (p = 0.095). The S128R (A/C) polymorphism was not found to be associated with an increased risk of breast cancer {[}odds ratio (OR) = 0.69
95\% confidence interval (95\% CI): 0.43-1.10
p = 0.1248). There was no association between the S128R polymorphism and breast cancer susceptibility in BRCA1/2 mutation non carriers with breast cancer in the studied Turkish population. Further studies with larger sample sizes are needed to validate our findings.
Açıklama
Anahtar kelimeler
Breast carcinoma, Cancer susceptibility, E-selectin, rs5361
Alıntı
Koleksiyonlar