Prognostic significance of primary tumor localization in stage II and III colon cancer
Prognostic significance of primary tumor localization in stage II and III colon cancer
Tarih
2018-01-01
Yazarlar
Sakin, Abdullah
Arici, Serdar
Secmeler, Saban
Can, Orcun
Geredeli, Caglayan
Yasar, Nurgul
Demir, Cumhur
Demir, Osman Gokhan
Cihan, Sener
Süreli Yayın başlığı
Süreli Yayın ISSN
Cilt Başlığı
Yayınevi
BAISHIDENG PUBLISHING GROUP INC
Dergi Adı
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Özet
AIM To investigate the effects of tumor localization on disease free survival (DFS) and overall survival (OS) in patients with stage I -III colon cancer. METHODS This retrospective study included 942 patients with stage. and. colon cancer, which were followed up in our clinics between 1995 and 2017. The tumors from the caecum to splenic flexure were defined as right colon cancer (RCC) and those from splenic flexure to the sigmoid colon as left colon cancer (LCC). RESULTS The median age of the patients was 58 years (range: 19-94 years). Male patients constituted 54.2\%. The rates of RCC and LCC were 48.4\% (n = 456) and 51.6\% (n = 486), respectively. During the median follow-up of 90 mo (range: 6-252 mo), 14.6\% of patients developed recurrence and 9.1\% of patients died. In patients with stage. and. disease with or without adjuvant therapy, DFS was similar in terms of primary tumor localization (stage.
P = 0.547 and P = 0.481, respectively
stage.
P = 0.976 and P = 0.978, respectively). In patients with stage. and. disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization (stage.
P = 0.381 and P = 0.947, respectively
stage.
P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC (26 +/- 6.2 mo) and LCC (34 +/- 4.(mo) cases was eight months (P = 0.092). CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage. or. colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients.
P = 0.547 and P = 0.481, respectively
stage.
P = 0.976 and P = 0.978, respectively). In patients with stage. and. disease with or without adjuvant therapy, OS was not statistically significant with respect to primary tumor localization (stage.
P = 0.381 and P = 0.947, respectively
stage.
P = 0.378 and P = 0.904, respectively). The difference between median OS of recurrent RCC (26 +/- 6.2 mo) and LCC (34 +/- 4.(mo) cases was eight months (P = 0.092). CONCLUSION Our study showed no association of tumor localization with either DFS or OS in patients with stage. or. colon cancer managed with or without adjuvant therapy. However, post-recurrence OS appeared to be worse in RCC patients.
Açıklama
Anahtar kelimeler
Colon cancer, Tumor localization, Adjuvant treatment, Overall survival, Disease free survival