Browsing by Author "Aserdar, Muhittin"

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    Clinical significance of plasma tryptophan, kynurenine, and kynurenine/tryptophan ratio in rheumatoid arthritis patients
    (ELSEVIER, 2022-01-01) Kor, Ahmet; Erten, Sukran; Yurt, Emine F.; Dogan, Ismail; Apaydin, Hakan; Aserdar, Muhittin; Bicer, Cemile
    Background: The catabolism of tryptophan (Trp) in the kynurenine (Kyn) pathway is thought to have a critical immunosuppressive effect.Aim of the work: To evaluate plasma Trp and metabolite levels to identify their diagnostic potential in rheumatoid arthritis (RA).Patients and methods: 50 RA patients and 41 control were included in this study. The Trp and Kyn were analyzed and the Kyn\textbackslash{}Trp ratio was calculated to estimate Indolamine 2,3 dioxygenase (IDO) enzyme activity involved in Trp degradation.Results: The 50 patients had a mean age of 58.5 +/- 10.6 years