Browsing by Author "Batukan, Cem"

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    Oral tadalafil reduces intra-abdominal adhesion reformation in rats
    (OXFORD UNIV PRESS, 2012-01-01) Kutuk, Mehmet Serdar; Ozgun, Mahmut Tuncay; Batukan, Cem; Ozcelik, Bulent; Basbug, Mustafa; Ozturk, Ahmet
    Currently, there is no ideal agent to prevent adhesion formation. We have shown that sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, reduces post-operative adhesion formation by vasodilatation and increases fibrinolytic activity. Here, we evaluated whether tadalafil, a long-acting PDE-5 inhibitor, decreases post-operative adhesion reformation in rats. Standardized lesions were created in Wistar albino rats by cauterization of uterine horns and abrasion of adjacent peritonium. The extent and severity of adhesions were scored on the 14th post-operative day and adhesiolysis was performed at the second laparotomy. Animals were then assigned randomly into two groups. The study group (n 11) received 10 mg/kg oral tadalafil by gavage 60 min before the second laparotomy and daily for 14 days afterwards. Controls (n 11) received the same volume of tap water for 14 days by gavage. Animals were killed 15 days after adhesiolysis and adhesions were scored blind during the third laparotomy. Basal adhesion scores at the time of the second laparotomy were comparable in the study and control groups. Scores for the extent of adhesion reformation in the study and control groups did not differ {[}median 1 (range 03) versus median 2 (range 13)
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    Symptoms and Health Quality After Laparoscopic and Robotic Myomectomy
    (SOC LAPAROENDOSCOPIC SURGEONS, 2018-01-01) Takmaz, Ozguc; Ozbasli, Esra; Gundogan, Savas; Bastu, Ercan; Batukan, Cem; Dede, Suat; Gungor, Mete
    Background and Objectives: To compare the symptom severity and health quality outcomes of women who underwent laparoscopic and robotic myomectomy. Methods: This was a prospective nonrandomized cohort study. The Uterine Fibroid Symptom and Health Related Quality of Life Questionnaire was administered to 33 laparoscopic myomectomy and 31 robotic myomectomy patients before and year after surgery. Symptom severity and health quality scores were compared between the preoperative and postoperative periods for laparoscopic and robotic myomectomy procedures. Results: The mean age, operation time, estimated blood loss, body mass index, largest fibroid diameter, length of hospital stay, and number of fibroids removed were comparable for both groups (P > .05). Symptom severity scores decreased significantly for both laparoscopic and robotic myomectomy patients at year after surgery (P < .05), and health-related quality of life scores increased significantly in both groups at 1 year after surgery (P < .05). Improvement in symptom severity and health quality was higher in the laparoscopy group