Browsing by Author "Guzel, Elif"

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    Does Lapatinib Increase Pulmonary Toxicity when Concurrently Used with Radiation Therapy? An Experimental Study with Wistar-Albino Rats
    (AKAD DOKTORLAR YAYINEVI, 2018-01-01) Yetmen Dogan, Ozlem; Guzel, Elif; Coban, Ilker; Suzer, Oner; Bese, Nuran
    Lapatinib is an oral receptor tyrosine kinase inhibitor which has shown activity in the treatment of metastatic breast cancer. There is no data regarding the side effects of combination of radiotherapy and Lapatinib. 40 female Wistar-albino rats (WAR) were divided into 4 groups
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    Electron Microscopic Comparison of Radial Artery Grafts in Non-Diabetic and Diabetic Coronary Bypass Patients
    (WILEY, 2016-01-01) Gursoy, Mete; Guzel, Elif; Erturkuner, Pelin; Cakir, Idil; Duygu, Egemen; Gulcan, Fusun; Hokenek, A. Faruk
    Objective: We compared electron microscopic histologic changes of the radial artery grafts in non-diabetic and diabetic patients. Methods: Thirty-six patients were divided into three groups according to their diabetic status (Group I had no diabetes mellitus {[}DM], Group II had type two DM and HbA1c levels were <7.5\%, and Group III had type 2 DM but HbA1c levels were >7.5\%). Distal parts of radial artery grafts were evaluated with scanning electron microscopy in a blind fashion by two histologists. Electron microscopic scores were compared among the groups. Results: Radial artery electron microscopic scores were significantly different between group 1, 2 and 1, 3 and 2, 3 (p = 0.028, p<0.001, and p<0.001). In linear regression analysis, duration of DM (p = 0.027) and fasting plasma glucose (p = 0.001) were found as independent risk factors for histologic changes of radial artery grafts. Conclusion: Duration of DM and poor glycemic control were found to be associated with radial artery electron microscopic changes.