Browsing by Author "Oktem-Okullu, Sinem"

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    Analysis of Correlation between the Seven Important Helicobacter pylori (H. pylori) Virulence Factors and Drug Resistance in Patients with Gastritis
    (HINDAWI LTD, 2020-01-01) Oktem-Okullu, Sinem; Cekic-Kipritci, Zehra; Kilic, Elif; Seymen, Nogayhan; Mansur-Ozen, Nesteren; Sezerman, Ugur; Gurol, Yesim
    The aim of this study is to evaluate the association between seven importantH.pylorivirulence factors and antibiotic resistance in patients with gastritis.H.pyloristrains isolated from 33 patients with gastritis were examined. Antimicrobial susceptibilities were tested by GenoType (R) HelicoDR (Hain Life Science, Germany) test kit and RT-PCR. The virulence-factors were determined using conventional PCR. 39\% of patients were resistant for clarithromycin and 27\% of patients were resistant for fluoroquinolone. 15\% of patients were resistant to both clarithromycin and fluoroquinolone. TheH.pylori vacA m1/s2genotype was the most frequent allelic combination. Patients were possessed thevacA s1,m1(6.1\%)
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    Multiplex-PCR-Based Screening and Computational Modeling of Virulence Factors and T-Cell Mediated Immunity in Helicobacter pylori Infections for Accurate Clinical Diagnosis
    (PUBLIC LIBRARY SCIENCE, 2015-01-01) Oktem-Okullu, Sinem; Tiftikci, Arzu; Saruc, Murat; Cicek, Bahattin; Vardareli, Eser; Tozun, Nurdan; Kocagoz, Tanil; Sezerman, Ugur; Yavuz, Ahmet Sinan; Sayi-Yazgan, Ayca
    The outcome of H. pylori infection is closely related with bacteria's virulence factors and host immune response. The association between T cells and H. pylori infection has been identified, but the effects of the nine major H. pylori specific virulence factors