Browsing by Author "Yuksel, Selcen"

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Adult Spinal Deformity Over 70 Years of Age: A 2-Year Follow-Up Study
(INT SOC ADVANCEMENT SPINE SURGERY-ISASS, 2019-01-01) Karabulut, Cem; Ayhan, Selim; Yuksel, Selcen; Nabiyev, Vugar; Vila-Casademunt, Alba; Pellise, Ferran; Alanay, Ahmet; Sanchez Perez-Grueso, Francisco Javier; Kleinstuck, Frank; Obeid, Ibrahim; Acaroglu, Emre; Grp, European Spine Study
Background: Treatment of adult spinal deformity (ASD) in elderly patients remains controversial. The aim of this study was to identify the factors leading to the surgical treatment by comparing the baseline characteristics of operative versus nonoperative patients, to evaluate the safety and efficacy of surgery, and to compare operative and nonoperative management of elderly ASD patients at the end of the 2-year follow-up period. Methods: Retrospective review of a multicenter, prospective ASD database was performed. Patients over 70 years of age with ASD who were scheduled to undergo surgical treatment and who were treated and/or followed without surgical intervention participated in the study. Demographic, clinical, surgical, and radiological characteristics and health-related quality-of-life (HRQOL) (Core Outcome Measures Index {[}COMI], Oswestry Disability Index {[}ODI], Short-Form-36 Mental Component Summary {[}SF-36 MCS], Short-Form-36 Physical Component Summary {[}SF36-PCS], and Scoliosis Research Society-22 {[}SRS-22]) parameters of such group of patients were evaluated pre-and posttreatment. Results: A total 90 patients (females: 71, males: 29
Analysis of factors affecting baseline SF-36 Mental Component Summary in Adult Spinal Deformity and its impact on surgical outcomes
(TURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGY, 2018-01-01) Mmopelwa, Tiro; Ayhan, Selim; Yuksel, Selcen; Nabiyev, Vugar; Niyazi, Asli; Pellise, Ferran; Alanay, Ahmet; Perez Grueso, Francisco Javier Sanchez; Kleinstuck, Frank; Obeid, Ibrahim; Acaroglu, Emre; Grp, European Spine Study
Objectives: To identify the factors that affect SF-36 mental component summary (MCS) in patients with adult spinal deformity (ASD) at the time of presentation, and to analyse the effect of SF-36 MCS on clinical outcomes in surgically treated patients. Methods: Prospectively collected data from a multicentric ASD database was analysed for baseline parameters. Then, the same database for surgically treated patients with a minimum of 1-year follow-up was analysed to see the effect of baseline SF-36 MCS on treatment results. A clinically useful SF-36 MCS was determined by ROC Curve analysis. Results: A total of 229 patients with the baseline parameters were analysed. A strong correlation between SF-36 MCS and SRS-22, ODI, gender, and diagnosis were found (p < 0.05). For the second part of the study, a total of 186 surgically treated patients were analysed. Only for SF-36 PCS, the un-improved cohort based on minimum clinically important differences had significantly lower mean baseline SF-36 MCS (p < 0.001). SF-36 MCS was found to have an odds ratio of 0.914 in improving SF-36 PCS score (unit by unit) (p < 0.001). A cut-off point of 43.97 for SF-36 MCS was found to be predictive of SF-36 PCS (AUC = 0.631
Does the Application of Topical Intrawound Vancomycin Powder Affect Deep Surgical Site Infection and the Responsible Organisms after Spinal Surgery?: A Retrospective Case Series with a Historical Control Group
(KOREAN SOC SPINE SURGERY, 2020-01-01) Adhikari, Prashant; Nabiyev, Vugar Nabi; Bahadir, Sinan; Ayhan, Selim; Yuksel, Selcen; Palaoglu, Selcuk; Acaroglu, Emre
Study Design: Retrospective case series with a historical control group. Purpose: To compare the deep wound infection rates in patients undergoing spinal surgery with the application of topical intrawound vancomycin powder (TIVP) in the surgical site in addition to standard systemic prophylaxis with those in a matched historical cohort of patients for whom TIVP was not used. Overview of Literature: Surgical site infection (SSI) after spine surgery is debilitating and is responsible for a significant increase in the health care costs, hospital stay, and morbidities. Although the application of TIVP before surgical closure is a promising method for reducing the SSI rate after spine surgery, its use is controversial, and currently, research trials are focusing on identifying its safety, efficacy, and the potential patient population. Methods: A group of 88 patients who underwent posterior spinal surgery with TIVP administration (treatment group) was compared to a historical control group of 70 patients who had received only standard systemic intravenous prophylaxis (control group) for the analysis of deep SSI rate and the involved organisms. Results: The overall rate of deep SSIs was 2.5\% (4/158). All the SSIs were observed in patients who had posterior instrumentation and fusion for >= 3 levels. In the treatment group, the SSI rate was 3.4\% (3/88), and the bacteria isolated were Escherichia coli (n=2 ) and Pseudomonas aeruginosa (n=1). In the control group, the infection rate was 1.4\% (1/70), and the isolated bacteria were Morganella rnorganii and Staphylococcus epidermidis. No statistically significant association was found between the SSI rates of the treatment and control groups. Conclusions: Although the difference in the SSI rates was not statistically significant, the present results suggest that TIVP administration could not reduce the risk of deep SSIs after spinal surgery. Moreover, TIVP administration might also affect the underlying pathogens by increasing the propensity for gram-negative species.
Retrospective analysis of melanoma patients who had undergone PET-CT examination
(DERI ZUHREVI HASTALIKLAR DERNEGI, 2013-01-01) Bakar, Ozgur; Vardareli, Erkan; Sahin, Sedef; Yuksel, Selcen; Aksoy, Tamer
Background and Design: Pet positivity was found in 21 (37.5\%) the incidence of melanoma is increasing significantly in Turkey and in the whole world. Thus, Positron Emission Tomography-Computed Tomography (PET-CT), which is being reimbursed by the government for the documentation of metastases of clinically suspicious patients with stages 1 b and higher, is becoming widely used. This study aims to analyze, the histopathological features of the tumors and the clinical and demographic data on melanoma patients who had undergone PET-CT examination for the screening of metastases. Materials and Methods: We collected data on 57 melanoma patients who had undergone PET-CT evaluation in the Nuclear Medicine Department between 2004 and 2011. On the basis of PET-CT positivity, we retrospectively analyzed SUV (Standard uptake value), demographic data, Breslow thickness, primary tumor location, presence of histopathologically documented ulceration, perineural, vascular and lymphatic invasion, and metastases detected by other screening methods as well as the proposed treatment modalities. Results: PET-CT positivity was found in 22 (39\%) patients. The mean Breslow thickness was 5.12 +/- 6.29mm., 1 patient (\%7) with <= 1mm, 5 (36\%) with 2-4mm and 8 patients (57\%) with >4mm of Breslow thickness had distant metastases. Statistically significant correlation was found between Breslow thickness and positive PET-CT findings. The distribution of the primary tumor site was 35.3\%left-sided, 25.5\%right-sided and 39.2\%on the midline. All patients with scalp involvement had distant metastases. There was no statistically significant correlation of PET-CT positivity with histopathologically proven ulceration and perineural, vascular and lymphatic invasion. Thirty-one percent positive correlation was found between Breslow thickness and SUV. Forty-five percent of PET-CT positive patients had metastases documented with other screening methods as well. All but 2 patients with distant metastases had undergone wide tumor resection and adjuvant chemotherapy or radiotherapy. Conclusion: PET-CT complementing conventional imaging methods gains much importance in the treatment planning for some selected high-risk melanoma patients
The Effect of Discharging Patients with Low Hemoglobin Levels on Hospital Readmission and Quality of Life after Adult Spinal Deformity Surgery
(KOREAN SOC SPINE SURGERY, 2022-01-01) Nabi, Vugar; Ayhan, Selim; Yuksel, Selcen; Adhikari, Prashant; Vila-Casademunt, Alba; Pellise, Ferran; Perez-Grueso, Francisco Sanchez; Alanay, Ahmet; Obeid, Ibrahim; Kleinstueck, Frank; Acaroglu, Emre; Grp, European Spine Study
Study design: Retrospective cohort. Purpose: This study aims to evaluate the impact of anemia on functional outcomes, health-related quality of life (HRQoL), and early hospital readmission (EHR) rates after adult spinal deformity (ASD) surgery at the time of discharge from the hospital. Overview of literature: Concerns with risks of transfusion, insufficient evidence for its benefits, and the possibility of associated adverse outcomes have led to restrictive transfusion practices. Therefore, patients are discharged according to patient blood management programs that are implemented in hospitals nationwide to reduce unnecessary blood transfusions. However, not many comprehensive kinds of studies exist on the effect of postoperative anemia on functional life and complications. Methods: Anemia severity was defined following the 2011 World Health Organization guidelines. All patients had HRQoL tests as well as complete blood counts pre- and postoperatively. EHR is the admission within 30 days of discharge and was used as the dependent parameter. Results: This study comprised 225 surgically treated ASD patients with a median age of 62.0 years, predominantly women (80\%). Of the 225 patients, 82, 137, and six had mild, moderate, and severe anemia at the time of discharge, respectively. Seventeen of the patients (mild {[}11, 64.7\%]
The Global Spine Care Initiative: methodology, contributors, and disclosures
(SPRINGER, 2018-01-01) Johnson, Claire D.; Haldeman, Scott; Nordin, Margareta; Chou, Roger; Cote, Pierre; Hurwitz, Eric L.; Green, Bart N.; Kopansky-Giles, Deborah; Randhawa, Kristi; Cedraschi, Christine; Ameis, Arthur; Acaroglu, Emre; Aartun, Ellen; Adjei-Kwayisi, Afua; Ayhan, Selim; Aziz, Amer; Bas, Teresa; Blyth, Fiona; Borenstein, David; Brady, O'Dane; Brooks, Peter; Camilleri, Connie; Castellote, Juan M.; Clay, Michael B.; Davatchi, Fereydoun; Dudler, Jean; Dunn, Robert; Eberspaecher, Stefan; Emmerich, Juan; Farcy, Jean Pierre; Fisher-Jeffes, Norman; Goertz, Christine; Grevitt, Michael; Griffith, Erin A.; Hajjaj-Hassouni, Najia; Hartvigsen, Jan; Hondras, Maria; Kane, Edward J.; Laplante, Julie; Lemeunier, Nadege; Mayer, John; Mior, Silvano; Mmopelwa, Tiro; Modic, Michael; Moss, Jean; Mullerpatan, Rajani; Muteti, Elijah; Mwaniki, Lillian; Ngandeu-Singwe, Madeleine; Outerbridge, Geoff; Rajasekaran, Shanmuganathan; Shearer, Heather; Smuck, Matthew; Sonmez, Erkin; Tavares, Patricia; Taylor-Vaisey, Anne; Torres, Carlos; Torres, Paola; van der Horst, Alexander; Verville, Leslie; Vialle, Emiliano; Kumar, Gomatam Vijay; Vlok, Adriaan; Watters III, William; Wong, Chung Chek; Wong, Jessica J.; Yu, Hainan; Yuksel, Selcen
Purpose The purpose of this report is to describe the Global Spine Care Initiative (GSCI) contributors, disclosures, and methods for reporting transparency on the development of the recommendations. Methods World Spine Care convened the GSCI to develop an evidence-based, practical, and sustainable healthcare model for spinal care. The initiative aims to improve the management, prevention, and public health for spine-related disorders worldwide
The Global Spine Care Initiative: model of care and implementation
(SPRINGER, 2018-01-01) Johnson, Claire D.; Haldeman, Scott; Chou, Roger; Nordin, Margareta; Green, Bart N.; Cote, Pierre; Hurwitz, Eric L.; Kopansky-Giles, Deborah; Acaroglu, Emre; Cedraschi, Christine; Ameis, Arthur; Randhawa, Kristi; Aartun, Ellen; Adjei-Kwayisi, Afua; Ayhan, Selim; Aziz, Amer; Bas, Teresa; Blyth, Fiona; Borenstein, David; Brady, O'Dane; Brooks, Peter; Camilleri, Connie; Castellote, Juan M.; Clay, Michael B.; Davatchi, Fereydoun; Dudler, Jean; Dunn, Robert; Eberspaecher, Stefan; Emmerich, Juan; Farcy, Jean Pierre; Fisher-Jeffes, Norman; Goertz, Christine; Grevitt, Michael; Griffith, Erin A.; Hajjaj-Hassouni, Najia; Hartvigsen, Jan; Hondras, Maria; Kane, Edward J.; Laplante, Julie; Lemeunier, Nadege; Mayer, John; Mior, Silvano; Mmopelwa, Tiro; Modic, Michael; Moss, Jean; Mullerpatan, Rajani; Muteti, Elijah; Mwaniki, Lillian; Ngandeu-Singwe, Madeleine; Outerbridge, Geoff; Rajasekaran, Shanmuganathan; Shearer, Heather; Smuck, Matthew; Sonmez, Erkin; Tavares, Patricia; Taylor-Vaisey, Anne; Torres, Carlos; Torres, Paola; van der Horst, Alexander; Verville, Leslie; Vialle, Emiliano; Kumar, Gomatam Vijay; Vlok, Adriaan; Watters III, William; Wong, Chung Chek; Wong, Jessica J.; Yu, Hainan; Yuksel, Selcen
Purpose Spine-related disorders are a leading cause of global disability and are a burden on society and to public health. Currently, there is no comprehensive, evidence-based model of care for spine-related disorders, which includes back and neck pain, deformity, spine injury, neurological conditions, spinal diseases, and pathology, that could be applied in global health care settings. The purposes of this paper are to propose: (1) principles to transform the delivery of spine care
The Influence of Diagnosis, Age, and Gender on Surgical Outcomes in Patients With Adult Spinal Deformity
(SAGE PUBLICATIONS LTD, 2018-01-01) Ayhan, Selim; Yuksel, Selcen; Nabiyev, Vugar; Adhikari, Prashant; Villa-Casademunt, Alba; Pellise, Ferran; Sanchez Perez-Grueso, Francisco; Alanay, Ahmet; Obeid, Ibrahim; Kleinstueck, Frank; Acaroglu, Emre; Grp, European Spine Study
Study Design: Retrospective review of prospectively collected data from a multicentric database. Objectives: To determine the clinical impact of diagnosis, age, and gender on treatment outcomes in surgically treated adult spinal deformity (ASD) patients. Methods: A total of 199 surgical patients with a minimum follow-up of 1 year were included and analyzed for baseline characteristics. Patients were separated into 2 groups based on improvement in health-related quality of life (HRQOL) parameters by minimum clinically important difference. Statistics were used to analyze the effect of diagnosis, age, and gender on outcome measurements followed by a multivariate binary logistic regression model for these results with statistical significance. Results: Age was found to affect SF-36 PCS (Short From-36 Physical Component Summary) score significantly, with an odds ratio of 1.017 (unit by unit) of improving SF-36 PCS score on multivariate analysis (P < .05). The breaking point in age for this effect was 37.5 years (AUC = 58.0, P = .05). A diagnosis of idiopathic deformity would increase the probability of improvement in Oswestry Disability Index (ODI) by a factor of 0.219 and in SF-36 PCS by 0.581 times (P < .05). Gender was found not to have a significant effect on any of the HRQOL scores. Conclusions: Age, along with a diagnosis of degenerative deformity, may have positive effects on the likelihood of improvement in SF-36 PCS (for age) and ODI (for diagnosis) in surgically treated patients with ASD and the breaking point of this effect may be earlier than generally anticipated. Gender does not seem to affect results. These may be important in patient counseling for the anticipated outcomes of surgery.