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Item Gastrostomy in Hospitalized Patients with Acute Stroke: ``NoroTek'' Turkey Point Prevalence Study Subgroup Analysis(GALENOS PUBL HOUSE, 2022-01-01) Topcuoglu, Mehmet Akif; Ozdemir, Atilla Ozcan; Aykac, Ozlem; Milanoglu, Aysel; Gokce, Mustafa; Bavli, Songul; Cabalar, Murat; Yayla, Vildan; Erdogan, Haci Ali; Ozkul, Ayca; Gunes, Aygul; Degirmenci, Bahar; Aluclu, Ufuk; Kozak, Hasan Huseyin; Gungor, Levent; Erdogan, Mucahid; Acar, Zeynep Ozdemir; Cenikli, Utku; Kablan, Yuksel; Yilmaz, Arda; Genc, Hamit; Nazliel, Bijen; Caglayan, Hale Batur; Gencer, Elif Sarionder; Ay, Halil; Demirbas, Hayri; Akdogan, Ozlem; Emre, Ufuk; Yildiz, Ozlem Kayim; Bolayir, Asli; Demir, Turgay; Tanriverdi, Zeynep; Tekan, Ulgen Yalaz; Akpinar, Cetin Kursad; Ozkan, Esra; Ilik, Faik; Sirin, Hadiye; Guler, Ayse; Onder, Halil; Bektas, Hesna; Ocek, Levent; Bakar, Mustafa; Ongun, Nedim; Krespi, Yakup; Isikay, Canan Togay; Aslanbaba, Eda; Sorgun, Mine; Gurkas, Erdem; Karadeli, Hasan Huseyin; Midi, Ipek; Ilgezdi, Irem; Bilgic, Adnan Burak; Akyol, Sener; Epceliden, M. Tuncay; Atmaca, Murat Mert; Kursun, Oguzhan; Keskin, Onur; Sirinocak, Pinar Bekdik; Baydemir, Recep; Akcakoyunlu, Merve; Ozturk, Serefnur; Ozel, Tugba; Unal, Ali; Dora, Babur; Yurekli, Vedat Ali; Arlier, Zulfikar; Eren, Alper; Yilmaz, Ayse; Kisabay, Aysin; Acar, Bilgehan; Bastan, Birgul; Acar, Zeynep; Niflioglu, Buket; Guven, Bulent; Kaya, Dilaver; Afsar, Nazire; Yazici, Duran; Aytac, Emrah; Yaka, Erdem; Toplutas, Eren; Degirmenci, Eylem; Ince, Fatma Birsen; Buyukserbetci, Gulseren; Aydin, Isa; Cetiner, Mustafa; Sen, Mustafa; Turgut, Nilda; Kale, Nilufer; Coban, Eda; Yesilot, Nilufer; Ekizoglu, Esme; Kizek, Ozgu; Birgili, Ozlem; Yevgi, Recep; Kunt, Refik; Giray, Semih; Akkas, Sinem Yazici; Senadim, Songul; Yoldas, Tahir; Asil, Talip; Duman, Taskin; Atasoy, Tugrul; Cinar, Bilge Piri; Demir, Tulin; Can, Ufuk; Unsal, Yaprak Ozum; Eskut, Neslihan; Aslan, Yildiz; Bas, Demet Funda; Sener, Ufuk; Yilmaz, Zahide; Bozdogan, Zehra; Alioglu, Zekeriya; Arsava, Ethem MuratObjective: Nutritional status assessment, dysphagia evaluation and enteral feeding decision are important determinants of prognosis in acute neurovascular diseases. Materials and Methods: NoroTek is a point prevalence study conducted with the participation of 87 hospitals spread across all health sub regions of Turkey conducted on 10-May-2018 (World Stroke Awareness Day). A total of 972 hospitalized neurovascular patients {[}female: 53\%, age: 69 +/- 14Item Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study(KARE PUBL, 2021-01-01) Duman, Taskin; Cinar, Nilgun; Uluduz, Derya; Domac, Fusun Mayda; Ozturk, Serefnur; Yayla, Vildan; Karahan, Ali Yavuz; Afsar, Nazire; Sungur, Mehmet Ali; Goksu, Eylem Ozaydin; Yurekli, Vedat Ali; Genc, Hamit; Utku, Uygar; Sahin, Sevki; Tekeli, Hakan; Tokuc, Firdevs Ezgi; Uzuner, Nevzat; Senol, Mehmet Guney; Yilmaz, Arda; Gokce, Mustafa; Demirci, Seden; Kusbeci, Ozge Yilmaz; Uzuner, Gulnur Tekgol; Caglayan, Hale Zeynep Batur; Acikgoz, Mustafa; Kurucu, Hatice; Ozdag, Mehmet Fatih; Baybas, Sevim; Ekmekci, Hakan; Cabalar, Murat; Yaman, Mehmet; Bektas, Hesna; Kaplan, Yuksel; Goksel, Basak Karakurum; Milanlioglu, Aysel; Orken, Dilek Necioglu; Aluclu, Mehmet Ufuk; Colakoglu, Sena; Tufekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Tascilar, Nida; Goksan, Baki; Kozak, Hasan Huseyin; Misirli, Cemile Handan; Kucukoglu, Hayriye; Midi, Ipek; Mengulluoglu, Necdet; Aytac, Emrah; Yesilot, Nilufer; Ince, Birsen; Yalin, Osman Ozgur; Gunes, Taskin; Oruc, Serdar; Demir, SerkanObjectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache {[}NIH]). Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared. Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29\% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group. Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.Item Epileptic seizures in cerebral venous sinus thrombosis: Subgroup analysis of VENOST study(W B SAUNDERS CO LTD, 2020-01-01) Uluduz, Derya; Midi, Ipek; Duman, Taskin; Yayla, Vildan; Karahan, Ali Yavuz; Afsar, Nazire; Goksu, Eylem Ozaydin; Mengulluoglu, Necdet; Aytac, Emrah; Sungur, Mehmet Ali; Yesilot, Nilufer; Ince, Birsen; Yalin, Osman Ozgur; Oruc, Serdar; Senol, Mehmet Guney; Yilmaz, Arda; Gokce, Mustafa; Demirci, Seden; Kusbeci, Ozge Yilmaz; Uzuner, Gulnur; Caglayan, Hale Zeynep Batur; Acikgoz, Mustafa; Kurucu, Hatice; Ozdag, Fatih; Baybas, Sevim; Ekmekci, Hakan; Cabala, Murat; Yaman, Mehmet; Yurekli, Vedat Ali; Tekeli, Hakan; Genc, Hamit; Utku, Uygar; Sahin, Sevki; Tokuc, Firdevs Ezgi Ucan; Uzuner, Nevzat; Bektas, Hesna; Kablan, Yuksel; Goksel, Basak Karakurum; Milanlioglu, Aysel; Orken, Dilek Necioglu; Aluclu, Ufuk; Colakoglu, Sena; Tufekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Tascilar, Nida; Goksan, Baki; Kozak, Hasan Huseyin; Demir, Serkan; Misirli, Cemile Handan; Kucukoglu, Hayriye; Cinar, Nilgun; Domac, Fusun Mayda; Ozturk, Serefnur; Gunes, TaskinPurpose: The aim of this study is to evaluate the presence and prognostic impact of early seizures in cerebral venous sinus thrombosis patients (CVST). Method: VENOST is a retrospective and prospective national multicenter observational study. CVST patients with or without epileptic seizures (ES) were analyzed and compared in terms of demographic and imaging data, causative factors, clinical variables, and prognosis in a total of 1126 patients. Results: The mean age of the patients in the ES group was 39.73 +/- 12.64 and 40.17 +/- 14.02 years in the non-ES group (p > 0.05). Epileptic seizures were more common (76.6 \%) in females (p < 0.001). Early ES occurred in 269 of 1126 patients (23.9 \%). Epileptic seizures mainly presented in the acute phase (71.4 \%) of the disease (p < 0.001). Majority of these (60.5 \%) were in the first 24 h of the CVST. The most common neurological signs were focal neurologic deficits (29.9 \%) and altered consciousness (31.4 \%) in the ES group. Superior sagittal sinus (SSS) and cortical veins (CV) involvement were the most common sites of thrombosis and the mostly related etiology were found puerperium in seizure group (30.3 \% vs 13.9 \%). Patients with seizures had worse outcome in the first month of the disease (p < 0.001) but these did not have any influence thereafter. Conclusions: In this largest CVST cohort (VENOST) reported female sex, presence of focal neurological deficits and altered consciousness, thrombosis of the SSS and CVs, hemorrhagic infarction were risk factors for ES occurrence in patients with CVST.Item Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study(HINDAWI LTD, 2020-01-01) Uluduz, Derya; Sahin, Sevki; Duman, Taskin; Ozturk, Serefnur; Yayla, Vildan; Afsar, Nazire; Uzuner, Nevzat; Midi, Ipek; Cinar, Nilgun; Sungur, Mehmet Ali; Domac, Fusun Mayda; Ince, Birsen; Goksan, Baki; Misirli, Cemile Handan; Bakar, Mustafa; Kozak, Hasan Huseyin; Colakoglu, Sena; Karahan, Ali Yavuz; Goksu, Eylem Ozaydin; Ozdag, Fatih; Senol, Mehmet Guney; Yurekli, Vedat Ali; Aluclu, Ufuk; Demir, Serkan; Kucukoglu, Hayriye; Oruc, Serdar; Yesilot, Nilufer; Kusbeci, Ozge Yimaz; Nazliel, Bijen; Tokuc, Firdevs Ezgi Ucan; Bektas, Hesna; Tascilar, Fatma Nida; Aytac, Emrah; Gokce, Mustafa; Caglayan, Hale Zeynep Batur; Tufekci, Ahmet; Uzuner, Gulnur; Orken, Dilek Necioglu; Yalin, Osman Ozgur; Utku, Uygar; Yilmaz, Arda; Genc, Hamit; Cabalar, Murat; Milanlioglu, Aysel; Ekmekci, Hakan; Zeydan, Burcu; Baybas, Sevim; Kablan, Yuksel; Goksel, Basak Karakurum; Acikgoz, Mustafa; Kurucu, Hatice; Demirci, Seden; Gunes, TaskinBackground. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelaeItem The COVID-19 from Neurological Overview(GALENOS PUBL HOUSE, 2020-01-01) Acar, Turkan; Demirel, Esra Aciman; Afsar, Nazire; Akcali, Aylin; Demir, Gulsen Akman; Alagoz, Aybala Neslihan; Mengi, Tugce Angin; Arsava, Ethem Murat; Ayta, Semih; Bebek, Nerses; Bilgic, Basar; Boz, Cavit; Cakar, Arman; Celebisoy, Nese; Cevik, Mehmet Ugur; Delen, Firuze; Tekce, Hacer Durmus; Ekmekci, Hakan; Elmali, Ayse Deniz; Erdinc, Oguz Osman; Erdogan, Fusun Ferda; Eren, Fettah; Ergun, Ufuk; Parman, Yesim Gulsen; Gumus, Haluk; Algin, Demet Ilhan; Karabudak, Rana; Karadas, Omer; Yildiz, Ozlem Kayim; Koc, Emine Rabia; Adapinar, Demet Ozbabalik; Ozdemir, Atilla Ozcan; Ozturk, Serefnur; Kocaman, Ayse Sagduyu; Sahin, Sevki; Topcuoglu, Esen Saka; Sener, Ozden; Tezer, F. Irsel; Togrol, Rifat Erdem; Tokcaer, Ayse Bora; Topcuoglu, Mehmet Akif; Tuncer, Nese; Uca, Ali Ulvi; Uluc, Kayihan; Yaka, Erdem; Yon, Mehmet IlkerItem Brain MRI Findings in Patients in the Intensive Care Unit with COVID-19 Infection(RADIOLOGICAL SOC NORTH AMERICA, 2020-01-01) Kandemirli, Sedat G.; Dogan, Lerzan; Sarikaya, Zeynep T.; Kara, Simay; Akinci, Canan; Kaya, Dilaver; Kaya, Yildiz; Yildirim, Duzgun; Tuzuner, Filiz; Yildirim, Mustafa S.; Ozluk, Enes; Gucyetmez, Bulent; Karaarslan, Ercan; Koyluoglu, Isil; Kaya, Hande S. Demirel; Mammadov, Orkhan; Ozdemir, Ilkay Kisa; Afsar, Nazire; Yalcinkaya, Beyza Citci; Rasimoglu, Sevdinaz; Guduk, Duygu E.; Jima, Ararso Kedir; Ilksoz, Aylin; Ersoz, Vildan; Eren, Meltem Yonca; Celtik, Nilufer; Arslan, Serdar; Korkmazer, Bora; Dincer, Saban S.; Gulek, Elif; Dikmen, Ibrahim; Yazici, Murathan; Unsal, Serkan; Ljama, Taner; Demirel, Ismail; Ayyildiz, Aykut; Kesimci, Isil; Deveci, Sahika Bolsoy; Tutuncu, Melih; Kizilkilic, Osman; Telci, Lutfi; Zengin, Rehile; Dincer, Alp; Akinci, Ibrahim O.; Kocer, NaciItem Comparison of conventional and modern methods in determining ischemic stroke etiology by general and stroke neurologists(TUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY, 2019-01-01) Kunt, Refik; Kutluk, Mustafa Kursad; Tiftikcioglu, Bedile Irem; Afsar, Nazire; Erdemoglu, Ali Kemal; Gedizlioglu, Muhtesem; Ozturk, VesileBackground/aim: This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems. Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS. Each neurologist was assessed for consistency and compliance in pairs. Concordance among all four neurologists was investigated and evaluated using the kappa (kappa) value. Results: The kappa (kappa) value of diagnostic compliance between stroke neurologists was 0.61 (95\% CI: 0.45-0.77) for TOAST and 0.78 (95\% CI: 0.62-0.94) for CSS-5. The kappa (kappa) value was 0.64 (95\% CI: 0.48-0.80) for TOAST and 0.75 (95\% CI: 0.60-0.91) for CCS-5 for general neurologists. Compliance was moderate {[}kappa: 0.59 (95\% CI: 0.52-0.65)] for TOAST and was strong {[}kappa: 0.75 (95\% CI: 0.68-0.81)] for CCS-5 for all 4 neurologists. `Cardioembolism' (91.04\%) had the highest compliance in both systems. The frequency of the group with `undetermined etiologies' was less in the CCS (26\%) compared to TOAST. Conclusion: The CCS system improved compliance in both stroke and general neurologists compared with TOAST. This suggests that the automatic, evidence-based, easily reproducible CCS system was superior to the TOAST system.Item Human Metapneumovirus Infection in Adults as the Differential Diagnosis of COVID-19(GALENOS YAYINCILIK, 2021-01-01) Dogan, Lerzan; Akinci, Canan; Sarikaya, Zeynep Tugce; Kaya, Hande Simten Demirel; Zengin, Rehile; Mammadov, Orkhan; Ilksoz, Aylin; Ozdemir, Ilkay Kisa; Eren, Meltem Yonca; Afsar, Nazire; Kocagoz, Sesin; Akinci, Ibrahim OzkanHuman metapneumovirus (HMPV) is a respiratory tract virus identified 18 years prior to severe acute respiratory syndrome coronavirus-2. Both viruses cause acute respiratory failure characterised by a rapid onset of widespread inflammation in the lungs with clinical symptoms similar to those reported for other viral respiratory lung infections. HMPV, more generally known as childhood viral infection, causes mild and self-limiting infections in the majority of adults, but clinical courses can be complicated in risky groups and associated morbidity and mortality are considerable. Moreover, adults are not regularly screened for HMPV and the prevalence of adult HMPV infections in Turkey is unknown, with previous reports in the paediatric population. This should always be kept in mind during the coronavirus disease-2019 pandemic, particularly when neurological complications are added to respiratory findings. In our study, two adult cases of HMPV pneumonia and encephalitis have been recorded.Item A Case With New-Onset Neuromyelitis Optica Spectrum Disorder Following COVID-19 mRNA BNT162b2 Vaccination(LIPPINCOTT WILLIAMS \& WILKINS, 2022-01-01) Caliskan, Ilay; Bulus, Eser; Afsar, Nazire; Altintas, AyseIntroduction: In the midst of the coronavirus disease of 2019 pandemic, active immunization by effective vaccination gained utmost importance in terms of global health. The messenger RNA (mRNA) vaccines are novel strategies requiring clinical surveillance for adverse events. Case Report: We report a 43-year-old previously healthy female with an optic neuritis attack 24 hours following immunization with the second dose of coronavirus disease of 2019 mRNA BNT162b2 vaccine. A second transverse myelitis attack together with an elevated anti-AQP-4 antibody titer confirmed the diagnosis of neuromyelitis optica spectrum disorder. Conclusion: Our case identifies the BNT162b2 vaccine as a possible trigger for neuromyelitis optica spectrum disorder. This rare and potentially coincidental event has no implications for vaccine administration practices. However, further research is needed to elucidate the effects of mRNA vaccines on humoral and cell-mediated immunity.Item Plasmapheresis treatment in COVID-19-related autoimmune meningoencephalitis: Case series(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2020-01-01) Dogan, Lerzan; Kaya, Dilaver; Sarikaya, Tugce; Zengin, Rehile; Dincer, Alp; Akinci, Ibrahim Ozkan; Afsar, NazireSevere SARS-CoV-2 (COVID-19) infection has the potential for a high mortality rate. In this paper, we report the results of plasmapheresis treatment in a series of severely ill patients with COVID-19-related autoimmune meningoencephalitis in the Intensive Care Unit (ICU).