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Permanent URI for this collectionhttps://hdl.handle.net/11443/932
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Item p-Coumaric acid has an ameliorative effect on peptic ulcer: a macroscopic, microscopic and biochemical analysis(MARMARA UNIV, FAC MEDICINE, 2021-01-01) Kolgazi, Meltem; Oztosun, Gulsen; Yalcin, Muge; Unan, Zehra Neslisah; Arsoy, Edanur; Oral, Simge; Cilingir, Sumeyye; Acikel Elmas, Merve; Arbak, SerapObjective: p-Coumaric acid is commonly found in edible plants in nature and is known to be an effective antioxidant. This study aimed to investigate the therapeutic effects of p-coumaric acid on ethanol-induced gastric ulcer model Materials and Methods: After an 18-hour starvation period, the ulcer was induced in male Sprague-Dawley (250-300) rats by intragastric administration of 75\% ethanol. An hour after ulcer induction, p-coumaric acid (250 mg/kg) suspended in 1 ml tween-80 was administered intragastrically. The control and ulcer groups received 1 ml tween-80, One hour later, all rats were euthanized and stomach samples were collected for macroscopic examination, histological evaluation, and measurement of myeloperoxidase (MPO) activity, malondialdehyde (MDA), and glutathione (GSH) levels. Results: Ethanol induction resulted in gastric epithelial and mucosa' injury, increased MPO activity and MDA levels