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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Arpaci, Rabia BozdoganHas files: Yes

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    Primary pericardial extragastrointestinal stromal tumor: A case report and literature review
    (SPANDIDOS PUBL LTD, 2015-01-01) Arpaci, Taner; Tokat, Fatma; Arpaci, Rabia Bozdogan; Akbas, Tugana; Ugurluer, Gamze; Yavuz, Sinan
    Gastrointestinal stromal tumors (GISTs) are the most prevalent mesenchymal tumors of the gastrointestinal tract. GISTs are considered to originate from the interstitial cells of Cajal, the pacemakers of the peristaltic activity of the gastrointestinal tract. More than 95\% of GISTs express KIT protein and discovered on GIST-1. GISTs may also be encountered in locations outside the gastrointestinal tract, in which case they are referred to as extra-GISTs (EGISTs) and often behave more aggressively. This is the case report of a primary pericardial EGIST in a 53-year-old male patient, confirmed by immunohistochemistry. To the best of our knowledge, this is the third case of EGIST diagnosed above the diaphragm, without being associated with the esophageal wall. Two cases of primary EGIST arising from the pleura were reported previously. In addition, this is the first reported case of an EGIST originating from the pericardium.
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    Desmoplastic neurotropic melanoma: A diagnostic trap
    (DERI ZUHREVI HASTALIKLAR DERNEGI, 2015-01-01) Arpaci, Rabia Bozdogan; Kara, Tuba; Serinsoz, Ebru; Karabulut, Yasemin Yuyucu; Gursoy, Didar; Sari, Alper; Ozgur, Anil; Arpaci, Taner
    Desmoplastic neurotropic melanoma (DNM) is known as a rare variant of cutaneous melanoma. The authors defined the term `neurotropic' which is used to refer to the associated nerve infiltration or neural differentiation. A 74-year-old female applied to the plastic surgery clinic with a one-year history of a nodule in the left infraorbital skin. The lesion was excised by the surgeons and was sent to the pathology department. The tumor with spindle cells in a scar-like stroma was detected microscopically and diagnosed as a `dermatofibroma'. Eight months after surgery, a deep-seated nodule recurred at the same place. This nodule was re-excised. In this sample, we observed hypercellularity, atypical mitoses and nerve infiltration of the spindle tumor cells having strong positive staining with S-100 protein and negative staining with HMB-45, thus, the ultimate diagnosis was DNM. The differential diagnosis of this lesion includes many benign and malignant entities. This is crucial because of the potential for recurrence and metastasis of the lesion.