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Item Is the new ASNM intraoperative neuromonitoring supervision ``guideline'' a trustworthy guideline? A commentary (vol 33, pg 185, 2019)(SPRINGER HEIDELBERG, 2019-01-01) Skinner, Stanley A.; Aydinlar, Elif Ilgaz; Borges, Lawrence F.; Carter, Bob S.; Currier, Bradford L.; Deletis, Vedran; Dong, Charles; Dormans, John Paul; Drost, Gea; Fernandez-Conejero, Isabel; Hoffman, E. Matthew; Holdefer, Robert N.; Teixeira Kimaid, Paulo Andre; Koht, Antoun; Kothbauer, Karl F.; MacDonald, David B.; McAuliffe III, John J.; Morledge, David E.; Morris, Susan H.; Norton, Jonathan; Novak, Klaus; Park, Kyung Seok; Perra, Joseph H.; Prell, Julian; Rippe, David M.; Sala, Francesco; Schwartz, Daniel M.; Segura, Martin J.; Seidel, Kathleen; Seubert, Christoph; Simon, Mirela V.; Soto, Francisco; Strommen, Jeffrey A.; Szelenyi, Andrea; Tello, Armando; Ulkatan, Sedat; Urriza, Javier; Wilkinson, MarshallItem Is the new ASNM intraoperative neuromonitoring supervision ``guideline'' a trustworthy guideline? A commentary(SPRINGER HEIDELBERG, 2019-01-01) Skinner, Stanley A.; Aydinlar, Elif Ilgaz; Borges, Lawrence F.; Carter, Bob S.; Currier, Bradford L.; Deletis, Vedran; Dong, Charles; Dormans, John Paul; Drost, Gea; Fernandez-Conejero, Isabel; Hoffman, E. Matthew; Holdefer, Robert N.; Teixeira Kimaid, Paulo Andre; Koht, Antoun; Kothbauer, Karl F.; MacDonald, David B.; McAuliffe III, John J.; Morledge, David E.; Morris, Susan H.; Norton, Jonathan; Novak, Klaus; Park, Kyung Seok; Perra, Joseph H.; Prell, Julian; Rippe, David M.; Sala, Francesco; Schwartz, Daniel M.; Segura, Martin J.; Seidel, Kathleen; Seubert, Christoph; Simon, Mirela V.; Soto, Francisco; Strommen, Jeffrey A.; Szelenyi, Andrea; Tello, Armando; Ulkatan, Sedat; Urriza, Javier; Wilkinson, MarshallItem Cluster Analysis Revealed Two Hidden Phenotypes of Cluster Headache(FRONTIERS MEDIA SA, 2022-01-01) Dikmen, Pinar Yalinay; Ari, Cagla; Sahin, Erdi; Ertas, Mustafa; Domac, Fusun Mayda; Aydinlar, Elif Ilgaz; Sahin, Aysenur; Ozge, Aynur; Ozguner, Hilal; Karadas, Omer; Shafiyev, Javid; Vuralli, Doga; Aktan, Cile; Oguz-Akarsu, Emel; Karli, Necdet; Zarifoglu, Mehmet; Bolay, Hayrunisa; Ekizoglu, Esme; Orhan, Elif Kocasoy; Tasdelen, Bahar; Baykan, BetulObjectiveTo investigate the possible subgroups of patients with Cluster Headache (CH) by using K-means cluster analysis. MethodsA total of 209 individuals (mean (SD) age: 39.8 (11.3) years), diagnosed with CH by headache experts, participated in this cross-sectional multi-center study. All patients completed a semi-structured survey either face to face, preferably, or through phone interviews with a physician. The survey was composed of questions that addressed sociodemographic characteristics as well as detailed clinical features and treatment experiences. ResultsCluster analysis revealed two subgroups. Cluster one patients (n = 81) had younger age at diagnosis (31.04 (9.68) vs. 35.05 (11.02) yearsItem The effect of femoral nerve block on fracture healing via expressions of growth factors and beta-catenin(VIA MEDICA, 2016-01-01) Uslu, Serap; Irban, Arzu Gercek; Gereli, Arel; Aydinlar, Elif Ilgaz; Elpen, Pinar; Ince, UmitIntroduction. Many patients of all ages are admitted to hospital due to bone fractures. The etiology of fracture has a very wide spectrum, ranging from motor accidents to pathological conditions such as tumors, osteoporosis, and others. Bone fracture healing is a well-programmed and well-organized process, but is also long and intractable. The outcome of this process is therefore affected by many factors, such as the patient's age, ethnicity, nutritional status, and extent of the fracture. At present, regional analgesic techniques are frequently applied in order to avoid the complications of systemic opioid administration, central block applications. Femoral block is one of the regional analgesic techniques frequently applied by anesthesiologists when the lower extremities are involved. In this study, we evaluated the effect of femoral nerve block on the healing of an experimental non-stabilized femur fracture via expression of TGF-beta, VEGF, and beta-catenin and bone histomorphometry in rats. Material and methods. In the control group, only the femoral fracture was performed and the bone was not fixated, similarly as in other groups. In the One-Day Block group, a one-time femoral nerve block was applied after the femoral fracture. In the Three-Day Block group, a daily femoral nerve block was performed for three days after the femoral fracture. On Days 4, 7, and 13, femurs were excised. The bone sections were stained with hematoxylin-eosin to evaluate bone tissue and Safranin O to assess callus tissue, cartilaginous tissue, and new bone areas. TGF-beta, VEGF, and beta-catenin were assessed by immunohistochemistry. Results. Histomorphometric analysis revealed that femoral block application had a positive impact on bone healing. TGF-beta expression in the One-Day and Three-Day Block Groups was significantly higher than in the control group at all times, as was also the case with VEGF expression. On day 13, beta-catenin expression was significantly higher in the Three-Day Block group than the others. Conclusions. The results of the study suggests that the applications of a femoral nerve block for perioperative analgesia, for either one day or three days, resulted in better and more rapid bone healing.Item Intraoperative Neurophysiological Monitoring to Prevent New Neurological Deficits in Spinal Tumor Cases(TURKISH NEUROLOGICAL SOC, 2014-01-01) Aydinlar, Elif Ilgaz; Dikmen, Pinar Yalinay; Silav, Gokalp; Berkman, Mehmet Zafer; Elmaci, Ilhan; Ozgen, SerdarObjective: Intraoperative neurophysiological monitoring was carried out in patients with spinal cord tumors. These patients were retrospectively evaluated for new postoperative neurological deficits. Materials and Methods: A total of 32 spinal tumor cases (8 cervical, 14 thoracic, 10 lumbosacral), 17 male and 15 female, patients between 2-66 years of age (mean 44.1 +/- 20) operated in our center were evaluated. All of our cases were monitored with somatosensory evoked potentials (SEP) muscular motor evoked potentials (MEP) and free run electromyography. Spinal MEP (D wave), bulbocavernosus reflex (BCR) and pudendal SEP were obtained in appropriate cases. Results: Five cases presented with temporary new postoperative neurological deficits in the form of strength loss. Neurophysiological recordings of all of these patients showed either temporary or permanent deterioration during surgery. The tumor was removed completely or almost completely in 26, near-completely in 4 and partially in 2 cases and none of our cases had a new permanent deficit. Conclusion: The functional integrity of the lateral and dorsal columns of the spine can be assessed by SEP and muscular MEP recording. Additional information about the neurological tissue is given by spinal MEP, BCR and pudendal SEP in suitable cases. We did not experience any false positive or negative results in our cases and we believe that the combined use of intraoperative spinal and MEP in spinal column located tumors gives reliable information about postoperative neurological outcome.Item The relation of sexual function to migraine-related disability, depression and anxiety in patients with migraine(BMC, 2014-01-01) Eraslan, Defne; Dikmen, Pinar Yalinay; Aydinlar, Elif Ilgaz; Incesu, CemDepression and anxiety are two phenomena that affect quality of life as well as sexual function. Depression and anxiety levels are reported to be high in migraine sufferers. We aimed to understand whether sexual function in women with migraine was associated to migraine-related disability and frequency of migraine attacks, and whether this relationship was modulated by depressive and anxiety symptoms. As migraine is more commonly seen in females, a total of 50 women with migraine were included. The diagnosis of migraine with or without aura was confirmed by two specialists in Neurology, according to the second edition of International Headache Society (IHS) International Classification of Headache Disorders (ICHD-II) in 2004. Migraine disability assessment scale score, female sexual function index scores, Beck depression inventory score and Beck anxiety inventory scores. Mean MIDAS score was 19.3 +/- 12.8, and mean number of migraine attacks per month were 4.3 +/- 2.7. Mean Female Sexual Function Index score was 20.9 +/- 5.9 and 90\% of patients had sexual dysfunction. Sexual dysfunction was not related to MIDAS score or frequency and severity of attacks. No relationship between sexual function and anxiety was found, whereas severity of depressive symptoms was closely related to sexual function. Depressive symptoms affected all dimensions of sexual function, except for pain. Sexual dysfunction seemed to be very common in our patients with migraine, while not related to migraine related disability, frequency of attacks and migraine severity or anxiety. The most important factor that predicted sexual function was depression, which was also independent of disease severity and migraine related disability. While future larger scale studies are needed to clarify the exact relationship, depressive and sexual problems should be properly addressed in all patients with migraine, regardless of disease severity or disability.Item Association between somatic amplification, anxiety, depression, stress and migraine(BMC, 2013-01-01) Yavuz, Burcu Goksan; Aydinlar, Elif Ilgaz; Dikmen, Pinar Yalinay; Incesu, CemThe aim of this study is to investigate the associations between migraine related disability and somatosensory amplification, depression, anxiety, and stress. Fifty-five migraine patients who applied to the outpatient unit of the Neurology Department of Acibadem University School of Medicine, Maslak Hospital in Istanbul, Turkey, and twenty-eight subjects without migraine were recruited for the study. The participants were asked to complete a sociodemographic form, Migraine Disability Assessment Scale (MIDAS), Depression Anxiety Stress Scale, Somatosensory Amplification Scale (SSAS). Somatosensory amplification scores were significantly higher in the migraineurs than in the control group (29.85+/-6.63 vs 26.07+/-7.1Item Botulinum Toxin in Migraine Treatment(TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI DERNEGI, 2013-01-01) Aydinlar, Elif Ilgaz; Dikmen, Pinar Yalinay; Kocaman, Ayse SagduyuSince botulinum toxin might have a therapeutic effect on pain, many studies investigating the efficiency of botulinum toxin in headache treatment have been done. The most satisfying results were achieved by botulinum toxin type A (BoNT/A) in the treatment of chronic migraine. In this paper, we reviewed the clinical effectiveness of BoNT/A in migraine and included our clinical experience. In our ongoing pilot study, where we have repeated BoNT/A injections every 12 weeks, The difference in the Migraine Disability Assessment (MIDAS) scores between the first and the second injections was 61.1\%Item OnabotulinumtoxinA effectiveness on chronic migraine, negative emotional states and sleep quality: a single-center prospective cohort study(SPRINGEROPEN, 2017-01-01) Aydinlar, Elif Ilgaz; Dikmen, Pinar Yalinay; Kosak, Seda; Kocaman, Ayse SagduyuBackground: OnabotulinumtoxinA (OnabotA) is considered effective in in patients with chronic migraine (CM) who failed on traditional therapies. This study was designed to evaluate the effect of OnabotA injection series on migraine outcome, negative emotional states and sleep quality in patients with CM. Methods: A total of 190 patients with CM (mean (SD) age: 39.3 (10.2) years