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    Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units
    (BMJ PUBLISHING GROUP, 2018-01-01) Bas, Ahmet Yagmur; Demirel, Nihal; Koc, Esin; Isik, Dilek Ulubas; Hirfanoglu, Ibrahim Murat; Tunc, Turan; Sari, Fatma Nur; Karatekin, Guner; Koklu, Esad; Altunhan, Huseyin; Turgut, Hatice; Narter, Fatma; Tarakci, Nuriye; Tekgunduz, Kadir Serafettin; Ozkiraz, Servet; Aydemir, Cumhur; Ozdemir, Ahmet; Cetinkaya, Bilin; Kazanci, Ebru; Tastekin, Ayhan; Calkavur, Sebnem; Ozyurt, Banu Mutlu; Demirelli, Yasar; Asker, Huseyin Selim; Mutlu, Birgul; Uygur, Ozgun; Ozkan, Hilal; Armangil, Didem; Ozlu, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Ozcan, Beyza; Bas, Evrim Kiray; Okulu, Emel; Acunas, Betul; Celik, Ulker; Uslu, Sait Ilker; Mutlu, Mehmet; Demir, Nihat; Eroglu, Funda; Gokmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Kucuktasci, Kazim; Orman, Aysen; Comert, Serdar; Ertugrul, Sabahattin; Ustun, Nuran; Sahin, Ozlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadik; Aydemir, Ozge; Zenciroglu, Aysegul; Sarici, Dilek; Guzoglu, Nilufer; Hamilcikan, Sahin; Gursoy, Tugba; Tuzun, Funda; Ors, Rahmi; Arslan, Selda; Akdag, Arzu; Memisoglu, Asli; Yasa, Beril; Hekimoglu, Berna; Turan, Ozden; Aylanc, Hakan; Takci, Sahin; Celik, Tolga; Sahin, Suzan; Kilic, Ilknur; Kara, Caner; Tunay, Zuhal Ozen; Celik, Gokhan; Gozen, Ibrahim; Satirtav, Gunhal; Polat, Nihat; Oral, Ayse Yesim; Tokgoz, Mine; Keles, Sadullah; Bilgin, Burak; Ugurbas, Silay Canturk; Karaca, Cagatay; Keskek, Nedime Sahinoglu; Ekinci, Dilbade Yildiz; Balci, Ozlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamac, Gunay; Ture, Gamze; Yildiz, Meral; Calis, Feyza; Sizmaz, Selcuk; Sukgen, Emine; Cetin, Ebru Nevin; Ozcimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Ozal, Altan; Tufaner, Gokhan; Yucel, Ozlem Eski; Kola, Mehmet; Seven, Erbil; Ozdek, Sengul; Durukan, Ali Hakan; Kal, Ali; Celebi, Ali Riza Cenk; Koytak, Ibrahim Arif; Alacamli, Goksu; Esme, Arif; Catak, Onur; Perente, Irfan; Sahin, Alparslan; Akcakaya, Aylin Ardagil; Kiray, Gulunay; Nalcaci, Serhat; Aksoy, Umit; Bakbak, Berker; Comez, Aysegul; Gursoy, Huseyin; Kabatas, Emrah Utku; Petricli, Ikbal Seza; Yumusak, Mehmet Erhan; Kirgiz, Ahmet; Uludag, Gunay; Yaman, Aylin; Dadaci, Zeynep; Karatas, Ali; Celiker, Hande; Cebeci, Zafer; Esenulku, Mahmut Cenap; Akkoyun, Imren; Ersan, Ismail; Demir, Selim; Kadayifcilar, Sibel; Unsal, Ayse Ipek Akyuz; Hocaoglu, Mumin; Grp, T. R.-R.O.P. Study
    Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results The TR-ROP study included 6115 infants: 4964 (81\%) with a GA <= 32 weeks and 1151 (19\%) with a GA>32 weeks. Overall, 27\% had any stage of ROP and 6.7\% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4\%) of the treated infants had a BW <= 1500 g. Sixty-six (16\%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions Screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs.