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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Beken, SerdarHas files: Yes

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    Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society
    (PUBLIC LIBRARY SCIENCE, 2019-01-01) Koc, Esin; Demirel, Nihal; Bas, Ahmet Yagmur; Isik, Dilek Ulubas; Hirfanoglu, Ibrahim Murat; Tunc, Turan; Sari, Fatma Nur; Karatekin, Guner; Ozdemir, Ramazan; Altunhan, Huseyin; Cetinkaya, Merih; Ozcan, Beyza; Ozkiraz, Servet; Calkavur, Sebnem; Tekgunduz, Kadir Serafettin; Tastekin, Ayhan; Ozlu, Ferda; Ozyurt, Banu Mutlu; Ozdemir, Ahmet; Cetinkaya, Bilin; Demirelli, Yasar; Koklu, Esad; Celik, Ulker; Tarakci, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bulbul, Ali; Asker, Huseyin Selim; Uygur, Ozgun; Uslu, Ilker Sait; Ertugrul, Sabahattin; Aydemir, Cumhur; Celik, Hasan Tolga; Kucuktasci, Kazim; Arslan, Selda; Ergin, Hacer; Zenciroglu, Aysegul; Yurttutan, Sadik; Orman, Aysen; Tuncer, Oguz; Yasa, Beril; Acunas, Betul; Takci, Sahin; Gokmen, Zeynel; Ozkan, Hilal; Comert, Serdar; Ustun, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Ozge; Gursoy, Tugba; Akdag, Arzu; Memisoglu, Asli; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Ozden; Guzoglu, Nilufer; Ors, Rahmi; Kale, Yusuf; Hekimoglu, Berna; Aylanc, Hakan; Eroglu, Funda; Sahin, Suzan; Konak, Murat; Sarici, Dilek; Kilic, Ilknur; Hakan, Nilay
    Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78\% of VLBW infants survived to discharge and 48\% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7\% of infants, necrotizing enterocolitis in 9.1\%, blood culture proven late-onset sepsis (LOS) in 21.1\%, blood culture negative LOS in 21.3\%, severe intraventricular hemorrhage in 5.4\% and severe retinopathy of prematurity in 11.1\%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8\% of infants. Antenatal steroids were administered to 42.9\% of mothers. Conclusion The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs.
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    The prevalence and diagnostic criteria of health-care associated infections in neonatal intensive care units in Turkey: A multicenter point- prevalence study
    (ELSEVIER TAIWAN, 2021-01-01) Demirdag, Tugba Bedir; Koc, Esin; Tezer, Hasan; Oguz, Suna; Satar, Mehmet; Saglam, Ozge; Uygun, Saime Sunduz; Onal, Esra; Hirfanoglu, Ibrahim Murat; Tekgunduz, Kadir; Oygur, Nihal; Bulbul, Ali; Zubarioglu, Adil Umut; Ustun, Nuran; Unal, Sezin; Aygun, Canan; Karagol, Belma Saygili; Zenciroglu, Aysegul; Oncel, M. Yekta; Saglik, Adviye Cakil; Okulu, Emel; Terek, Demet; Narli, Nejat; Aliefendioglu, Didem; Gursoy, Tugba; Unal, Sevim; Turkmen, Munevver Kaynak; Narter, Fatma Kaya; Ciftdemir, Nukhet Aladag; Beken, Serdar; Cakir, Salih Cagri; Yigit, Sule; Coban, Asuman; Ecevit, Ayse; Celik, Yalcin; Kulali, Ferit
    Background: Healthcare-acquired infections (HAIs) in the neonatal period cause substantial morbidity, mortality, and healthcare costs. Our purpose was to determine the prevalence of HAIs, antimicrobial susceptibility of causative agents, and the adaptivity of the Centres for Disease Control and Prevention (CDC) criteria in neonatal HAI diagnosis. Methods: A HAI point prevalence survey was conducted in the neonatal intensive care units (NICUs) of 31 hospitals from different geographic regions in Turkey. Results: The Point HAI prevalence was 7.6\%. Ventilator-associated pneumonia (VAP) and central line-associated bloodstream infections (CLABSI) and late onset sepsis were predominant. The point prevalence of VAP was 2.1\%, and the point prevalence of CLABSI was 1.2\% in our study. The most common causative agents in HAIs were Gram-negative rods (43.0\%), and the most common agent was Klebsiella spp (24.6\%)
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    Early Postnatal Metabolic Profile in Neonates With Different Birth Weight Status: A Pilot Study
    (FRONTIERS MEDIA SA, 2021-01-01) Beken, Serdar; Abali, Saygin; Yildirim Saral, Neslihan; Guner, Bengisu; Dinc, Taha; Albayrak, Eda; Ersoy, Melike; Kilercik, Meltem; Halici, Muge; Bulbul, Ezgi; Kaya, Didem; Karabay, Melis; Ay, Zeynep Alize; Eksi, Gulten Zeynep; Benli Aksungar, Fehime; Korkmaz, Ayse; Serteser, Mustafa
    Introduction: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this study, the relationship between intrauterine growth status and early metabolomics profile was evaluated. Materials and Methods: A single-center retrospective cohort study was conducted. Three hundred and sixty-one newborn infants were enrolled into the study, and they were grouped according to their birth weight percentile as small for gestational age (SGA, n = 69), appropriate for gestational age (AGA, n = 168), and large for gestational age (LGA, n = 124) infants. In all infants, amino acid and carnitine/acylcarnitine profiles with liquid chromatography-tandem mass spectrometry (LC-MS/MS) were recorded and compared between groups. Results: LGA infants had higher levels of glutamic acid and lower levels of ornithine, alanine, and glycine (p < 0.05) when compared with AGA infants. SGA infants had higher levels of alanine and glycine levels when compared with AGA and LGA infants. Total carnitine, C0, C2, C4, C5, C10:1, C18:1, C18:2, C14-OH, and C18:2-OH levels were significantly higher and C3 and C6-DC levels were lower in SGA infants (p < 0.05). LGA infants had higher C3 and C5:1 levels and lower C18:2 and C16:1-OH levels (p < 0.05). There were positive correlations between free carnitine and phenylalanine, arginine, methionine, alanine, and glycine levels (p < 0.05). Also, a positive correlation between ponderal index and C3, C5-DC, C14, and C14:1 and a negative correlation between ponderal index and ornithine, alanine, glycine, C16:1-OH, and C18:2 were shown. Conclusion: We demonstrated differences in metabolomics possibly reflecting the energy metabolism in newborn infants with intrauterine growth problems in the early postnatal period. These differences might be the footprints of metabolic disturbances in future adulthood.
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    Extremity Necrosis Due to Intrauterine Arterial Ischemia
    (GALENOS YAYINCILIK, 2021-01-01) Beken, Serdar; Sariyilmaz, Kerim; Albayrak, Eda; Akcay, Arzu; Korkmaz, Ayse
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    Complete sternal cleft treatment in a low birth weight patient
    (BAYCINAR MEDICAL PUBL-BAYCINAR TIBBI YAYINCILIK, 2020-01-01) Temur, Bahar; Mete, Sarper; Beken, Serdar; Onalan, Mehmet Akif; Erek, Ersin
    A complete sternal cleft is a very rare congenital anomaly causing severe respiratory compromise. Surgical reconstruction options are limited, particularly in low birth weight newborns. Herein, we report a case of low birth weight premature newborn with a complete sternal cleft and its surgical treatment.
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    Neonatal Problems and Infancy Growth of Term SGA Infants: Does ``SGA'' Definition Need to Be Re-evaluated?
    (FRONTIERS MEDIA SA, 2021-01-01) Abali, Saygin; Beken, Serdar; Albayrak, Eda; Inamlik, Aysegul; Bulum, Burcu; Bulbul, Ezgi; Eksi, Gulten Zeynep; Ay, Zeynep Alize; Karabay, Melis; Kaya, Didem; Halici, Muge; Semiz, Serap; Korkmaz, Ayse
    Introduction: The exact definition of small-for-gestational-age (SGA) infant is still controversial among clinicians. In this study, we aimed to understand which definition is better in terms of establishing both early postnatal problems and growth. In this way, we compared early neonatal problems and infancy growth of term infants with birth weight (BW) < -2 SDS and with BW between 10th percentile (-1.28 SDS) and -2 SDS.Methods: A single center retrospective cohort study was conducted. Preterm infants, multiple gestations and newborns with any congenital anomalies were excluded from the study. Study group was defined as Group 1 (n = 37), infants BW < -2.00 SDS