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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Kaya, CihanHas files: Yes

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    Fertility-sparing in cancer patients
    (IMR PRESS, 2021-01-01) Karakas, Sema; Kaya, Cihan; Schafer, Sebastian Daniel; Mikus, Mislav; Terzic, Milan; Abdullaev, Bekhzod; Andrisani, Alessandra
    Objective: This review aimed to investigate and summarize the current evidence on fertility-sparing options in cancer patients. Mechanism: Fertility preservation methods are becoming popular through the improved prognosis of cancer patients at a younger age and early diagnostic tools. However, currently, more and more women are suffering from iatrogenic ovarian failure and fertility loss because of cancer treatment. Most treatments have been used for hematological malignancies, but different gynecological cancers can be eligible. Findings in brief: Fertility preserving strategies such as oocyte and embryo cryopreservation, ovarian tissue preservation, ovarian transposition, and aspiration of ovarian follicles are the methods that could be suggestedto the patients. The current knowledge supports oocyte and embryo cryopreservation as feasible, safe, and effective treatment approaches for cancer patients seeking fertility preservation. Conclusions: Robust evidence is still needed to prove the effectiveness of cryopreservation of the ovarian tissue and ovarian follicle aspiration approaches since these techniques are still in early their steps.
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    The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients
    (MARMARA UNIV, FAC MEDICINE, 2022-01-01) Topbas Selcuki, Nura Fitnat; Yalcin Bahat, Pinar; Kaya, Cihan; Neselioglu, Salim; Bagci, Kubra; Goksu, Mustafa; Kabakci, Merle; Erel, Ozcan
    Objective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels. Patients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group. Thiol/disulfide parameters and IMA levels were determined from the serum samples. Results: When the thiol/disulfide parameters were compared between the study and the control group no significant difference was observed (p=0.49). Mean disulfide level in the control group was 18.58 +/- 5.73 mu mol/L, and in the study group was 18.61 +/- 7.37 mu mol/L. Levels were statistically similar in both groups (p=0.98). In addition, there were no differences between the groups in terms of IMA and albumin levels. Conclusion: The results of this study revealed no significant difference in the dynamic thiol/disulfide homeostasis among the endometriosis patients. Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.