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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Sahiner, MelikeHas files: No

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    Pharmacologically induced absence seizures versus kindling in Wistar rats
    (KARE PUBL, 2020-01-01) Carcak, Nihan; Sahiner, Melike; Akman, Ozlem; Idrizoglu, Medine Gulcebi; Cortez, Miguel A.; Snead, O. Carter; Eskazan, Esat; Onat, Filiz
    OBJECTIVE: This study aimed to investigate the effects of gamma-butyrolactone (GBL), a prodrug of gamma-Hydroxybutyric acid-induced absence seizures on the development of kindling in Wistar rats. METHODS: Three groups of adult male Wistar rats under anesthesia were implanted with bilateral cortical recording elec- trodes for the GBL group (GBL) and/or bipolar stimulation electrodes into the right basolateral amygdala for the Kindling group (KI) alone and Kindling plus GBL group (GBL+KI). Rats in the KI and GBL+KI groups were stimulated twice daily at the afterdischarge threshold until they reached Racine's stage 5 seizure state. The animals in the GBL + group had an i.p injection of GBL 20 minutes before each electrical stimulation, and the effects of GBL-induced seizures on the development of kindling were investigated. The animals in the GBL group were injected GBL twice daily i.p. for 15 days without receiving any electrical stimulation. RESULTS: The KI animals reached stage 5 seizure stage at 12th stimulations, whereas the GBL+KI rats reached at 27th stimulations. The mean numbers of stimulations needed for the development of the first stage 3, 4, or 5 generalized seizures were significantly higher in the GBL+KI group than the KI group. CONCLUSION: The resistance to amygdala kindling in the GBL model can be modulated by the absence seizure mechanism alone, without the intervention of an abnormal genetic background.
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    An overview of the post-graduate physiology education in Turkey
    (DEOMED PUBL, ISTANBUL, 2017-01-01) Bor-Kucukatay, Melek; Sahiner, Melike; Yegen, Berrak C.
    A questionnaire was prepared to determine the current situation, characteristics, main problems and solution proposals of post-graduate physiology education in Turkey. The questionnaire was answered by 40\% of the physiology departments with post-graduate programs. The results of the questionnaire demonstrate that 31\% of master students and 45\% of PhD students have academic positions. Most of the post-graduate physiology students are employed in the ``academic staff training program{''} (62\% of master and 59\% of PhD students). Post-graduate physiology students were mainly composed of biologists (25\%) and medical doctors (21\%). All or the majority (81\%) of postgraduate students have completed their education within the legal periods. We have observed that post-graduate physiology students do not sufficiently benefit from the national and international student exchange programs, scholarships and do not participate in academic activities. Publication rates of the post-graduate thesis in national and international journals are also below the anticipated level. The general problems faced in providing post-graduate physiology education are insufficiency of available academic positions, scholarships, number of academic staff, inadequate financial support in producing qualified research as well as lack of infrastructure. The results of the questionnaire demonstrate that comprehensive studies with broad participation are necessary in order to improve post-graduate education in our country.