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Permanent URI for this collectionhttps://hdl.handle.net/11443/932
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Item The positive impact of platelet-derived growth factor on the repair of full-thickness defects of articular cartilage(TURKISH JOINT DISEASES FOUNDATION, 2019-01-01) Sarban, Sezgin; Tabur, Hasan; Baba, Z. Fusun; Isikan, U. ErdemObjectives: This study aims to investigate the potential use and histological effects of the local administration of platelet-derived growth factor (PDGF) in the repair of full-thickness osteochondral defects in articular cartilage in an animal model. Materials and methods: Twenty-four adolescent 18-week-old New Zealand White rabbits with an average weight of 2500 g (range, 1600 g to 3200 g) were used in the study. The rabbits were randomly divided into three groups (n=8) as the control group (group A) and two experimental groups (groups Band C). Defects of cylindrical full-thickness (3.5 mm wide, 4 mm deep) were created in the weight-bearing area of the right knee medial femoral condyles. In group A, the defect was left empty. In group B, the defect was filled with a collagen sponge. In group C, the defect was filled with a collagen sponge impregnated with PDGF. All rabbits were followed-up for 12 weeks. Right knee medial femoral condyles were used for macroscopic and histological analyses. Results: At macroscopic level, the repair tissue was similar to normal adjacent cartilage at 12 weeks in group C. The surface of the repair tissue in group C was smoother and more regular compared to groups A and B. The total histological score of defects in group C was statistically significantly superior compared to groups A and B (p<0.05). Matrix staining and immunostaining of collagen type 2 were stronger in group C compared to the other groups, indicating the presence of a tissue similar to a normal cartilage. Conclusion: Platelet-derived growth factor can induce repair in full-thickness defects of articular cartilage in an animal model. Thus, this study demonstrates the potential use of PDGF for full-thickness osteochondral defects.Item Minimal invasive fixation of distal tibial fractures does not result in rotational malalignment: A report of 24 cases with CT imaging(TURKISH ASSOC TRAUMA EMERGENCY SURGERY, 2017-01-01) Sonmez, Mehmet Mesut; Gulabi, Deniz; Ugurlar, Meric; Uzun, Metin; Sarban, Sezgin; Seker, AliBACKGROUND: Tibial torsion is rotation of the proximal versus the distal articular axis in the transverse plane. This study used computed tomography (CT) to examine rotational malalignment in the crus following use of minimally invasive plate osteosynthesis (MIPO) technique in distal tibial fractures and evaluated effect of rotational difference on clinical outcomes and VAS scores. METHODS: Analysis of 24 patients who were operated on for closed distal tibial fracture with MIPO technique between 2010 and 2012 was conducted. Malrotation was defined as rotational difference > 10 degrees. Operated knees were evaluated with 0.5-mm, fine-cut, 3-dimensional CT scan performed in cooperation with radiology department. Side-to-side difference in tibial torsion angle > 10 degrees was considered significant degree of malrotation. All patients were assessed clinically (visual analogue scale {[}VAS] and American Orthopaedic Foot and Ankle Society {[}AOFAS] scores) and radiologically at final visit. RESULTS: Mean follow-up period was 20.00 +/- 9.46 months (range: 18-51 months). Mean VAS score was 2.58 +/- 0.83 (range: 1-4) and mean AOFAS score was 87.50 +/- 4.05 (range: 78-93). Mean tibial rotation angle was 31.54 +/- 6.00 degrees (range: 18-45 degrees) on healthy side and 32.00 +/- 6.24 degrees (range: 10-43 degrees) on the operated side. No statistically significant difference was determined (p > 0.05). CONCLUSION: Use of intraoperative fluoroscopy, cable technique, and uninjured extremity as reference, can reduce incidence of rotational malalignment of distal tibial fractures treated with MIPO.