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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Ketamine With and Without Midazolam for Emergency Department Sedation in Adults: A Randomized Controlled Trial
(MOSBY-ELSEVIER, 2011-01-01) Sener, Serkan; Eken, Cenker; Schultz, Carl H.; Serinken, Mustafa; Ozsarac, Murat
Study objective: We assess whether midazolam reduces recovery agitation after ketamine administration in adult emergency department (ED) patients and also compared the incidence of adverse events (recovery agitation, respiratory, and nausea/vomiting) by the intravenous (IV) versus intramuscular (IM) route. Methods: This prospective, double-blind, placebo-controlled, 2x2 factorial trial randomized consecutive ED patients aged 18 to 50 years to 4 groups: receiving either 0.03 mg/kg IV midazolam or placebo, and with ketamine administered either 1.5 mg/kg IV or 4 mg/kg IM. Adverse events and sedation characteristics were recorded. Results: Of the 182 subjects, recovery agitation was less common in the midazolam cohorts (8\% versus 25\%