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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Serdar, MuhittinHas files: No

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    Determination of Age-Dependent Reference Ranges for Coagulation Tests Performed Using Destiny Plus
    (KOWSAR CORP, 2016-01-01) Arslan, Fatma Demet; Serdar, Muhittin; Ari, Elif Merve; Oztan, Mustafa Onur; Kozcu, Sureyya Hikmet; Tarhan, Huseyin; Cakmak, Ozgur; Zeytinli, Merve; Ellidag, Hamit Yasar
    Background: In order to apply the right treatment for hemostatic disorders in pediatric patients, laboratory data should be interpreted with age-appropriate reference ranges. Objectives: The purpose of this study was to determining age-dependent reference range values for prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen tests, and D-dimer tests. Materials and Methods: A total of 320 volunteers were included in the study with the following ages: 1 month - 1 year (n = 52), 2 - 5 years (n = 50), 6 - 10 years (n = 48), 11 - 17 years (n = 38), and 18 - 65 years (n = 132). Each volunteer completed a survey to exclude hemostatic system disorder. Using a nonparametric method, the lower and upper limits, including 95\% distribution and 90\% confidence intervals, were calculated. Results: No statistically significant differences were found between PT and aPTT values in the groups consisting of children. Thus, the reference ranges were separated into child and adult age groups. PT and aPTT values were significantly higher in the children than in the adults. Fibrinogen values in the 6 - 10 age group and the adult age group were significantly higher than in the other groups. D-dimer levels were significantly lower in those aged 2 - 17
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    Changes in Proinflammatory Cytokines in the Cochlea in Relation to Hearing Thresholds in Noise-Exposed Rats
    (AVES, 2017-01-01) Arslan, Hasan Huseyin; Satar, Bulent; Serdar, Muhittin; Yilmaz, Emine
    OBJECTIVE: Our aim was to investigate time effects in proinflammatory cytokines and the auditory brainstem response (ABR) thresholds of rat cochlea exposed to noise. MATERIALS and METHODS: Twenty-one rats were divided into two groups: the control group and the noise group. As high as 115 dB sound pressure of white noise was administered to the noise group of 16 rats for 3 h a day for 10 days. This group was further split into four subgroups based on the timing of sacrifice: 3rd hour group, 12th hour group, 24th hour group, and 28th day group. ABR thresholds were measured in all the rats, after the noise exposure and right before being sacrificed. Proinflammatory cytokine levels (IL-6, IL-1 beta, and TNF-alpha) at the cochlea were measured. RESULTS: We found a significant difference between the first ABR thresholds (5 dB nHL) and the post-exposure ABR thresholds in each group (25 dBnHL, 35 dBnHL, 15 dBnHL, and 17.50 dBnHL for the 3rd hour group, 12th hour group, 24th hour group, and 28th day group, respectively). The IL-1 beta levels in the 3rd hour group and 12th hour group were significantly higher than those in the control group and other noise subgroups. The TNF-alpha level in the 3rd hour group was significantly higher than that in the control group and other noise subgroups. CONCLUSION: It seems reasonable to point out a direct correlation between the cytokine levels and hearing threshold levels after the noise exposure. This correlation was the highest for IL-1 beta. This result suggested a significant role of proinflammatory cytokines in hearing deterioration after noise exposure.
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    Effect of smoking on salivary free amino acid levels
    (EUROPEAN PUBLISHING, 2018-01-01) Tas, Duygu; Onder, Canan; Kurgan, Sivge; Mammadov, Cavid; Serdar, Muhittin
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    Association of vitamin D receptor polymorphisms and type 1 diabetes susceptibility in children: a meta-analysis
    (BIOSCIENTIFICA LTD, 2017-01-01) Sahin, Ozlem Atan; Goksen, Damla; Ozpinar, Aysel; Serdar, Muhittin; Onay, Huseyin
    Background: There have been studies focused on FokI, BsmI, ApaI and TaqI polymorphisms of the vitamin D receptor (VDR) gene and susceptibility to type 1 diabetes mellitus with controversial results. Methods: This present study is a meta-analysis investigating the association between FokI, ApaI, TaqI and BsmI polymorphisms of VDR gene and type 1 DM in children. A literature search was performed using Medline, EMBASE, Cochrane and PubMed. Any study was considered eligible for inclusion if at least one of FokI, ApaI, TaqI and BsmI polymorphisms was determined, and outcome was type 1 DM at pediatric age. Results: A total of 9 studies comprising 1053 patients and 1017 controls met the study inclusion criteria. The pooled odds ratios (ORs) of the FokI, ApaI, TaqI and BsmI polymorphisms were combined and calculated. Forest plots and funnel plots of the OR value distributions were drawn. Our meta-analysis has demonstrated statistically significant associations between DM1 and VDR genotypes, BsmIBB (P < 0.05), BsmIBb, (P < 0.05), BsmIbb (P < 0.05), TaqITT (P < 0.05) and TaqItt (P < 0.05) in children. Conclusion: The results indicated that BsmIBB, BsmIBb and TaqItt polymorphisms were associated with an increased risk of type 1 DM, whereas BsmIbb and TaqITT had protective effect for type 1 DM in children.