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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Author: search.filters.author.Soylemezoglu, FigenHas files: Yes

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    Towards Development of a Standard Terminology of the World Health Organization Classification of Tumors of the Central Nervous System in the Turkish Language, and a Perspective on the Practical Implications of the WHO Classification for Low and Middle Income Countries
    (FEDERATION TURKISH PATHOLOGY SOC, 2022-01-01) Soylemezoglu, Figen; Oz, Buge; Egilmez, Reyhan; Pekmezci, Melike; Bozkurt, Suheyla; Danyeli, Ayca Ersen; Onguru, Onder; Kulac, Ibrahim; Tihan, Tarik
    In our manuscript, we propose a common terminology in the Turkish language for the newly adopted WHO classification of the CNS tumors, also known as the WHO CNS 5th edition. We also comment on the applicability of this new scheme in low and middle income countries, and warn about further deepening disparities between the global north and the global south. This division, augmented by the recent COVID-19 pandemic, threatens our ability to coordinate efforts worldwide and may create significant disparities in the diagnosis and treatment of cancers between the ``haves{''} and the ``have nots{''}.
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    Evaluation of the `Hedgehog' signaling pathways in squamous and basal cell carcinomas of the eyelids and conjunctiva
    (SPANDIDOS PUBL LTD, 2016-01-01) Celebi, Ali Riza Cenk; Kiratli, Hayyam; Soylemezoglu, Figen
    The purpose of the present study was to assess the role of hedgehog signaling pathway in the carcinogenesis of eyelid skin and conjunctival epithelial malignant tumors. The study was conducted on specimens from 41 patients with cutaneous eyelid basal cell carcinoma, 22 with bulbar conjunctival squamous cell carcinoma, 12 with bulbar conjunctival intraepithelial neoplasia. Major molecules of Hedgehog signaling pathway (Sonic Hedgehog {[}Shh] and Patched-1 {[}Ptch-1] and Glioma-associated oncogene {[}Gli-1]) were evaluated in paraffin-embedded tissue specimens using immunohistochemical staining. For each specimen, the percentage (<10\%, 10-50\%, > 50\%) and the intensity of the immunohistochemical staining (graded from 0 to 3) were calculated and the scores obtained by multiplication of two values were analyzed using the Kruskall-Wallis test. Shh and Ptch-1 expression levels were statistically significantly lower in the basal cell carcinoma group compared with the squamous cell carcinoma group (P= 0.043 for Shh