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    Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
    (ELSEVIER SCI LTD, 2018-01-01) Bhangu, Aneel; Ademuyiwa, Adesoji O.; Aguilera, Maria Lorena; Alexander, Philip; Al-Saqqa, Sara W.; Borda-Luque, Giuliano; Costas-Chavarri, Ainhoa; Drake, Thomas M.; Ntirenganya, Faustin; Fitzgerald, J. Edward; Fergusson, Stuart J.; Glasbey, James; Ingabire, J. C. Allen; Ismail, Lawani; Salem, Hosni Khairy; Kojo, Anyomih Theophilus Teddy; Lapitan, Marie Carmela; Lilford, Richard; Mihaljevic, Andre L.; Morton, Dion; Mutabazi, Alphonse Zeta; Nepogodiev, Dmitri; Adisa, Adewale O.; Ots, Riinu; Pata, Francesco; Pinkney, Thomas; Poskus, Tomas; Qureshi, Ahmad Uzair; Ramos-De la Medina, Antonio; Rayne, Sarah; Shaw, Catherine A.; Shu, Sebastian; Spence, Richard; Smart, Neil; Tabiri, Stephen; Harrison, Ewen M.; Bhangu, Anna; Harrison, Ewen M.; Verjee, Azmina; Runigamugabo, Emmy; Khatri, Chetan; Mohan, Midhun; Drake, Thomas M.; Glasbey, James; Nepogodiev, Dmitri; Shaw, Catherine A.; Jaffry, Zahra; Fergusson, Stuart J.; Pata, Francesco; Ademuyiwa, Adesoji O.; Altamini, Afnan; Salem, Hosni Khairy; Kirby, Andrew; Soreide, Kjetil; Recinos, Gustavo; Spence, Richard; Rayne, Sarah; Tabiri, Stephen; Cornick, Jen; Pinkney, Thomas; Lilford, Richard; Fitzgerald, J. Edward; Harrison, Ewen M.; Bhangu, Aneel; Modolo, Maria Marta; Iyer, Dushyant; King, Sebastian; Arthur, Tom; Nahar, Sayeda Nazmum; Waterman, Ade; Ismail, Lawani; Walsh, Michael; Agarwal, Arnav; Zani, Augusto; Firdouse, Mohammed; Rouse, Tyler; Liu, Qinyang; Correa, Juan Camilo; Salem, Hosni Khairy; Talving, Peep; Worku, Mengistu; Arnaud, Alexis; Tabiri, Stephen; Kalles, Vassilis; Aguilera, Maria Lorena; Recinos, Gustavo; Kumar, Basant; Kumar, Sunil; Amandito, Radhian; Quek, Roy; Pata, Francesco; Ansaloni, Luca; Altibi, Ahmed; Venskutonis, Donatas; Zilinskas, Justas; Poskus, Tomas; Whitaker, John; Msosa, Vanessa; Tew, Yong Yong; Farrugia, Alexia; Borg, Elaine; Ramos-De la Medina, Antonio; Bentounsi, Zineb; Gala, Tanzeela; Al-Slaibi, Ibrahim; Tahboub, Haya; Alser, Osaid H.; Romani, Diego; Shu, Sebestian; Major, Piotr; Mironescu, Aurel; Bratu, Matei; Kourdouli, Amar; Ndajiwo, Aliyu; Altwijri, Abdulaziz; Alsaggaf, Mohammed Ubaid; Gudal, Ahmad; Jubran, Al Faifi; Seisay, Sam; Lieske, Bettina; Rayne, Sarah; Spence, Richard; Ortega, Irene; Jeyakumar, Jenifa; Senanayake, Kithsiri J.; Abdulbagi, Omar; Cengiz, Yucel; Raptis, Dmitri; Altinel, Yuksel; Kong, Chia; Teasdale, Ella; Irwin, Gareth; Stoddart, Michael; Kabariti, Rakan; Suresh, Sukrit; Gash, Katherine; Narayanan, Ragavan; Maimbo, Mayaba; Grizhja, Besmir; Ymeri, Shpetim; Galiqi, Gezim; Klappenbach, Roberto; Antezana, Diego; Beleno, Alvaro Enrique Mendoza; Costa, Cecilia; Sanchez, Belen; Aviles, Susan; Modolo, Maria Marta; Fermani, Claudio Gabriel; Balmaceda, Ruben; Villalobos, Santiago; Carmona, Juan Manuel; Hamill, Daniel; Deutschmann, Peter; Sandler, Simone; Cox, Daniel; Nataraja, Ram; Sharpin, Claire; Ljuhar, Damir; Gray, Demi; Haines, Morgan; Iyer, Dush; Niranjan, Nithya; D'Amours, Scott; Ashtari, Morvarid; Franco, Helena; Mitul, Ashrarur Rahman; Karim, Sabbir; Aman, Nowrin F.; Estee, Mahnuma Mahfuz; Salma, Umme; Razzaque, Joyeta; Kanta, Tasnia Hamid; Tori, Sayeeda Aktar; Alamin, Shadid; Roy, Swapnil; Al Amin, Shadid; Karim, Rezaul; Haque, Muhtarima; Faruq, Amreen; Iftekhar, Farhana; O'Shea, Margaret; Padmore, Greg; Jonnalagadda, Ramesh; Litvin, Andrey; Filatau, Aliaksandr; Paulouski, Dzmitry; Shubianok, Maryna; Shachykava, Tatsiana; Khokha, Dzianis; Khokha, Vladimir; Djivoh, Fernande; Ismail, Lawani; Dossou, Francis; Seto, Djifid Morel; Gbessi, Dansou Gaspard; Noukpozounkou, Bruno; Souaibou, Yacoubou Imorou; Keke, Kpemahouton Rene; Hodonou, Fred; Ahounou, Ernest Yemalin Stephane; Alihonou, Thierry; Denakpo, Max; Ahlonsou, Germain; Bedada, Alemayehu Ginbo; Nsengiyumva, Carlos; Kwizera, Sandrine; Barendegere, Venerand; Choi, Philip; Stock, Simon; Jamal, Luai; Firdouse, Mohammed; Zani, Augusto; Azzie, Georges; Kushwaha, Sameer; Agarwal, Arnav; Chen, Tzu-Ling; Yip, Chingwan; Montes, Irene; Zapata, Felipe; Sierra, Sebastian; Lanau, Maria Isabel Villegas; Arango, Maria Clara Mendoza; Restrepo, Ivan Mendoza; Giraldo, Ruben Santiago Restrepo; Domini, Edgar; Karlo, Robert; Mihanovic, Jakov; Youssef, Mohamed; Elfeki, Hossam; Thabet, Waleed; Sanad, Aly; Tawfik, Gehad; Zaki, Ahmed; Abdel-Hameed, Noran; Mostafa, Mohamed; Omar, Muhammad Fathi Waleed; Ghanem, Ahmed; Abdallah, Emad; Denewar, Adel; Emara, Eman; Rashad, Eman; Sakr, Ahmad; Elashry, Rehab; Emile, Sameh; Khafagy, Toqa; Elhamouly, Sara; Elfarargy, Arwa; Mohamed, Amna Mamdouh; Nagy, Ghada Saied; Esam, Abeer; Elwy, Eman; Hammad, Aya; Khallaf, Salwa; Ibrahim, Eman; Saidbadr, Ahmed; Moustafa, Ahmed; Mohammed, Amany Eldosouky; Elgheriany, Mohammed; Abdelmageed, Eman; Al Raouf, Eman Abd; Elbanby, Esraa Samir; Elmasry, Maha; Farahat, Mahitab Morsy; Mansor, Eman Yahya; Hegazy, Eman Magdy; Gamal, Esraa; Gamal, Heba; Kandil, Hend; Abdelrouf, Doaa Maher; Moaty, Mohamed; Gamal, Dina; El-Sagheer, Nada; Salah, Mohamed; Magdy, Salma; Salah, Asmaa; Essam, Ahmed; Ali, Ahmed; Badawy, Mahmoud; Ahmed, Sara; Mohamed, Mazed; Assal, Abdelrahman; Sleem, Mohamed; Ebidy, Mai; Elrazek, Aly Abd; Zahran, Diaaaldin; Adam, Nourhan; Nazir, Mohamed; Hassanein, Adel B.; Ismail, Ahmed; Elsawy, Amira; Mamdouh, Rana; Mabrouk, Mohamed; Ahmed, Lopna Ahmed Mohamed; Alnaby, Mohamed Hassab; Magdy, Eman; Abd-Elmawla, Manar; Fahim, Marwan; Mowafy, Bassant; Mahmoud, Moustafa Ibrahim; Allam, Meran; Alkelani, Muhammad; El Gendy, Noran Halim; Aboul-Naga, Mariam Saad; El-Din, Reham Alaa; Elgendy, Alyaa Halim; Ismail, Mohamed; Shalaby, Mahmoud; Elsharkawy, Aya Adel; Moghazy, Mahmoud Elsayed; Elbisomy, Khaled Hesham; Shakshouk, Hend Adel Gawad; Hamed, Mohamed Fouad; Ebidy, Mai Mohamed; Abdelkader, Mostafa; Karkeet, Mohamed; Ahmed, Hayam; Adel, Israa; Omar, Mohammad Elsayed; Ibrahim, Mohamed; Ghoneim, Omar; Hesham, Omar; Gamal, Shimaa; Hilal, Karim; Arafa, Omar; Awad, Sawsan Adel; Salem, Menatalla; Elsherif, Fawzia Abdellatif; Elsabbagh, Nourhan; Aboelsoud, Moustafa R.; Rida, Ahmed Hossam Eldin Fouad; Hossameldin, Amr; Hany, Ethar; Asar, Yomna Hosny; Anwar, Nourhan; Gadelkarim, Mohamed; Abdelhady, Samar; Morshedy, Eman Mohamed; Saad, Reham; Soliman, Nourhan; Salama, Mahmoud; Ezzat, Eslam; Mohamed, Arwa; Ibrahim, Arwa; Fergany, Alaa; Mohammed, Sara; Reda, Aya; Allam, Yomna; Saad, Hanan Adel; Abdelfatah, Afnan; Fathy, Aya Mohamed; El-Sehily, Ahmed; Kasem, Esraa Abdalmageed; Hassan, Ahmed Tarek Abdelbaset; Mohammed, Ahmed Rabeih; Saad, Abdalla Gamal; Elfouly, Yasmin; Elfouly, Nesma; Ibrahim, Arij; Hassaan, Amr; Mohammed, Mustafa Mohammed; Elhoseny, Ghada; Magdy, Mohamed; Abd Elkhalek, Esraa; Zakaria, Yehia; Ezzat, Tarek; El Dahab, Ali Abo; Kelany, Mohamed; Arafa, Sara; Hassan, Osama Mokhtar Mohamed; Badwi, Nermin Mohamed; Sleem, Ahmad Saber; Ahmed, Hussien; Abdelbadeai, Kholoud; Abdullah, Mohamed Abozed; Lokman, Muhammad Amsyar Auni; Bahar, Suraya; Abdelazeam, Anan Rady; Adelshone, Abdelrahman; Bin Hasnan, Muhammad; Zulkifli, Athirah; Kamarulzamil, Siti Nur Alia; Elhendawy, Abdelaziz; Latif, Aliang; Bin Adnan, Ahmad; Shaharuddin, Shahadatul; Majid, Aminah Hanum Haji Abdul; Amreia, Mahmoud; Al-Marakby, Dina; Salma, Mahmoud; Bin Ismail, Mohamad Jeffrey; Basir, Elissa Rifhan Mohd; Ali, Citra Dewi Mohd; Ata, Aya Yehia; Nasr, Maha; Rezq, Asmaa; Sheta, Ahmed; Tariq, Sherif; Sallam, Abd Elkhalek; Darwish, Abdelrhman K. Z.; Elmihy, Sohaila; Elhadry, Shady; Farag, Ahmed; Hajeh, Haidar; Abdelaal, Abdelaziz; Aglan, Amro; Zohair, Ahmed; Essam, Mahitab; Moussa, Omar; El-Gizawy, Esraa; Samy, Mostafa; Ali, Safia; Elhalawany, Esraa; Ata, Ahmed; El Halawany, Mohamed; Nashat, Mohamed; Soliman, Samar; Elazab, Alaa; Samy, Mostada; Abdelaziz, Mohamed A.; Ibrahim, Khaled; Ibrahim, Ahmed Mohamed; Gado, Ammar; Hantour, Usama; Eldeen, Esraa Alm; loaloa, Mohamed Reda; Abouzaid, Arwa; Eldin, Mostafa Ahmed Bahaa; Hashad, Eman; Sroor, Fathy; Gamil, Doaa; Abdulhakeem, Eman Mahmoud; Zakaria, Mahmoud; Mohamed, Fawzy; Abubakr, Marwan; Ali, Elsayed; Magdy, Hesham; Ramadan, Menna Tallah; Mohamed, Mohamed Abdelaty; Mansour, Salma; Amin, Hager Abdul Aziz; Mohamed, Ahmed Rabie; Saami, Mahmoud; Elsayed, Nada Ahmed Reda; Tarek, Adham; Mahmoud, Sabry Mohy Eldeen; El Sayed, Islam Magdy; Reda, Amira; Shawky, Martina Yusuf; Salem, Mohammed Mousa; El-Din, Shahinaz Alaa; Soliman, Noha Abdullah; Talaat, Muhammed; AlaaelDein, Shahinaz; Elhusseiny, Ahmed Abd Elmoen; Abdullah, Noha; Elshaar, Mohammed; Ibraheem, Aya AbdelFatah; Abdulaziz, Hager; Ismail, Mohammed Kamal; Madkor, Mona Hamdy; Abdelaty, Mohamed; Abdel-Kader, Sara Mahmoud; Salah, Osama Mohamed; Eldafrawy, Mahmoud; Eldeeb, Ahmed Zaki; Eid, Mostafa Mahmoud; Attia, Attia; El-Dien, Khalid Salah; Shwky, Ayman; Badenjki, Mohamed Adel; Soliman, Abdelrahman; Al Attar, Samaa Mahmoud; Sayed, Farrag; Sabour, Fahd Abdel; Azizeldine, Mohammed G.; Shawqi, Muhammad; Hashim, Abdullah; Aamer, Ahmed; Abdelraouf, Ahmed Mahmoud; Abdelshakour, Mahmoud; Ibrahim, Amal; Mahmoud, Basma; Mahmoud, Mohamed Ali; Qenawy, Mostafa; Rashed, Ahmed M.; Dahy, Ahmed; Sayed, Marwa; Shamsedine, Ahmed W.; Mohamed, Bakeer; Hasan, Ahmad; Saad, Mahmoud M.; Bassit, Khalil Abdul; Abd El-Latif, Nadia Khalid; Elzahed, Nada; El Kashash, Ahmed; Bekhet, Nada Mohamed; Hafez, Sarah; Gad, Ahmed; Maher, Mahmoud Elkhadragy; Elsameea, Ahmed Abd; Hafez, Mohamed; Sabe, Ahmad; Ahmed, Ataa; Shahine, Ahmed; Dawood, Khaled; Gaafar, Shireen; Husseiny, Reem; Aboelmagd, Omnia; Soliman, Ahmed; Mesbah, Nourhan; Emadeldin, Hossam; Al Meligy, Amgad; Bekhet, Amira Hassan; Hasan, Doaa; Alhady, Khaled; Sabe, Ahmad Khaled; Elnajjar, Mahmoud A.; Aboelella, Majed; Hamsho, Ward; Hassan, Ihab; Saad, Hala; Abdelazim, Galaleldin; Mahmoud, Hend; Wael, Noha; Kandil, Ahmedali M.; Magdy, Ahmed; Elkholy, Shimaa Said; Adel, Badr Eldin; Dabbour, Kareem; Elsherbiney, Saged; Mattar, Omar; Abdrabou, Abdulshafi Khaled; Aly, Mohammed Yahia Mohamed; Geuoshy, Abdelrahman; Elnagar, Ahmedglal; Ahmed, Saraibrahim; Abdelmotaleb, Ibrahem; Saleh, Amr Ahmed; Saeed, Manar; Mahmoud, Shady; Tawfik, Badreldin Adel; Ismail, Samar Adel; Zakaria, Esraay; Gad, Mariam O.; Elhelbawy, Mohamed Salah; Bassem, Monica; Maraie, Noha; Elhadary, Nourhan Medhat; Semeda, Nourhan; Mohamed, Shaza Rabie; Bakry, Hesham Mohammed; Essam, A. A.; Tarek, Dina; Ashour, Khlood; Elhadad, Alaa; Abdel-Aty, Abdulrahman; Rakha, Ibrahim; Matter, Sara Mamdouh; Abdelhamed, Rasha; Abdelkader, Omar; Hassaan, Ayat; Soliman, Yasmin; Mohamed, Amna; Ghanem, Sara; Farouk, Sara Amr Mohamed; Ibrahim, Eman Mohamed; El-Taher, Esraa; Mostafa, Merna; Badr, Mohamed Fawzy Mahrous; Elsemelawy, Rofida; El-Sawy, Aya; Bakr, Ahmad; Al Rafati, Ahmad Abdel Razaq; Saar, Sten; Reinsoo, Arvo; Talving, Peep; Seyoum, Nebyou; Worku, Tewodros; Fitsum, Agazi; Tolonen, Matti; Leppaniemi, Ari; Sallinen, Ville; Parmentier, Benoit; Peycelon, Matthieu; Irtan, Sabine; Dardenne, Sabrina; Robert, Elsa; Maillot, Betty; Courboin, Etienne; Arnaud, Alexis Pierre; Hascoet, Juliette; Abbo, Olivier; Kaci, Amir Ait; Prudhomme, Thomas; Ballouhey, Quentin; Grosos, Celine; Fourcade, Laurent; Cecilia, Tolg; Jean-Francois, Colombani; Helene, Francois-Coridon; Delforge, Xavier; Haraux, Elodie; Dousset, Bertrand; Schiavone, Roberto; Gaujoux, Sebastien; Marret, Jean-Baptiste; Haffreingue, Aurore; Rod, Julien; Renaux-Petel, Mariette; Lecompte, Jean-Francois; Breaud, Jean; Gastaldi, Pauline; Taieb, Chouikh; Claire, Raquillet; Anis, Echaieb; Bustangi, Nasir; Lopez, Manuel; Scalabre, Aurelien; Bustangi, Nasir; Lopez, Manuel; Scalabre, Aurelien; Grella, Maria Giovanna; Mariani, Aurora; Podevin, Guillaume; Schmitt, Francoise; Hervieux, Erik; Broch, Aline; Muller, Cecile; Tabiri, Stephen; Kojo, Anyomih Theophilus Teddy; Bandoh, Dickson; Abantanga, Francis; Kyereh, Martin; Asumah, Hamza; Appiah, Eric Kofi; Wondoh, Paul; Gyedu, Adam; Dally, Charles; Agbedinu, Kwabena; Amoah, Michael; Yifieyeh, Abiboye; Owusu, Frank; Amoako-Boateng, Mabel; Dayie, Makafui; Hagan, Richmond; Debrah, Sam; Ohene-Yeboah, Micheal; Clegg-Lampety, Joe-Nat; Etwire, Victor; Dakubo, Jonathan; Essoun, Samuel; Bonney, William; Glover-Addy, Hope; Osei-Nketiah, Samuel; Amoako, Joachim; Adu-Aryee, Niiarmah; Appeadu-Mensah, William; BediakoBowan, Antoinette; Dedey, Florence; Yakubu, Musah; Kordorwu, Hope Edem Kofi; Asare-Bediako, Kwasi; Tackie, Enoch; Aaniana, Kenneth; Acquah, Emmanuel; Opoku-Agyeman, Richard; Avoka, Anthony; Kusi, Kwasi; Maison, Kwame; Gyamfi, Frank Enoch; Barnabas, Gandau Naa; Abdul-Latif, Saiba; Amoako, Philip Taah; Davor, Anthony; Dassah, Victor; Dagoe, Enoch; Kwakyeafriyie, Prince; Akoto, Elliot; Ackom, Eric; Mensah, Ekow; Atkins, Ebenezer Takyi; Coompson, Christian Lari; Ivros, Nikolaos; Ferousis, Christoforos; Kalles, Vasileios; Agalianos, Christos; Kyriazanos, Ioannis; Barkolias, Christos; Tselos, Angelos; Tzikos, Georgios; Voulgaris, Evangelos; Lytras, Dimitrios; Bamicha, Athanasia; Psarianos, Kyriakos; Stefanopoulos, Anastasios; Patoulias, Ioannis; Sfougaris, Dimitrios; Valioulis, Ioannis; Balalis, Dimitrios; Korkolis, Dimitrios; Manatakis, Dimitrios K.; Kyrou, Georgios; Karabelias, Georgios; Papaskarlatos, IasonAntonios; Konstantina, Kolonia; Zampitis, Nikolaos; Germanos, Stylianos; Papailia, Aspasia; Theodosopoulos, Theodosios; Gkiokas, Georgios; Mitroudi, Magdalini; Panteli, Christina; Feidantsis, Thomas; Kyziridis, Dimitrios; Ioannidis, Orestis; Parpoudi, Styliani; Gemenetzis, Georgios; Parasyris, Stavros; Anthoulakis, Christos; Nikoloudis, Nikolaos; Margaritis, Michail; Aguilera-Arevalo, Maria-Lorena; Coyoy-Gaitan, Otto; Rosales, Javier; Tale, Luis; Soley, Rafael; Barrios, Emmanuel; Torres Rodriguez, Servio Tulio; Paz Galvez, Carlos; Herrera Cruz, Danilo; Sanchez Rosenberg, Guillermo; Matheu, Alejandro; Monterroso Cohen, David; Paul, Marie; Charles, Angeline; Lam, Justin Chak Yiu; Yeung, Man Hon Andrew; Fok, Chi Ying Jacquelyn; Li, Ka Hin Gabriel; Lai, Anthony Chuk-Him; Cheung, Yuk Hong Eric; Wong, Hong Yee; Leung, Ka Wai; Lee, Tien Seng Bryan; Lam, Wai Him; Dao, Weihei; Kwok, Stephanie Hiu-wai; Chan, Tsz-Yan Katie; Ng, Yung Kok; Mak, T. W. C.; Liu, Qinyang; Foo, Chi Chung; Yang, James; Kumar, Basant; Bhatnagar, Ankur; Upadhyaya, Vijaid; Kumar, Sunil; Muddebihal, Uday; Dar, Wasim; Janardha, K. C.; Alexander, Philip; Aruldas, Neerav; Adella, Fidelis Jacklyn; Rulie, Anthonius Santoso; Iskandar, Ferdy; Setiawan, Jonny; Evajelista, Cicilia Viany; Natalie, Hani; Suyadi, Arlindawati; Gunawan, Rudy; Karismaningtyas, Herlin; Mata, Lusi Padma Sulistianingsih; Andika, Ferry Fitriya Ayu; Hasanah, Afifatun; Widiastini, T. Ariani; Purwaningsih, Nurlaila Ayu; Mukin, Annisa Dewi Fitriana; Rahmah, Dina Faizatur; Nurqistan, Hazmi Dwinanda; Arsyad, Hasbi Maulana; Adhitama, Novia; Jeo, Wifanto Saditya; Sutandi, Nathania; Clarissa, Audrey; Gultom, Phebe Anggita; Billy, Matthew; Haloho, Andreass; Amandito, Radhian; Johanna, Nadya; Lee, Felix; Dorani, Radin Mohd Nurrahman Radin; Glynn, Martha; Alherz, Mohammad; Goh, Wennweoi; Shiwani, Haaris A.; Sproule, Lorraine; Conlon, Kevin C.; Bala, Miklosh; Kedar, Asaf; Turati, Luca; Bianco, Federica; Steccanella, Francesca; Gallo, Gaetano; Trompetto, Mario; Clerico, Giuseppe; Papandrea, Matteo; Sammarco, Giuseppe; Sacco, Rosario; Benevento, Angelo; Pata, Francesco; Giavarini, Luisa; Giglio, Mariano Cesare; Bucci, Luigi; Pagano, Gianluca; Sollazzo, Viviana; Peltrini, Roberto; Luglio, Gaetano; Birindelli, Arianna; Di Saverio, Salomone; Tugnoli, Gregorio; Paludi, Miguel Angel; Mingrone, Pietro; Pata, Domenica; Selvaggi, Francesco; Selvaggi, Lucio; Pellino, Gianluca; Di Martino, Natale; Curletti, Gianluca; Aonzo, Paolo; Galleano, Raffaele; Berti, Stefano; Francone, Elisa; Boni, Silvia; Lorenzon, Laura; lo Conte, Annalisa; Balducci, Genoveffa; Confalonieri, Gianmaria; Pesenti, Giovanni; Gavagna, Laura; Vasquez, Giorgio; Targa, Simone; Occhionorelli, Savino; Andreotti, Dario; Pata, Giacomo; Armellini, Andrea; Chiesa, Deborah; Aquilino, Fabrizio; Chetta, Nicola; Picciariello, Arcangelo; Abdelkhalek, Mohamed; Belli, Andrea; De Franciscis, Silvia; Bigaran, Annamaria; Favero, Alessandro; Basso, Stefano M. M.; Salusso, Paola; Perino, Martina; Mochet, Sylvie; Sasia, Diego; Riente, Francesco; Migliore, Marco; Merlini, David; Basilico, Silvia; Corbellini, Carlo; Lazzari, Veronica; Macchitella, Yuri; Bonavina, Luigi; Angelieri, Daniele; Coletta, Diego; Falaschi, Federica; Catani, Marco; Reali, Claudia; Malavenda, Mariastella; Del Basso, Celeste; Ribaldi, Sergio; Coletti, Massimo; Natili, Andrea; Depalma, Norma; Iannone, Immacolata; Antoniozzi, Angelo; Rossi, Davide; Gui, Daniele; Perrotta, Gerardo; Ripa, Matteo; Giardino, Francesco Ruben; Foco, Maurizio; Vicario, Erika; Coccolini, Federico; Ansaloni, Luca; Nita, Gabriela Elisa; Leone, Nicoletta; Bondurri, Andrea; Maffioli, Anna; Simioni, Andrea; De Boni, Davide; Pasquali, Sandro; Goldin, Elena; Vendramin, Elena; Ciccioli, Eleonora; Tedeschi, Umberto; Bortolasi, Luca; Violi, Paola; Campagnaro, Tommaso; Conci, Simone; Lazzari, Giovanni; Iacono, Calogero; Gulielmi, Alfredo; Manfreda, Serena; Rinaldi, Anna; Ringressi, Maria Novella; Brunoni, Beatrice; Salamone, Giuseppe; Mangiapane, Mirko; De Marco, Paolino; La Brocca, Antonella; Tutino, Roberta; Silvestri, Vania; Licari, Leo; Fontana, Tommaso; Falco, Nicolo; Cocorullo, Gianfranco; Shalaby, Mostafa; Sileri, Pierpaolo; Arcudi, Claudio; Bsisu, Isam; Aljboor, Khaled; Abusalem, Lana; Alnusairat, Aseel; Qaissieh, Ahmad; Al-Dakka, Emad; Ababneh, Ali; Halhouli, Oday; Yusufali, Taha; Mohammed, Hussein; Lando, Justus; Parker, Robert; Ndegwa, Wairimu; Jokubauskas, Mantas; Gribauskaite, Jolanta; Venskutonis, Donatas; Kuliavas, Justas; Dulskas, Audrius; Samalavicius, Narimantas E.; Jasaitis, Kristijonas; Parseliunas, Audrius; Nevieraite, Viktorija; Montrimaite, Margarita; Slapelyte, Evelina; Dainius, Edvinas; Riauka, Romualdas; Dambrauskas, Zilvinas; Subocius, Andrejus; Venclauskas, Linas; Gulbinas, Antanas; Bradulskis, Saulius; Kasputyte, Simona; Mikuckyte, Deimante; Kiudelis, Mindaugas; Zilinskas, Justas; Jankus, Tomas; Petrikenas, Steponas; Pazuskis, Matas; Urniezius, Zigmantas; Vilcinskas, Mantas; Banaitis, Vincas Jonas; Gaizauskas, Vytautas; Grisin, Edvard; Mazrimas, Povilas; Rackauskas, Rokas; Drungilas, Mantas; Lagunavicius, Karolis; Lipnickas, Vytautas; Majauskyte, Dovile; Jotautas, Valdemaras; Abaliksta, Tomas; Uscinas, Laimonas; Simutis, Gintaras; Ladukas, Adomas; Danys, Donatas; Laugzemys, Erikas; Mikalauskas, Saulius; Poskus, Tomas; Sruogiene, Elena Zdanyte; Visinskas, Petras; Zilinskiene, Reda; Dragatas, Deividas; Burmistrovas, Andrius; Tverskis, Zygimantas; Vaicius, Arturas; Mazelyte, Ruta; Zadoroznas, Antanas; Kaselis, Nerijus; Ziubryte, Greta; Rahantasoa, Finaritra Casimir Fleur Prudence; Samison, Luc Herve; Rasoaherinomenjanahary, Fanjandrainy; Tolotra, Todisoa Emmanuella Christina; Mukuzunga, Cornelius; Msosa, Vanessa; Kwatiwani, Chimwemwe; Msiska, Nelson; Chai, Feng Yih; Asilah, Siti Mohd Desa; Syibrah, Khuzaimah Zahid; Chin, Pui Xin; Salleh, Afizah; Riswan, Nur Zulaika; Roslani, April Camilla; Chong, Hoong-Yin; Aziz, Nora Abdul; Poh, Keat-Seong; Chai, Chu-Ann; Kumar, Sandip; Taher, Mustafa Mohammed; Kosai, Nik Ritza; Aziz, Dayang Nita Abdul; Rajan, Reynu; Julaihi, Rokayah; Jethwani, Durvesh Lacthman; Yahaya, Muhammad Taqiyuddin; Abdullah, Nik Azim Nik; Mathew, Susan Wndy; Chung, Kuet Jun; Nirumal, Milaksh Kumar; Tze, R. Goh Ern; Ali, Syed Abdul Wahhab Eusoffee Wan; Gan, Yiing Yee; Ting, Jesse Ron Swire; Sii, Samuel S. Y.; Koay, Kean Leong; Tan, Yi Koon; Cheah, Alvin Ee Zhiun; Wong, Chui Yee; Mat, Tuan Nur'Azmah Tuan; Chow, Crystal Yern Nee; Har, Prisca A. L.; Der, Yishan; Tew, Yong Yong; Henry, Fitjerald; Low, Xinwei; Neo, Ya Theng; Heng, Hian Ee; Kong, Shu Ning; Gan, Cheewei; Mok, Yi Ting; Tan, Yee Wen; Palayan, Kandasami; Tata, Mahadevan Deva; Cheong, Yih Jeng; Gunaseelan, Kuhaendran; Nasir, Wan Nurul Ain Wan Mohd; Yoganathan, Pigeneswaren; Lee, Eu Xian; Saw, Jian Er; Yeang, Li Jing; Koh, Pei Ying; Lim, Shyang Yee; Teo, Shuang Yi; Grech, Nicole; Magri, Daniela; Cassar, Kristina; Mizzi, Christine; Falzon, Malcolm; Shaikh, Nihaal; Scicluna, Ruth; Zammit, Stefan; Borg, Elaine; Mizzi, Sean; Brincat, Svetlana Doris; Tembo, Thelma; Le, Vu Thanh Hien; Grima, Tara; Sammut, Keith; Carabott, Kurt; Farrugia, Alexia; Zarb, Ciskje; Navarro, Andre; Dimech, Thea; Camilleri, Georgette Marie; Bertuello, Isaac; Dalli, Jeffrey; Bonavia, Karl; Corro-Diaz, Samantha; Manriquez-Reyes, Marisol; Ramos-De la Medina, Antonio; Abdelhamid, Amina; Hrora, Abdelmalek; Benammi, Sarah; Bachri, Houda; Abbouch, Meryem; Boukhal, Khaoula; Bennai, Redouane Mammar; Belkouchi, Abdelkader; Jabal, Mohamed Sobhi; Benyaiche, Chaymae; Vermaas, Maarten; Duinhouwer, Lucia; Pastora, Javier; Wood, Greta; Soledad Merlo, Maria; Ajao, Akinlabi; Ayandipo, Omobolaji; Lawal, Taiwo; Abdurrazzaaq, Abdussemiu; Alada, Muslimat; Nasir, Abdulrasheed; Adeniran, James; Habeeb, Olufemi; Popoola, Ademola; Adeyeye, Ademola; Adebanjo, Ademola; Adesanya, Opeoluwa; Adeniyi, Adewale; Mendel, Henry; Bello, Bashir; Muktar, Umar; Osinowo, Adedapo; Olajide, Thomas Olagboyega; Oshati, Oyindamola; Ihediwa, George; Adenekan, Babajide; Nwinee, Victor; Alakaloko, Felix; Ademuyiwa, Adesoji; Elebute, Olumide; Lawal, Abdulrazzaq; Bode, Chris; Olugbemi, Mojolaoluwa; Adesina, Alaba; Faturoti, Olubukola; Odutola, Oluwatomi; Adebola, Oluwaseyi; Onuoha, Clement; Taiwo, Ogechukwu; Williams, Omolara; Balogun, Fatai; Ajai, Olalekan; Oludara, Mobolaji; Njokanma, Iloba; Osuoji, Roland; Kache, Stephen; Ajah, Jonathan; Makama, Jerry; Adamu, Ahmed; Baba, Suleiman; Aliyu, Mohammad; Aliyu, Shamsudeen; Ukwenya, Yahaya; Aliyu, Halima; Sholadoye, Tunde; Daniyan, Muhammad; Ogunsua, Oluseyi; Anyanwu, Lofty-John; Sheshe, Abdurrahaman; Mohammad, Aminu; Olori, Samson; Mshelbwala, Philip; Odeyemi, Babatunde; Samson, Garba; Timothy, Oyediran Kehinde; Samuel, Sani Ali; Ajiboye, Anthony; Adeyeye, Ademola; Amole, Isaac; Abiola, Olajide; Olaolorun, Akin; Soreide, Kjetil; Veen, Torhild; Kanani, Arezo; Styles, Kristian; Herikstad, Ragnar; Larsen, Johannes Wiik; Soreide, Jon Arne; Jensen, Elisabeth; Gran, Mads; Aahlin, Eirik Kjus; Gaarder, Tina; Monrad-Hansen, Peter Wiel; Naess, Pal Aksel; Lauzikas, Giedrius; Wiborg, Joachim; Holte, Silje; Augestad, Knut Magne; Banipal, Gurpreet Singh; Monteleone, Michela; Moe, Thomas Tetens; Schultz, Johannes Kurt; Al-taher, Taher; Hamdan, Ayah; Salman, Ayman; Saadeh, Rana; Musleh, Aseel; Jaradat, Dana; Abushamleh, Soha; Hanoun, Sakhaa; Abu Qumbos, Amjad; Hamarshi, Aseel; Taher, Ayman; Qawasmi, Israa; Qurie, Khalid; Altarayra, Marwa; Ghannam, Mohammad; Shaheen, Alaa; Herebat, Azher; Abdelhaq, Aram; Shalabi, Ahmad; Abu-toyour, Maram; Asi, Fatema; Shamasneh, Ala; Atiyeh, Anwar; Mustafa, Mousa; Zaa'treh, Rula; Dabboor, Majd; Alaloul, Enas; Baraka, Heba; Meqbil, Jehad; Al-Buhaisi, Alaa; Elshami, Mohamedraed; Afana, Samah; Jaber, Sahar; Alyacoubi, Said; Abuowda, Yousef; Idress, Tasneem; Abuqwaider, Eman; Al-saqqa, Sara; Bowabsak, Alaa; El Jamassi, Alaa; Hasanain, Doaa; Al-farram, Hadeel; Salah, Maram; Firwana, Aya; Hamdan, Marwa; Awad, Israa; Ashour, Ahmad; Al Barraw, Fayez Elian; Al-khatib, Ahmed; Al-faqawi, Maha; Fares, Mohamed; Elmashala, Amjad; Adawi, Mohammad; Adawi, Ihdaa; Khreishi, Reem; Khreishi, Rose; Ashour, Ahmad; Ghaben, Ahed; Nadeem, Najwa; Saqlain, Muhammad; Abbasy, Jibran; Alvi, Abdul Rehman; Gala, Tanzeela; Shahzad, Noman; Bhopal, Kamran Faisal; Iftikhar, Zainab; Butt, Muhammad Talha; ul Razi, Syed Asaat; Ahmed, Asdaq; Niazi, Ali Khan; Raza, Ibrahim; Baluch, Fatima; Raza, Ahmed; Bani-Sadar, Ahmad; Qureshi, Ahmad Uzair; Adil, Muhammad; Raza, Awais; Javaid, Mahnoor; Waqar, Muhammad; Khan, Maryam Ali; Arshad, Mohammad Mohsin; Amjad, Mohammadasim; Machain Vega, Gustavo Miguel; Torres Cardozo, Jorge; O'Higgins Roche, Marcelo; Pertersen Servin, Gustavo Rodolfo; Segovia Lohse, Helmut Alfredo; Paez Lopez, Larissa Ines; Melo Cardozo, Ramon Augusto; Espinoza, Fernando; Perez Rojas, Angel David; Sanchez, Diana; Sanchez Samaniego, Camila; Guevara Torres, Shalon; Canta Calua, Alexander; Razuri, Cesar; Ortiz, Nadia; Rodriguez, Xianelle; Carrasco, Nahilia; Saravia, Fridiz; Miyasato, Hector Shibao; Valcarcel-Saldana, Maria; Alejos Bermudez, Ysabel Esthefany; Carpio, Juan; Ruiz Panez, Walter; Toribio Orbegozo, Pedro Angel; Guzman Duenas, Carolina; Turpo Espinoza, Kevin; Sandoval Barrantes, Ana Maria; Chungui Bravo, Jorge Armando; Shu, Sebastian; Fuentes-Rivera, Lorena; Fernandez, Carmen; Romani, Diego; Malaga, Barbara; Ye, Joselyn; Velasquez, Ricardo; Salcedo, Jannin; Lucia Contreras-Vergara, Ana; Vergara Mejia, Angelica Genoveva; Gonzales Montejo, Maria Soledad; Escalante Salas, Marilia Del Carmen; Alcca Ticona, Willy; Vargas, Marvin; Manrique Sila, George Christian; Mas, Robinson; del Pilar Paucar, Arazzelly; Roman Velasquez, Armando Jose; Robledo-Rabanal, Alina; Zeta Solis, Ludwing Alexander; Turpo Espinoza, Kenny; Hamasaki Hamaguchi, Jose Luis; Florez Farfan, Erick Samuel; Madrid Barrientos, Linda Alvi; Herrera Matta, Juan Jaime; Mora, John Jemuel V.; Redota, Menold Archee P.; Francisco Roxas, Manuel; Mano, Maria Jesusa B.; Dione Parreno-Sacdalan, Marie; Carmela Lapitan, Marie; Leanne Almanon, Christel; Waledziak, Maciej; Roszkowski, Rafal; Janik, Michal; Lasek, Anna; Major, Piotr; Radkowiak, Dorota; Rubinkiewicz, Mateusz; Fernandes, Cristina; Costa-Maia, Jose; Melo, Renato; Muntean, Liviu; Mironescu, Aurel Sandu; Vida, Lucian Corneliu; Kourdouli, Amar; Popa, Mariuca; Mircea, Hogea; Vartic, Mihaela; Diaconescu, Bogdan; Bratu, Matei Razvan; Negoi, Ionut; Beuran, Mircea; Ciubotaru, Cezar; Ingabire, J. C. Allen; Mutabazi, Alphonse Zeta; Uzabumwana, Norbert; Jovine, Elio; Zanini, Nicola; Landolfo, Giovanni; Aljiffry, Murad; Idris, Faisal; Alghamdi, Mohammed Saleh A.; Maghrabi, Ashraf; Altaf, Abdulmalik; Alkaaki, Aroub; Khoja, Ahmad; Nawawi, Abrar; Turkustani, Sondos; Khalifah, Eyad; Gudal, Ahmad; Albiety, Adel; Sahel, Sarah; Alshareef, Reham; Najjar, Mohammed; Alzahrani, Ahmed; Alghamdi, Ahmed; Alhazmi, Wedyan; Al Saied, Ghiath; Alamoudi, Mohammed; Riaz, Muhammed Masood; Hassanain, Mazen; Alhassan, Basmah; Altamimi, Abdullah; Alyahya, Reem; Al Subaie, Norah; Al Bastawis, Fatema; Altamimi, Afnan; Nouh, Thamer; Khan, Roaa; Radojkovic, Milan; Jeremic, Ljiljana; Nestorovic, Milica; Law, Jia Hao; Tan, Keith Say Kwang; Tan, Ryan Choon Kiat; Tan, Joel Kin; Joel, Lau Wen Liang; Lieske, Bettina; Chan, Xue Wei; Leong, Faith Qi Hui; Chong, Choon Seng; Koh, Sharon; Lee, Kai Yin; Lee, Kuok Chung; Pluke, Kent; Dedekind, Britta; Nashidengo, Puyearashid; Hampton, Mark Ian; Joosten, Johanna; Sobnach, Sanju; Roodt, Liana; Sander, Anthony; Pape, James; Spence, Richard; Maistry, Niveshni; Ndwambi, Phumudzo; Kinandu, Kamau; Tun, Myint; Du Toit, Frederick; Ellison, Quinn; Burger, Sule; Grobler, D. C.; Khulu, Lawrence Bongani; Moore, Rachel; Jennings, Vicky; Leusink, Astrid; Kariem, Nazmie; Gouws, Juan; Chu, Kathryn; Bougard, Heather; Noor, Fazlin; Dell, Angela; Rayne, Sarah; Van Straten, Stephanie; Khamajeet, Arvin; Tshisola, Serge Kapenda; Kabongo, Kalangu; Kong, Victor; Moodley, Yoshan; Anderson, Frank; Madiba, Thandinkosi; du Plooy, Flip; Hartford, Leila; Chilton, Gareth; Karjiker, Parveen; Mabitsela, Matlou Ernest; Ndlovu, Sibongile Ruth; Badicel, Maria; Jaich, Robert; Ruiz-Tova, Jaime; Garcia-Florez, Luis; Otero-Diez, Jorge L.; Ramos Perez, Virginia; Aguado Suarez, Nuria; Minguez Garcia, Javier; Corral Moreno, Sara; Vicenta Collado, Maria; Jimenez Carneros, Virginia; Garcia Septiem, Javier; Gonzalez, Mariana; Picardo, Antonio; Gonzalez, Mariana; Picardo, Antonio; Esteban, Enrique; Ferrero, Esther; Ortega, Irene; Espin-Basany, Eloy; Blanco-Colino, Ruth; Andriola, Valeria; Solar Garcia, Lorena; Contreras, Elisa; Garcia Bernardo, Carmen; Pagnozz, Janet; Sanz, Sandra; Miyar de Leon, Alberto; Dorisme, Asnel; Rodicio, Joseluis; Suarez, Aida; Stuva, Jessica; Diaz Vico, Tamara; Fernandez-Vega, Laura; Soldevila-Verdeguer, Carla; Sena-Ruiz, Fatima; Pujol-Cano, Natalia; Diaz-Jover, Paula; Maria Garcia-Perez, Jose; Jose Segura-Sampedro, Juan; Pineno-Flores, Cristina; Ambrona-Zafra, David; Craus-Miguel, Andrea; Jimenez-Morillas, Patricia; Mazzella, Angela; Jayathilake, A. B.; Thalgaspitiya, S. P. B.; Wijayarathna, L. S.; Wimalge, P. M. S. N.; Sanni, Hakeem Ayomi; Ndajiwo, Aliyu; Okenabirhie, Ogheneochuko; Homeida, Anmar; Younis, Abobaker; Omer, Omer Abdelbagi; Abdulaziz, Mustafa; Mussad, Ali; Adam, Ali; Cengiz, Yucel; Bjorklund, Ida; Ahlqvist, Sandra; Ahlqvist, Sandra; Thorell, Anders; Wogensen, Fredrik; Sokratous, Arestis; Breistrand, Michaela; Thorarinsdottir, Hildur; Sigurdadottir, Johanna; Nikberg, Maziar; Chabok, Abbas; Hjertberg, Maria; Elbe, Peter; Saraste, Deborah; Rutkowski, Wiktor; Forlin, Louise; Niska, Karoliina; Sund, Malin; Oswald, Dennis; Peros, Georgios; Bluelle, Rafael; Reinisch, Katharina; Frey, Daniel; Palma, Adrian; Raptis, Dimitri Aristotle; Zumbuhl, Lucius; Zuber, Markus; Schmid, Roger; Werder, Gabriela; Nocito, Antonio; Gerosa, Alexandra; Mahanty, Silke; Widmer, Lukas Werner; Mueller, Julia; Gubeli, Alissa; Zuk, Grzegorz; Gulcicek, Osman Bilgin; Altinel, Yuksel; Vartanoglu, Talar; Kose, Emin; Karahan, Servet Rustu; Aydin, Mehmet Can; Sahbaz, Nuri Alper; Halicioglu, Ilkay; Alis, Halil; Sapci, Ipek; Adiyaman, Can; Pektas, Ahmet Murat; Cengiz, Turgut Bora; Tansoker, Ilkan; Isler, Vedatcan; Cevik, Muazzez; Mutlu, Deniz; Ozben, Volkan; Ozmen, Berk Baris; Bayram, Sefa; Yolcu, Sinem; Kobal, Berna Buse; Toto, Omer Faruk; Cakaloglu, Haluk Cem; Karabulut, Kagan; Mutlu, Vahit; Ozkan, Bahar Busra; Celik, Saban; Semiz, Anil; Bodur, Selim; Gul, Enisburak; Murutoglu, Busra; Yildirim, Reyyan; Baki, Bahadir Emre; Arslan, Ekin; Guner, Ali; Tomas, Kadir; Walker, Nathan; Shrimanker, Nikhita; Stoddart, Michael; Cole, Simon; Breslin, Ryan; Srinivasan, Ravi; Elshaer, Mohamed; Hunter, Kristina; Al-Bahrani, Ahmed; Liew, Ignatius; Mairs, Nora Grace; Rocke, Alistair; Dick, Lachlan; Qureshi, Mobeen; Chowdhury, Debkumar; Wright, Naomi; Skerritt, Clare; Kufeji, Dorothy; Ho, Adrienne; Dissanayake, Tharindra; Tennakoon, Athula; Ali, Wadah; Lim, Shujing Jane; Tan, Charlene; O'Neill, Stephen; Jones, Catrin; Knight, Stephen; Nassif, Dima; Sharma, Abhishek; Warren, Oliver; White, Rebecca; Mehdi, Aia; Post, Nathan; Kalakouti, Eliana; Dashnyam, Enkhbat; Stourton, Frederick; Mykoniatis, Ioannis; Currow, Chelise; Wong, Francisca; Gupta, Ashish; Shatkar, Veeranna; Luck, Joshua; Kadiwar, Suraj; Smedley, Alexander; Wakefield, Rebecca; Herrod, Philip; Blackwell, James; Lund, Jonathan; Cohen, Fraser; Bandi, Ashwath; Giuliani, Stefano; Bond-Smith, Giles; Pezas, Theodore; Farhangmehr, Neda; Urbonas, Tomas; Perenyei, Miklos; Ireland, Philip; Blencowe, Natalie; Bowling, Kirk; Bunting, David; Longstaff, Lydia; Smart, Neil; Keogh, Kenneth; Jeon, Hyunjin; Iqbal, Muhammad Rafaih; Khosla, Shivun; Jeffery, Anna; Perera, James; Teasdale, Ella; Ibrahem, Ahmad Aboelkassem; Alhammali, Tariq; Salama, Yahya; Kabariti, Rakan; Oram, Shaun; Kidd, Thomas; Cullen, Fraser; Owen, Christopher; Wilson, Michael; Chiu, Seehui; Sarafilovic, Hannah; Ploski, Jennifer; Evans, Elizabeth; Abbas, Athar; Kamya, Sylvia; Ishak, Norzawani; Bisset, Carly; Andress, Cedar; Chin, Ye Ru; Patel, Priya; Evans, David; Jeffery, Anna; Perera, James; Haslegrave, Aidan; Boggon, Adam; Laurie, Kirsten; Connor, Katie; Mann, Thomas; Nepogodiev, Dmitri; Mansuri, Anahita; Davies, Rachel; Griffiths, Ewen; Shahbaz, Aized Raza; Eng, Calvin; Din, Farhat; L'Heveder, Ariadne; Park, Esther H. G.; Ravishankar, Ramanish; McIntosh, Kirsten; Yau, Jih Dar; Chan, Luke; McGarvie, Susan; Tang, Lingshan; Lim, Hui; Yap, Suhhuey; Park, Jay; Ng, Zhan Herr; Mirza, Shahrukh; Ang, Yun Lin; Walls, Luke; Teasdale, Ella; Roy, Chloe; Paterson-Brown, Simon; Camilleri-Brennan, Julian; Mclean, Kenneth; D'Souza, Michelle S.; Pronin, Savva; Henshall, David Ewart; Ter, Eunice Zuling; Fouad, Dina; Minocha, Ashish; English, William; Morgan, Catrin; Townsend, Dominic; Maciejec, Laura; Mahdi, Shareef; Akpenyi, Onyinye; Hall, Elisabeth; Caydiid, Hanaan; Rob, Zakaria; Abbott, Tom; Torrance, Hew D.; Irwin, Gareth; Johnston, Robin; Gani, Mohammed Akil; Gravante, Gianpiero; Rajmohan, Shivanchan; Majid, Kiran; Dindyal, Shiva; Smith, Christopher; Palliyil, Madanmohan; Patel, Sanjay; Nicholson, Luke; Harvey, Neil; Baillie, Katie; Shillito, Sam; Kershaw, Suzanne; Bamford, Rebecca; Orton, Peter; Reunis, Elke; Tyler, Robert; Soon, Wai Cheong; Jama, Guled M.; Dhillon, Dharminder; Patel, Khyati; Nanthakumaran, Shayanthan; Heard, Rachel; Chen, Kar Yan; Barmayehvar, Behrad; Datta, Uttaran; Kamarajah, Sivesh K.; Karandikar, Sharad; Tani, Sobhana Iftekhar; Monaghan, Eimear; Donnelly, Philippa; Walker, Michael; Parakh, Jehangirshaw; Blacker, Sarah; Kaul, Anil; Paramasivan, Arjun; Farag, Sameh; Nessa, Ashrafun; Awadallah, Salwa; Lim, Jieqi; Ng, James Chean Khun; Gash, Katherine; Kiran, Ravi P.; Murray, Alice; Etchill, Eric; Dasari, Mohini; Puyana, Juan; Haddad, Nadeem; Zielinski, Martin; Choudhry, Asad; Caliman, Celeste; Beamon, Mieshia; Duane, Therese; Narayanan, Ragavan; Swaroop, Mamta; Myers, Jonathan; Deal, Rebecca; Schadde, Erik; Hemmila, Mark; Napolitano, Lena; To, Kathleen; Makupe, Alex; Musowoya, Joseph; Maimbo, Mayaba; Van Der Naald, Niels; Kumwenda, Dayson; Reece-Smith, Alex; Otten, Kars; Verbeek, Anna; Prins, Marloes; Baquero Suarez, Alibeth Andres; Balmaceda, Ruben; Deane, Chelsea; Dijan, Emilio; Elfiky, Mahmoud; Koskenvuo, Laura; Thollot, Aurore; Limoges, Bernard; Capito, Carmen; Alexandre, Challine; Kotobi, Henri; Leroux, Julien; Rod, Julien; Pinnagoda, Kalitha; Henric, Nicolas; Azzis, Olivier; Rosello, Olivier; Francois, Poddevin; Etienne, Sara; Buisson, Philippe; Hmila, Sophian; Clegg-Lamptey, Joe-Nat; Imoro, Osman; Abem, Owusu Emmanuel; Wondoh, Paul; Papageorgiou, Dimitrios; Soulou, Vasiliki; Asturias, Sabrina; Pena, Lenin; Kumar, Basant; O'Connor, Donal B.; Luc, Alberto Realis; Russo, Alfio Alessandro; Ruzzenente, Andrea; Taddei, Antonio; Cona, Camilla; Bottini, Corrado; Pascale, Giovanni; Rotunno, Giuseppe; Solaini, Leonardo; Pascale, Marco Maria; Notarnicola, Margherita; Corbellino, Mario; Sacco, Michele; Ubiali, Paolo; Cautiero, Roberto; Bocchetti, Tommaso; Muzio, Elena; Guglielmo, Vania; Morandi, Eugenio; Mao, Patrizio; De Luca, Emilia; Notarnicola, Margherita; Mahmoud, Farah; Zilinskas, Justas; Strupas, Kestutis; Kondrotas, Paulius; Baltrunas, Robertas; Kutkevicius, Juozas; Ignatavicius, Povilas; Tan, Choy Ling; Siaw, Jia Yng; Yam, Sir Young; Wilson, Ling; Aziz, Mohamed Rezal Abdul; Bondin, John; Diaz Zorrilla, Carmina; Majbar, Anass; Sale, Danjuma; Abdullahi, Lawal; Osagie, Olabisi; Faboya, Omolara; Fatuga, Adedeji; Taiwo, Agboola; Nwabuoku, Emeka; Bliksoen, Marte; Khan, Zain Ali; Coronel, Jazmin; Miranda, Cesar; Vasquez, Idelso; Helguero-Santin, Luis M.; Rickard, Jennifer; Mironescu, Aurel; Adedeji, Adesina; Alqahtani, Saleh; Rath, Max; Van Niekerk, Michael; Koto, Modise Zacharia; Matos-Puig, Roel; Israelsson, Leif; Schuetz, Tobias; Yuksek, Mahmut Arif; Mericliler, Meric; Ulusahin, Mehmet; Wolf, Bernhard; Fairfield, Cameron; Yong, Guo Liang; Whitehurst, Katharine; Wilson, Michael; Redgrave, Natalie; Musyoka, Caroluce K.; Olivier, James; Lee, Kathryn; Cox, Michael; Farhan-Alanie, Muhamed M. H.; Callan, Rory; Chibuye, Chali; Ali, Tebian Hassanein Ahmed; Rekhis, Syrine; Rommaneh, Muna; Halhouli, Oday; Sam, Zi Hao; Ismail, Lawani; Kalles, Vasileios; Pata, Francesco; Nita, Gabriela Elisa; Coccolini, Federico; Ansaloni, Luca; Pugliesi, Thays Brunelli; Pardo, Gabriel; Blanco, Ruth; Collaborative, GlobalSurg
    Background Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials. gov, number NCT02662231. Findings Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58.5\%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31.2\%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (1.2\%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12.3\%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 {[}9.4\%] of 7339 patients), middle (549 {[}14.0\%] of 3918 patients), and low (298 {[}23.2\%] of 1282) HDI (p<0.001). The highest SSI incidence in each HDI group was after dirty surgery (102 {[}17.8\%] of 574 patients in high-HDI countries
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    Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications
    (ELSEVIER SCI LTD, 2019-01-01) Cortegiani, A.; Gregoretti, C.; Neto, A. S.; Hemmes, S. N. T.; Ball, L.; Canet, J.; Hiesmayr, M.; Hollmann, M. W.; Mills, G. H.; Melo, M. F. V.; Putensen, C.; Schmid, W.; Severgnini, P.; Wrigge, H.; de Abreu, M. Gama; Schultz, M. J.; Pelosi, P.; Kroell, Wolfgang; Metzler, Helfried; Struber, Gerd; Wegscheider, Thomas; Gombotz, Hans; Hiesmayr, Michael; Schmid, Werner; Urbanek, Bernhard; Kahn, David; Momeni, Mona; Pospiech, Audrey; Lois, Fernande; Forget, Patrice; Grosu, Irina; Poelaert, Jan; van Mossevelde, Veerle; van Malderen, Marie-Claire; Dylst, Dimitri; van Melkebeek, Jeroen; Beran, Maud; de Hert, Stefan; De Baerdemaeker, Luc; Heyse, Bjorn; Van Limmen, Jurgen; Wyffels, Piet; Jacobs, Tom; Roels, Nathalie; De Bruyne, Ann; van de Velde, Stijn; Leva, Brigitte; Damster, Sandrine; Plichon, Benoit; Juros-Zovko, Marina; Djonovic-Omanovic, Dejana; Pernar, Selma; Zunic, Josip; Miskovic, Petar; Zilic, Antonio; Kvolik, Slavica; Ivic, Dubravka; Azenic-Venzera, Darija; Skiljic, Sonja; Vinkovic, Hrvoje; Oputric, Ivana; Juricic, Kazimir; Frkovic, Vedran; Kopic, Jasminka; Mirkovic, Ivan; Karanovic, Nenad; Carev, Mladen; Dropulic, Natasa; Saric, Jadranka Pavicic; Erceg, Gorjana; Dvorscak, Matea Bogdanovic; Mazul-Sunko, Branka; Pavicic, Anna Marija; Goranovic, Tanja; Maldini, Branka; Radocaj, Tomislav; Gavranovic, Zeljka; Mladic-Batinica, Inga; Sehovic, Mirna; Stourac, Petr; Harazim, Hana; Smekalova, Olga; Kosinova, Martina; Kolacek, Tomas; Hudacek, Kamil; Drab, Michal; Brujevic, Jan; Vitkova, Katerina; Jirmanova, Katerina; Volfova, Ivana; Dzurnakova, Paula; Liskova, Katarina; Dudas, Radovan; Filipsky, Radek; el Kafrawy, Samir; Abdelwahab, Hisham Hosny; Metwally, Tarek; Abdel-Razek, Ahmed; El-Shaarawy, Ahmed Mostafa; Hasan, Wael Fathy; Ahmed, Ahmed Gouda; Yassin, Hany; Magdy, Mohamed; Abdelhady, Mahdy; Mahran, Mohamed; Herodes, Eiko; Kivik, Peeter; Oganjan, Juri; Aun, Annika; Sormus, Alar; Sarapuu, Kaili; Mall, Merilin; Karjagin, Juri; Futier, Emmanuel; Petit, Antoine; Gerard, Adeline; Marret, Emmanuel; Solier, Marc; Jaber, Samir; Prades, Albert; Krassler, Jens; Merzky, Simone; Uhlig, Christopher; Kiss, Thomas; Bundy, Anette; Bluth, Thomas; Gueldner, Andreas; Spieth, Peter; Scharffenberg, Martin; Thiem, Denny Tran; Koch, Thea; Treschan, Tanja; Schaefer, Maximilian; Bastin, Bea; Geib, Johann; Weiss, Martin; Kienbaum, Peter; Pannen, Benedikt; Gottschalk, Andre; Konrad, Mirja; Westerheide, Diana; Schwerdtfeger, Ben; Wrigge, Hermann; Simon, Philipp; Reske, Andreas; Nestler, Christian; Valsamidis, Dimitrios; Stroumpoulis, Konstantinos; Antholopoulos, Georgios; Andreou, Antonis; Karapanos, Dimitris; Theodorak, Kassiani; Gkiokas, Georgios; Tasoulis, Marios-Konstantinos; Sidiropoulou, Tatiana; Zafeiropoulou, Foteini; Florou, Panagiota; Pandazi, Aggeliki; Tsaousi, Georgia; Nouris, Christos; Pourzitaki, Chryssa; Bystritski, Dmitri; Pizov, Reuven; Eden, Arieh; Pesce, Caterina Valeria; Campanile, Annamaria; Marrella, Antonella; Grasso, Salvatore; De Michele, Michele; Bona, Francesco; Giacoletto, Gianmarco; Sardo, Elena; Sottosanti, Luigi Giancarlo Vicari; Solca, Maurizio; Volta, Carlo Alberto; Spadaro, Savino; Verri, Marco; Ragazzi, Riccardo; Zoppellari, Roberto; Cinnella, Gilda; Raimondo, Pasquale; La Bella, Daniela; Mirabella, Lucia; D'antini, Davide; Molin, Alexandre; Brunetti, Iole; Gratarola, Angelo; Pellerano, Giulia; Sileo, Rosanna; Pezzatto, Stefano; Montagnani, Luca; Pasin, Laura; Landoni, Giovanni; Zangrillo, Alberto; Beretta, Luigi; Di Parma, Ambra Licia; Tarzia, Valentina; Dossi, Roberto; Sassone, Marta Eugenia; Sances, Daniele; Tredici, Stefano; Spano, Gianluca; Castellani, Gianluca; Delunas, Luigi; Peradze, Sopio; Venturino, Marco; Arpino, Ines; Sher, Sara; Tommasino, Concezione; Rapido, Francesca; Morelli, Paola; Vargas, Maria; Servillo, Giuseppe; Raineri, Santi Maurizio; Montalto, Francesca; Russotto, Vincenzo; Giarratano, Antonino; Baciarello, Marco; Generali, Michela; Cerati, Giorgia; Leykin, Yigal; Bressan, Filippo; Bartolini, Vittoria; Zamidei, Lucia; Brazzi, Luca; Liperi, Corrado; Sales, Gabriele; Pistidda, Laura; Severgnini, Paolo; Brugnoni, Elisa; Musella, Giuseppe; Bacuzzi, Alessandro; Muhardri, Dalip; Gecaj-Gashi, Agreta; Sada, Fatos; Bytyqi, Adem; Karbonskiene, Aurika; Aukstakalniene, Ruta; Teberaite, Zivile; Salciute, Erika; Tikuisis, Renatas; Miliauskas, Povilas; Jurate, Sipylaite; Kontrimaviciute, Egle; Tomkute, Gabija; Xuereb, John; Bezzina, Maureen; Borg, Francis Joseph; Hemmes, Sabrine; Schultz, Marcus; Hollmann, Markus; Wiersma, Irene; Binnekade, Jan; Bos, Lieuwe; Boer, Christa; Duvekot, Anne; in `t Veld, Bas; Werger, Alice; Dennesen, Paul; Severijns, Charlotte; De Jong, Jasper; Hering, Jens; van Beek, Rienk; Ivars, Stefan; Jammer, Ib; Breidablik, Alena; Hodt, Katharina Skirstad; Fjellanger, Frode; Avalos, Manuel Vico; Mellin-Olsen, Jannicke; Andersson, Elisabeth; Shafi-Kabiri, Amir; Molina, Ruby; Wutai, Stanley; Morais, Erick; Tareco, Gloria; Ferreira, Daniel; Amaral, Joana; Goncalves Castro, Maria de Lurdes; Cadilha, Susana; Appleton, Sofia; Parente, Suzana; Correia, Mariana; Martins, Diogo; Monteirosa, Angela; Ricardo, Ana; Rodrigues, Sara; Horhota, Lucian; Grintescu, Ioana Marina; Mirea, Liliana; Grintescu, Ioana Cristina; Corneci, Dan; Negoita, Silvius; Dutu, Madalina; Garotescu, Ioana Popescu; Filipescu, Daniela; Prodan, Alexandru Bogdan; Droc, Gabriela; Fota, Ruxandra; Popescu, Mihai; Tomescu, Dana; Petcu, Ana Maria; Tudoroiu, Marian Irinel; Moise, Alida; Guran, Catalin-Traian; Gherghina, Iorel; Costea, Dan; Cindea, Iulia; Copotoiu, Sanda-Maria; Copotoiu, Ruxandra; Barsan, Victoria; Tolcser, Zsolt; Riciu, Magda; Moldovan, Septimiu Gheorghe; Veres, Mihaly; Gritsan, Alexey; Kapkan, Tatyana; Gritsan, Galina; Korolkov, Oleg; Kulikov, Alexander; Lubnin, Andrey; Ovezov, Alexey; Prokoshev, Pavel; Lugovoy, Alexander; Anipchenko, Natalia; Babayants, Andrey; Komissarova, Irina; Zalina, Karginova; Likhvantsev, Valery; Fedorov, Sergei; Lazukic, Aleksandra; Pejakovic, Jasmina; Mihajlovic, Dunja; Kusnierikova, Zuzana; Zelinkova, Maria; Bruncakova, Katarina; Polakovicova, Lenka; Sobona, Villiam; Novak-Supe, Barbka; Pekle-Golez, Ana; Jovanov, Miroljub; Strazisar, Branka; Markovic-Bozic, Jasmina; Novak-Jankovic, Vesna; Voje, Minca; Grynyuk, Andriy; Kostadinov, Ivan; Spindler-Vesel, Alenka; Moral, Victoria; Carmen Unzueta, Mari; Puigbo, Carlos; Fava, Josep; Moret, Enrique; Rodriguez Nunez, Monica; Sendra, Mar; Brunelli, Andrea; Rodenas, Frederic; Monedero, Pablo; Hidalgo Martinez, Francisco; Yepes Temino, Maria Jose; Martinez Simon, Antonio; de Abajo Larriba, Ana; Lisi, Alberto; Perez, Gisela; Martinez, Raquel; Granell, Manuel; Tatay Vivo, Jose; Saiz Ruiz, Cristina; de Andres Ibanez, Jose Antonio; Pastor, Ernesto; Soro, Marina; Ferrando, Carlos; Defez, Mario; Aldecoa Alvares-Santullano, Cesar; Perez, Rocio; Rico, Jesus; Jawad, Monir; Saeed, Yousif; Gillberg, Lars; Bengisun, Zuleyha Kazak; Kazbek, Baturay Kansu; Coskunfirat, Nesil; Boztug, Neval; Sanli, Suat; Yilmaz, Murat; Hadimioglu, Necmiye; Senturk, Nuzhet Mert; Camci, Emre; Kucukgoncu, Semra; Sungur, Zerrin; Sivrikoz, Nukhet; Ozgen, Serpil Ustalar; Toraman, Fevzi; Selvi, Onur; Senturk, Ozgur; Yildiz, Mine; Kuvaki, Bahar; Gunenc, Ferim; Kucukguclu, Semih; Ozbilgin, Sule; Maral, Jale; Canli, Seyda; Arun, Oguzhan; Saltali, Ali; Aydogan, Eyup; Akgun, Fatma Nur; Sanlikarip, Ceren; Karaman, Fatma Mine; Mazur, Andriy; Vorotyntsev, Sergiy; Rousseau, Guy; Barrett, Colin; Stancombe, Lucia; Shelley, Ben; Scholes, Helen; Limb, James; Rafi, Amir; Wayman, Lisa; Deane, Jill; Rogerson, David; Williams, John; Yates, Susan; Rogers, Elaine; Pulletz, Mark; Moreton, Sarah; Jones, Stephanie; Venkatesh, Suresh; Burton, Maudrian; Brown, Lucy; Goodall, Cait; Rucklidge, Matthew; Fuller, Debbie; Nadolski, Maria; Kusre, Sandeep; Lundberg, Michael; Everett, Lynn; Nutt, Helen; Zuleika, Maka; Carvalho, Peter; Clements, Deborah; Creagh-Brown, Ben; Watt, Philip; Raymode, Parizade; Pearse, Rupert; Mohr, Otto; Raj, Ashok; Creary, Thais; Chishti, Ahmed; Bell, Andrea; Higham, Charley; Cain, Alistair; Gibb, Sarah; Mowat, Stephen; Franklin, Danielle; West, Claire; Minto, Gary; Boyd, Nicholas; Mills, Gary; Calton, Emily; Walker, Rachel; Mackenzie, Felicity; Ellison, Branwen; Roberts, Helen; Chikungwa, Moses; Jackson, Clare; Donovan, Andrew; Foot, Jayne; Homan, Elizabeth; Montgomery, Jane; Portch, David; Mercer, Pauline; Palmer, Janet; Paddle, Jonathan; Fouracres, Anna; Datson, Amanda; Andrew, Alyson; Welch, Leanne; Rose, Alastair; Varma, Sandeep; Simeson, Karen; Rambhatla, Mrutyunjaya; Susarla, Jaysimha; Marri, Sudhakar; Kodaganallur, Krishnan; Das, Ashok; Algarsamy, Shivarajan; Colley, Julie; Davies, Simon; Szewczyk, Margaret; Smith, Thomas; Fernandez-Bustamante, Ana; Luzier, Elizabeth; Almagro, Angela; Melo, Marcos Vidal; Fernando, Luiz; Sulemanji, Demet; Sprung, Juraj; Weingarten, Toby; Kor, Daryl; Scavonetto, Federica; Tze, Yeo; Investigators, L.A.S. V. E. G. A. S.; Network, P. R. O. V. E.; Anaesthesiology, European Soc
    Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs). Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during `daytime' when induction of anaesthesia was between 8: 00 AM and 7: 59 PM, and as `night-time' when induction was between 8: 00 PM and 7: 59 AM. Results: Of 9861 included patients, 555 (5.6\%) underwent surgery during night-time. The proportion of patients who developed intraoperative AEs was higher during night-time surgery in unmatched (43.6\% vs 34.1\%
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    Autoantibodies neutralizing type I IFNs are present in similar to 4\% of uninfected individuals over 70 years old and account for similar to 20\% of COVID-19 deaths
    (AMER ASSOC ADVANCEMENT SCIENCE, 2021-01-01) Bastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jeremie; Philippot, Quentin; Manry, Jeremy; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martinez, Alba; Yang, Rui; Haljasmagi, Liis; Migaud, Melanie; Sarekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garcon, Pierre; Riviere, Jacques G.; Lagier, Jean-Christophe; Gentile, Stephanie; Rosen, Lindsey B.; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Megarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James R.; Franco, Jose Luis; Anaya, Juan-Manuel; Sole-Violan, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia M.; Zhang, Yu; Snow, Andrew L.; Holland, Steven M.; Biggs, Catherine M.; Moncada-Velez, Marcela; Arias, Andres Augusto; Lorenzo, Lazaro; Boucherit, Soraya; Coulibaly, Boubacar; Anglicheau, Dany; Planas, Anna M.; Haerynck, Filomeen; Duvlis, Sotirija; Nussbaum, Robert L.; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Ahmed A.; El Bakkouri, Jalila; Ramirez-Santana, Carolina; Paul, Stephane; Pan-Hammarstrom, Qiang; Hammarstrom, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine N.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila A.; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; van de Beek, Diederik; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart G.; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli Y.; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis Felipe; Chauvineau-Grenier, Angelique; Venet, Fabienne; Monneret, Guillaume; Nussenzweig, Michel C.; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam H.; Kennelly, Sean P.; Bourke, Nollaig M.; Halwani, Rabih; Sharif-Askari, Narjes Saheb; Dorgham, Karim; Sallette, Jerome; Sedkaoui, Souad Mehlal; AlKhater, Suzan; Rigo-Bonnin, Raul; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald C.; Ostrowski, Sisse Rye; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, Andras N.; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard P.; Mane, Shrikant; Anderson, Mark S.; Boisson, Bertrand; Beziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Part; Mogensen, Trine H.; Rowen, Lee; Mond, James; Debette, Stephanie; de Lamballerie, Xavier; Duval, Xavier; Mentre, France; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter K.; Piemonti, Lorenzo; Rodriguez-Gallego, Carlos; Notarangelo, Luigi D.; Su, Helen C.; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles M.; Tiberghien, Pierre; Zhang, Qian; Cobat, Aurelie; Abel, Laurent; Casanova, Jean-Laurent; Lab, H. G. I. D.; Clinicians, C. O. V. I. D.; Clinicians, C. O. V. I. D.-S. T. O. R. M.; Grp, N.I.A.I.D. Immune Response Covid; Grp, N. H.-C.O.V.A.I.R. Study; Danish, C. H. G. E.; Study, Danish Blood Donor; Interest, St Jamess Hosp Sars CoV2; Grp, French C.O.V.I.D. Cohort Study; COVID-Grp, Imagine; Consortium, Milieu Interieur; Cohort, CoV-Contact; Inv, Amsterdam Umc Covid-19 Biobank; Efft, C.O.V.I.D. Human Genetic; Cohort, C. O. N. S. T. A. N. C. E. S.; Study, 3C.-Dijon; HealthCare, Cerba; Grp, Etab Sang Study
    Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml
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    Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019
    (ELSEVIER, 2020-01-01) Gillessena, Silke; Attard, Gerhardt; Beer, Tomasz M.; Beltran, Himisha; Bjartell, Anders; Bossi, Alberto; Briganti, Alberto; Bristow, Rob G.; Chi, Kim N.; Clarke, Noel; Davis, Ian D.; de Bono, Johann; Drake, Charles G.; Duran, Ignacio; Eeles, Ros; Efstathiou, Eleni; Evans, Christopher P.; Fanti, Stefano; Feng, Felix Y.; Fizazi, Karim; Frydenberg, Mark; Gleave, Martin; Halabi, Susan; Heidenreich, Axel; Heinrich, Daniel; Higano, Celestia (Tia) S.; Hofman, Michael S.; Hussain, Maha; James, Nicolas; Kanesvaran, Ravindran; Kantoff, Philip; Khauli, Raja B.; Leibowitz, Raya; Logothetis, Chris; Maluf, Fernando; Millman, Robin; Morgans, Alicia K.; Morris, Michael J.; Mottet, Nicolas; Mrabti, Hind; Murphy, Declan G.; Murthy, Vedang; Oh, William K.; Ost, Piet; OSullivan, Joe M.; Padhani, Anwar R.; Parker, Chris; Poon, Darren M. C.; Pritchard, Colin C.; Reiter, Robert E.; Roach, Mack; Rubin, Mark; Ryan, Charles J.; Saad, Fred; Sade, Juan Pablo; Sartor, Oliver; Scher I, Howard; Shore, Neal; Small, Eric; Smith, Matthew; Soule, Howard; Sternberg, Cora N.; Steuber, Thomas; Suzuki, Hiroyoshi; Sweeneyh, Christopher; Sydes, Matthew R.; Taplinh, Mary-Ellen; Tombal, Bertrand; Turkeri, Levent; van Oort, Inge; Zapatero, Almudena; Omlind, Aurelius
    Background: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but there are still many aspects of management that lack high-level evidence to inform clinical practice. The Advanced Prostate Cancer Consensus Conference (APCCC) 2019 addressed some of these topics to supplement guidelines that are based on level 1 evidence. Objective: To present the results from the APCCC 2019. Design, setting, and participants: Similar to prior conferences, experts identified 10 important areas of controversy regarding the management of advanced prostate cancer: locally advanced disease, biochemical recurrence after local therapy, treating the primary tumour in the metastatic setting, metastatic hormone-sensitive/naive prostate cancer, nonmetastatic castration-resistant prostate cancer, metastatic castration-resistant prostate cancer, bone health and bone metastases, molecular characterisation of tissue and blood, inter- and intrapatient heterogeneity, and adverse effects of hormonal therapy and their management. A panel of 72 international prostate cancer experts developed the programme and the consensus questions. Outcome measurements and statistical analysis: The panel voted publicly but anonymously on 123 predefined questions, which were developed by both voting and nonvoting panel members prior to the conference following a modified Delphi process. Results and limitations: Panellists voted based on their opinions rather than a standard literature review or formal meta-analysis. The answer options for the consensus questions had varying degrees of support by the panel, as reflected in this article and the detailed voting results reported in the Supplementary material. Conclusions: These voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019 once again identified important questions that merit assessment in specifically designed trials. Patient summary: The Advanced Prostate Cancer Consensus Conference provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference, which has been held three times since 2015, aims to share the knowledge of world experts in prostate cancer management with health care providers worldwide. At the end of the conference, an expert panel discusses and votes on predefined consensus questions that target the most clinically relevant areas of advanced prostate cancer treatment. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients as part of shared and multidisciplinary decision making. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.
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    The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome (vol 21, pg 1295, 2019)
    (NATURE PUBLISHING GROUP, 2019-01-01) van der Sluijs, Pleuntje J.; Jansen, Sandra; Vergano, Samantha A.; Adachi-Fukuda, Miho; Alanay, Yasemin; AlKindy, Adila; Baban, Anwar; Bayat, Allan; Beck-Woedl, Stefanie; Berry, Katherine; Bijlsma, Emilia K.; Bok, Levinus A.; Brouwer, Alwin F. J.; van der Burgt, Ineke; Campeau, Philippe M.; Canham, Natalie; Chrzanowska, Krystyna; Chu, Yoyo W. Y.; Chung, Brain H. Y.; Dahan, Karin; De Rademaeker, Marjan; Destree, Anne; Dudding-Byth, Tracy; Earl, Rachel; Elcioglu, Nursel; Elias, Ellen R.; Fagerberg, Christina; Gardham, Alice; Gener, Blanca; Gerkes, Erica H.; Grasshoff, Ute; van Haeringen, Arie; Heitink, Karin R.; Herkert, Johanna C.; den Hollander, Nicolette S.; Horn, Denise; Hunt, David; Kant, Sarina G.; Kato, Mitsuhiro; Kayserili, Hulya; Kersseboom, Rogier; Kilic, Esra; Krajewska-Walasek, Malgorzata; Lammers, Kylin; Laulund, Lone W.; Lederer, Damien; Lees, Melissa; Lopez-Gonzalez, Vanesa; Maas, Saskia; Mancini, Grazia M. S.; Marcelis, Carlo; Martinez, Francisco; Maystadt, Isabelle; McGuire, Marianne; Mckee, Shane; Mehta, Sarju; Metcalfe, Kay; Milunsky, Jeff; Mizuno, Seiji; Moeschler, John B.; Netzer, Christian; Ockeloen, Charlotte W.; Oehl-Jaschkowitz, Barbara; Okamoto, Nobuhiko; Olminkhof, Sharon N. M.; Orellana, Carmen; Pasquier, Laurent; Pottinger, Caroline; Riehmer, Vera; Robertson, Stephen P.; Roifman, Maian; Rooryck, Caroline; Ropers, Fabienne G.; Rosello, Monica; Ruivenkamp, Claudia A. L.; Sagiroglu, Mahmut S.; Sallevelt, Suzanne C. E. H.; Calvo, Amparo Sanchis; Simsek-Kiper, Pelin O.; Soares, Gabriela; Solaeche, Lucia; Sonmez, Fatma Mujgan; Splitt, Miranda; Steenbeek, Duco; Stegmann, Alexander P. A.; Stumpel, Constance T. R. M.; Tanabe, Saori; Uctepe, Eyyup; Utine, G. Eda; Veenstra-Knol, Hermine E.; Venkateswaran, Sunita; Vilain, Catheline; Vincent-Delorme, Catherine; Vulto-van Silfhout, Anneke T.; Wheeler, Patricia; Wilson, Golder N.; Wilson, Louise C.; Wollnik, Bernd; Kosho, Tomoki; Wieczorek, Dagmar; Eichler, Evan; Pfundt, Rolph; de Vries, Bert B. A.; Clayton-Smith, Jill; Santen, Gijs W. E.
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    The ARID1B spectrum in 143 patients: from nonsyndromic intellectual disability to Coffin-Siris syndrome
    (SPRINGERNATURE, 2019-01-01) van der Sluijs, Pleuntje J.; Jansen, Sandra; Vergano, Samantha A.; Adachi-Fukuda, Miho; Alanay, Yasemin; AlKindy, Adila; Baban, Anwar; Bayat, Allan; Beck-Woedl, Stefanie; Berry, Katherine; Bijlsma, Emilia K.; Bok, Levinus A.; Brouwer, Alwin F. J.; van der Burgt, Ineke; Campeau, Philippe M.; Canham, Natalie; Chrzanowska, Krystyna; Chu, Yoyo W. Y.; Chung, Brain H. Y.; Dahan, Karin; De Rademaeker, Marjan; Destree, Anne; Dudding-Byth, Tracy; Earl, Rachel; Elcioglu, Nursel; Elias, Ellen R.; Fagerberg, Christina; Gardham, Alice; Gener, Blanca; Gerkes, Erica H.; Grasshoff, Ute; van Haeringen, Arie; Heitink, Karin R.; Herkert, Johanna C.; den Hollander, Nicolette S.; Horn, Denise; Hunt, David; Kant, Sarina G.; Kato, Mitsuhiro; Kayserili, Hulya; Kersseboom, Rogier; Kilic, Esra; Krajewska-Walasek, Malgorzata; Lammers, Kylin; Laulund, Lone W.; Lederer, Damien; Lees, Melissa; Lopez-Gonzalez, Vanesa; Maas, Saskia; Mancini, Grazia M. S.; Marcelis, Carlo; Martinez, Francisco; Maystadt, Isabelle; McGuire, Marianne; McKee, Shane; Mehta, Sarju; Metcalfe, Kay; Milunsky, Jeff; Mizuno, Seiji; Moeschler, John B.; Netzer, Christian; Ockeloen, Charlotte W.; Oehl-Jaschkowitz, Barbara; Okamoto, Nobuhiko; Olminkhof, Sharon N. M.; Orellana, Carmen; Pasquier, Laurent; Pottinger, Caroline; Riehmer, Vera; Robertson, Stephen P.; Roifman, Maian; Rooryck, Caroline; Ropers, Fabienne G.; Rosello, Monica; Ruivenkamp, Claudia A. L.; Sagiroglu, Mahmut S.; Sallevelt, Suzanne C. E. H.; Sanchis Calvo, Amparo; Simsek-Kiper, Pelin O.; Soares, Gabriela; Solaeche, Lucia; Sonmez, Fatma Mujgan; Splitt, Miranda; Steenbeek, Duco; Stegmann, Alexander P. A.; Stumpel, Constance T. R. M.; Tanabe, Saori; Uctepe, Eyyup; Utine, G. Eda; Veenstra-Knol, Hermine E.; Venkateswaran, Sunita; Vilain, Catheline; Vincent-Delorme, Catherine; Vulto-van Silfhout, Anneke T.; Wheeler, Patricia; Wilson, Golder N.; Wilson, Louise C.; Wollnik, Bernd; Kosho, Tomoki; Wieczorek, Dagmar; Eichler, Evan; Pfundt, Rolph; de Vries, Bert B. A.; Clayton-Smith, Jill; Santen, Gijs W. E.
    Purpose: Pathogenic variants in ARID1B are one of the most frequent causes of intellectual disability (ID) as determined by large-scale exome sequencing studies. Most studies published thus far describe clinically diagnosed Coffin-Siris patients (ARID1BCSS) and it is unclear whether these data are representative for patients identified through sequencing of unbiased ID cohorts (ARID1B-ID). We therefore sought to determine genotypic and phenotypic differences between ARID1B-ID and ARID1B-CSS. In parallel, we investigated the effect of different methods of phenotype reporting. Methods: Clinicians entered clinical data in an extensive webbased survey. Results: 79 ARID1B-CSS and 64 ARID1B-ID patients were included. CSS-associated dysmorphic features, such as thick eyebrows, long eyelashes, thick alae nasi, long and/or broad philtrum, small nails and small or absent fifth distal phalanx and hypertrichosis, were observed significantly more often (p < 0.001) in ARID1B-CSS patients. No other significant differences were identified. Conclusion: There are only minor differences between ARID1BID and ARID1B-CSS patients. ARID1B-related disorders seem to consist of a spectrum, and patients should be managed similarly. We demonstrated that data collection methods without an explicit option to report the absence of a feature (such as most Human Phenotype Ontology-based methods) tended to underestimate gene-related features.
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    Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society
    (PUBLIC LIBRARY SCIENCE, 2019-01-01) Koc, Esin; Demirel, Nihal; Bas, Ahmet Yagmur; Isik, Dilek Ulubas; Hirfanoglu, Ibrahim Murat; Tunc, Turan; Sari, Fatma Nur; Karatekin, Guner; Ozdemir, Ramazan; Altunhan, Huseyin; Cetinkaya, Merih; Ozcan, Beyza; Ozkiraz, Servet; Calkavur, Sebnem; Tekgunduz, Kadir Serafettin; Tastekin, Ayhan; Ozlu, Ferda; Ozyurt, Banu Mutlu; Ozdemir, Ahmet; Cetinkaya, Bilin; Demirelli, Yasar; Koklu, Esad; Celik, Ulker; Tarakci, Nuriye; Armangil, Didem; Okulu, Emel; Narter, Fatma; Mutlu, Birgul; Mert, Mustafa Kurthan; Bulbul, Ali; Asker, Huseyin Selim; Uygur, Ozgun; Uslu, Ilker Sait; Ertugrul, Sabahattin; Aydemir, Cumhur; Celik, Hasan Tolga; Kucuktasci, Kazim; Arslan, Selda; Ergin, Hacer; Zenciroglu, Aysegul; Yurttutan, Sadik; Orman, Aysen; Tuncer, Oguz; Yasa, Beril; Acunas, Betul; Takci, Sahin; Gokmen, Zeynel; Ozkan, Hilal; Comert, Serdar; Ustun, Nuran; Mutlu, Mehmet; Bayraktar, Bilge Tanyeri; Bilgin, Leyla; Tuzun, Funda; Aydemir, Ozge; Gursoy, Tugba; Akdag, Arzu; Memisoglu, Asli; Can, Emrah; Terek, Demet; Beken, Serdar; Turan, Ozden; Guzoglu, Nilufer; Ors, Rahmi; Kale, Yusuf; Hekimoglu, Berna; Aylanc, Hakan; Eroglu, Funda; Sahin, Suzan; Konak, Murat; Sarici, Dilek; Kilic, Ilknur; Hakan, Nilay
    Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of.1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137 +/- 245 g and 29 +/- 2.4 weeks, respectively. During the study period, 78\% of VLBW infants survived to discharge and 48\% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7\% of infants, necrotizing enterocolitis in 9.1\%, blood culture proven late-onset sepsis (LOS) in 21.1\%, blood culture negative LOS in 21.3\%, severe intraventricular hemorrhage in 5.4\% and severe retinopathy of prematurity in 11.1\%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8\% of infants. Antenatal steroids were administered to 42.9\% of mothers. Conclusion The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs.
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    Defining the clinical, molecular and imaging spectrum of adaptor protein complex 4-associated hereditary spastic paraplegia
    (OXFORD UNIV PRESS, 2020-01-01) Ebrahimi-Fakhari, Darius; Teinert, Julian; Behne, Robert; Wimmer, Miriam; D'Amore, Angelica; Eberhardt, Kathrin; Brechmann, Barbara; Ziegler, Marvin; Jensen, Dana M.; Nagabhyrava, Premsai; Geisel, Gregory; Carmody, Erin; Shamshad, Uzma; Dies, Kira A.; Yuskaitis, Christopher J.; Salussolia, Catherine L.; Ebrahimi-Fakhari, Daniel; Pearson, Toni S.; Saffari, Afshin; Ziegler, Andreas; Koelker, Stefan; Volkmann, Jens; Wiesener, Antje; Bearden, David R.; Lakhani, Shenela; Segal, Devorah; Udwadia-Hegde, Anaita; Martinuzzi, Andrea; Hirst, Jennifer; Perlman, Seth; Takiyama, Yoshihisa; Xiromerisiou, Georgia; Vill, Katharina; Walker, William O.; Shukla, Anju; Gupta, Rachana Dubey; Dahl, Niklas; Aksoy, Ayse; Verhelst, Helene; Delgado, Mauricio R.; Pourova, Radka Kremlikova; Sadek, Abdelrahim A.; Elkhateeb, Nour M.; Blumkin, Lubov; Brea-Fernandez, Alejandro J.; Dacruz-Alvarez, David; Smol, Thomas; Ghoumid, Jamal; Miguel, Diego; Heine, Constanze; Schlump, Jan-Ulrich; Langen, Hendrik; Baets, Jonathan; Bulk, Saskia; Darvish, Hossein; Bakhtiari, Somayeh; Kruer, Michael C.; Lim-Melia, Elizabeth; Aydinli, Nur; Alanay, Yasemin; El-Rashidy, Omnia; Nampoothiri, Sheela; Patel, Chirag; Beetz, Christian; Bauer, Peter; Yoon, Grace; Guillot, Mireille; Miller, Steven P.; Bourinaris, Thomas; Houlden, Henry; Robelin, Laura; Anheim, Mathieu; Alamri, Abdullah S.; Mahmoud, Adel A. H.; Inaloo, Soroor; Habibzadeh, Parham; Faghihi, Mohammad Ali; Jansen, Anna C.; Brock, Stefanie; Roubertie, Agathe; Darras, Basil T.; Agrawal, Pankaj B.; Santorelli, Filippo M.; Gleeson, Joseph; Zaki, Maha S.; Sheikh I, Sarah; Bennett, James T.; Sahin, Mustafa
    Bi-allelic loss-of-function variants in genes that encode subunits of the adaptor protein complex 4 (AP-4) lead to prototypical yet poorly understood forms of childhood-onset and complex hereditary spastic paraplegia: SPG47 (AP4B1), SPG50 (AP4M1), SPG51 (AP4E1) and SPG52 (AP4S1). Here, we report a detailed cross-sectional analysis of clinical, imaging and molecular data of 156 patients from 101 families. Enrolled patients were of diverse ethnic backgrounds and covered a wide age range (1.0-49.3 years). While the mean age at symptom onset was 0.8 +/- 0.6 years {[}standard deviation (SD), range 0.2-5.0], the mean age at diagnosis was 10.2 +/- 8.5 years (SD, range 0.1-46.3). We define a set of core features: early-onset developmental delay with delayed motor milestones and significant speech delay (50\% non-verbal)
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    A global metagenomic map of urban microbiomes and antimicrobial resistance
    (CELL PRESS, 2021-01-01) Danko, David; Bezdan, Daniela; Afshin, Evan E.; Ahsanuddin, Sofia; Bhattacharya, Chandrima; Butler, Daniel J.; Chng, Kern Rei; Donnellan, Daisy; Hecht, Jochen; Jackson, Katelyn; Kuchin, Katerina; Karasikov, Mikhail; Lyons, Abigail; Mak, Lauren; Meleshko, Dmitry; Mustafa, Harun; Mutai, Beth; Neches, Russell Y.; Ng, Amanda; Nikolayeva, Olga; Nikolayeva, Tatyana; Png, Eileen; Ryon, Krista A.; Sanchez, Jorge L.; Shaaban, Heba; Sierra, Maria A.; Thomas, Dominique; Young, Ben; Abudayyeh, Omar O.; Alicea, Josue; Bhattacharyya, Malay; Blekhman, Ran; Castro-Nallar, Eduardo; Canas, Ana M.; Chatziefthimiou, Aspassia D.; Crawford, Robert W.; De Filippis, Francesca; Deng, Youping; Desnues, Christelle; Dias-Neto, Emmanuel; Dybwad, Marius; Elhaik, Eran; Ercolini, Danilo; Frolova, Alina; Gankin, Dennis; Gootenberg, Jonathan S.; Graf, Alexandra B.; Green, David C.; Hajirasouliha, Iman; Hastings, Jaden J. A.; Hernandez, Mark; Iraola, Gregorio; Jang, Soojin; Kahles, Andre; Kelly, Frank J.; Knights, Kaymisha; Kyrpides, Nikos C.; Labaj, Pawel P.; Lee, Patrick K. H.; Leung, Marcus H. Y.; Ljungdahl, Per O.; Mason-Buck, Gabriella; McGrath, Ken; Meydan, Cem; Mongodin, Emmanuel F.; Moraes, Milton Ozorio; Nagarajan, Niranjan; Nieto-Caballero, Marina; Noushmehr, Houtan; Oliveira, Manuela; Ossowski, Stephan; Osuolale, Olayinka O.; Ozcan, Orhan; Paez-Espino, David; Rascovan, Nicolas; Richard, Hugues; Ratsch, Gunnar; Schriml, Lynn M.; Semmler, Torsten; Sezerman, Osman U.; Shi, Leming; Shi, Tieliu; Siam, Rania; Song, Le Huu; Suzuki, Haruo; Court, Denise Syndercombe; Tighe, Scott W.; Tong, Xinzhao; Udekwu I, Klas; Ugalde, Juan A.; Valentine, Brandon; Vassilev I, Dimitar; Vayndorf, Elena M.; Velavan, Thirumalaisamy P.; Wu, Jun; Zambrano, Maria M.; Zhu, Jifeng; Zhu, Sibo; Mason, Christopher E.; Consortium, Int MetaSU. B.
    We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97\% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
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    Rare coding variants in genes encoding GABA(A) receptors in genetic generalised epilepsies: an exome-based case-control study
    (ELSEVIER SCIENCE INC, 2018-01-01) May, Patrick; Girard, Simon; Harrer, Merle; Bobbili, Dheeraj R.; Schubert, Julian; Wolking, Stefan; Becker, Felicitas; Lachance-Touchette, Pamela; Meloche, Caroline; Gravel, Micheline; Niturad, Cristina E.; Knaus, Julia; De Kovel, Carolien; Toliat, Mohamad; Polvi, Anne; Iacomino, Michele; Guerrero-Lopez, Rosa; Baulac, Stephanie; Marini, Carla; Thiele, Holger; Altmueller, Janine; Jabbari, Kamel; Ruppert, Ann-Kathrin; Jurkowski, Wiktor; Lal, Dennis; Rusconi, Raffaella; Cestele, Sandrine; Terragni, Benedetta; Coombs, Ian D.; Reid, Christopher A.; Striano, Pasquale; Caglayan, Hande; Siren, Auli; Everett, Kate; Moller, Rikke S.; Hjalgrim, Helle; Muhle, Hiltrud; Helbig, Ingo; Kunz, Wolfram S.; Weber, Yvonne G.; Weckhuysen, Sarah; De Jonghe, Peter; Sisodiya, Sanjay M.; Nabbout, Rima; Franceschetti, Silvana; Coppola, Antonietta; Vari, Maria S.; Trenite, Dorothee Kasteleijn-Nolst; Baykan, Betul; Ozbek, Ugur; Bebek, Nerses; Klein, Karl M.; Rosenow, Felix; Nguyen, Dang K.; Dubeau, Francois; Carmant, Lionel; Lortie, Anne; Desbiens, Richard; Clement, Jean-Francois; Cieuta-Walti, Cecile; Sills, Graeme J.; Auce, Pauls; Francis, Ben; Johnson, Michael R.; Marson, Anthony G.; Berghuis, Bianca; Sander, Josemir W.; Avbersek, Andreja; McCormack, Mark; Cavalleri, Gianpiero L.; Delanty, Norman; Depondt, Chantal; Krenn, Martin; Zimprich, Fritz; Peter, Sarah; Nikanorova, Marina; Kraaij, Robert; van Rooij, Jeroen; Balling, Rudi; Ikram, M. Arfan; Uitterlinden, Andre G.; Avanzini, Giuliano; Schorge, Stephanie; Petrou, Steven; Mantegazza, Massimo; Sander, Thomas; LeGuern, Eric; Serratosa, Jose M.; Koeleman, Bobby P. C.; Palotie, Aarno; Lehesjoki, Anna-Elina; Nothnagel, Michael; Nuernberg, Peter; Maljevic, Snezana; Zara, Federico; Cossette, Patrick; Krause, Roland; Lerche, Holger; Consortium, Epicure; Consortium, EuroEP.I.N.O.M.I.C.S. C. O. G. I. E.; Consortium, EpiPG. X.
    Background Genetic generalised epilepsy is the most common type of inherited epilepsy. Despite a high concordance rate of 80\% in monozygotic twins, the genetic background is still poorly understood. We aimed to investigate the burden of rare genetic variants in genetic generalised epilepsy. Methods For this exome-based case-control study, we used three different genetic generalised epilepsy case cohorts and three independent control cohorts, all of European descent. Cases included in the study were clinically evaluated for genetic generalised epilepsy. Whole-exome sequencing was done for the discovery case cohort, a validation case cohort, and two independent control cohorts. The replication case cohort underwent targeted next-generation sequencing of the 19 known genes encoding subunits of GABA(A) receptors and was compared to the respective GABA(A) receptor variants of a third independent control cohort. Functional investigations were done with automated two-microelectrode voltage clamping in Xenopus laevis oocytes. Findings Statistical comparison of 152 familial index cases with genetic generalised epilepsy in the discovery cohort to 549 ethnically matched controls suggested an enrichment of rare missense (Nonsyn) variants in the ensemble of 19 genes encoding GABA(A) receptors in cases (odds ratio {[}OR] 2.40 {[}95\% CI 1.41-4.10]