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    COMPARISON OF SLEEP MACRO- AND MICROSTRUCTURES IN ELDERLY AND MIDDLE-AGED MALE PATIENTS WITH SEVERE OBSTRUCTIVE SLEEP APNEA: DOES THE DISEASE ERASE DIFFERENCES?
    (GUNES KITABEVI LTD STI, 2020-01-01) Huseyinoglu, Nergiz; Kose Ozlece, Hatice; Ardic, Sadik
    Introduction: Age-related changes in sleep attract increased attention from researchers and are studied in the context of micro- and macrostructures. Macrostructures include sleep onset, total sleep time, sleep efficiency, wake time after sleep onset, and non-rapid eye movement and rapid eye movement sleep percentages, latencies and durations. Sleep microstructures refer to a cyclic alternating pattern.The present study aims to investigate how sleep structures in older and middle-aged patients are affected by the widespread disease of obstructive sleep apnea. The authors believe that it provide additional information about sleep disorder pathogenesis. Materials and Method: Patients who received a diagnosis of severe sleep apnea were divided into two groups: age >= 65 years old and 35-45 years old. Macro-and microstructural data from polysomnographic investigations were collected and compared. Results: There were no statistically significant differences for total sleep time, sleep efficiency, wake time after sleep onset, rapid eye movement sleep latency and separate percentages of non-rapid eye movement sleep stages N1, N2 and N3. Regarding sleep microstructures, there were no differences between arousal index, cyclic alternating pattern rates, or percentage ratio of phase subtype. Conclusion: The parameters of the macro- and microstructures in the older group are similar to those of the middle-aged group and are also basically similar to the parameters of previous studies