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    Biological variation and reference change value data for serum copper, zinc and selenium in Turkish adult population
    (WALTER DE GRUYTER GMBH, 2021-01-01) Bal, Ceylan; Erdogan, Serpil; Gok, Gamze; Nural, Cemil; Ozbek, Betul; Ercan, Mujgan; Serdar, Muhittin; Erel, Ozcan
    Objectives: Calculation of biological variation (BV) components is very important in evaluating whether a test result is clinically significant. The aim of this study is to analyze BV components for copper, zinc and selenium in a cohort of healthy Turkish participants. Methods: A total of 10 serum samples were collected from each of the 15 healthy individuals (nine female, six male), once a week, during 10 weeks. Copper, zinc and selenium levels were analyzed by atomic absorption spectrometer. BV parameters were calculated with the approach suggested by Fraser. Results: Analytical variation (CVA), within-subject BV (CVI), between-subject BV (CVG) values were 8.4, 7.1 and 4.3 for copper