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Item DETERMINATION OF LOWER EXTREMITY PERIPHERAL ARTERY DISEASE IN PATIENTS UNDERGOING CAROTID ENDARTERECTOMY(ISTANBUL UNIV, FAC MEDICINE, PUBL OFF, 2020-01-01) Onalan, Mehmet Akif; Bahseliyev, Siraslan; Beyaz, Metin Onur; Oztas, Didem Melis; Onal, Yilmaz; Ugurlucan, Murat; Tireli, EminObjective: Atherosclerotic vascular disease is a systemic pathology. The aim of our study was to determine the frequency of lower extremity peripheral artery disease (PAD) in patients who underwent carotid endarterectomy (CEA) and to identify risk factors. Material and Method: The study included 65 patients who underwent carotid endarterectomy in Istanbul Medical Faculty, Department of Cardiovascular Surgery between January 2011 and January 2015. The medical history, physical examination, ankle brachial index and lower extremity duplex ultrasonography results were evaluated and the patients were examined for peripheral artery disease. Results: Among 65 patients, 47 of them were male and 18 of them were female. The patients' ages ranged from 48 to 88 years, with an average of 66.26 +/- 8.84 years. In our study, being above the age of 65 (ODDS ratio (OR) 4.65, 95\% CI: 1.61-13.4), male gender (OR 6.75, 95\% CI: 1.71-26.50), smoking (OR 10.50, 95\% CI: 2.15-51.13), the family history (OR 023, 95\% CI: 0.06-0,80), the presence of chronic renal failure (OR 0.41, 95\% CI: 0.30-0.56) were found to increase peripheral artery disease in patients who underwent carotid endarterectomy statistically significant. In cases with low HDL levels, the frequency of peripheral artery disease was found increased. In our study, peripheral artery disease was detected in 30 (46.2\%) of 65 patients who underwent carotid endarterectomy operation. Conclusion: Due to systemic involvement of atherosclerosis, lower extremity peripheral artery disease should be considered in patients who underwent carotid endarterectomy operation, and patients should be evaluated accordingly.Item The Predictive Effects of Clinical Hematological Changes on Saphenous Graft Patency after Coronary Artery Surgery(SOC BRASIL CIRURGIA CARDIOVASC, 2019-01-01) Iyigun, Taner; Kyaruzi, Mugisha Markior; Timur, Baris; Satilmisoglu, Muhammed Hulusi; Iyigun, Muzeyyen; Kaya, MehmetObjectives: To investigate the association between clinical hematologic parameters and saphenous vein graft failure after on-pump coronary artery bypass surgery. Methods: A total of 1950 consecutive patients underwent isolated on-pump coronary artery surgery between November 2010 and February 2013. Of these, 284 patients met our inclusion criteriaItem The Role of Microbiologic Agents in the Progression of the Atherosclerosis: a Comprehensive Review(DIGITAL COMMONS BEPRESS, 2020-01-01) Karabulut, AhmetAtherosclerosis is a leading cause of disability, morbidity and mortality in the world. Atherosclerosis is accepted as a chronic progressive inflammatory disease. The inflammatory cascade in the vascular wall is well-defined. However, the predictors and contributors of the inflammatory response in atherosclerosis are not completely understood. Systemic and local inflammation, which enhance the burden of inflammation in the vascular wall, have been proposed as risk factors for the progression of atherosclerosis. Infectious micro-organisms are one of the major triggering factors for local and systemic inflammation. In this review, we aimed to emphasize the linkage between micro-organisms and the progression of atherosclerosis. We briefly summarize the current medical literature and discuss the future perspectives of the linkage between microbial agents and atherosclerosis representing cause and effect.