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Item The effect of hemodialysis on intraocular pressure(WROCLAW MEDICAL UNIV, 2018-01-01) Kilavuzoglu, Ayse Ebru Bahadir; Yurteri, Gurkan; Guven, Nurgul; Marsap, Savas; Celebi, Ali Riza Cenk; Cosar, Cemile BanuBackground. The effect of hemodialysis (HD) on intraocular pressure (IOP) has been investigated before, but there is a lack of consensus. Clinicians dealing with renal failure patients are interested in the potential negative effects of HD on IOP and the course of glaucoma. Objectives. The aim of this study was to investigate the effects of HD on IOP in patients with end-stage renal disease. Material and methods. This prospective study included 106 patients who were receiving outpatient hemodialysis. Patient history of systemic and ophthalmologic conditions was recorded. Serum osmolality (mOsm), blood urea nitrogen (BUN), blood glucose (BG), bicarbonate (BC), and hematocrit (Hct) levels at the start of HD (pre-HD), at the end of HD (end-HD), and 30 min after HD (post-HD) were measured. Systolic and diastolic blood pressures (SBP and DBP) and IOP were measured at pre-HD, 1-hour intervals during HD, end-HD, and post-HD. Results. A significant decrease in mOsm and BUN and a significant increase in BG, BC, and Hct levels were observed at end-HD (p < 0.05). Mean IOP was 16.71 +/- 2.51 mm Hg at pre-HD, 15.52 +/- 3.18 mm Hg at end-HD, and 15.23 +/- 2.73 mm Hg at post-HD (p = 0.001Item Association Between Serum Pregnancy-Associated Plasma Protein-A and Bicarbonate in Hemodialysis Patients(JOHN WILEY \& SONS INC, 2014-01-01) Bicik, Zerrin; Coskun, Abdurrahman; Serteser, Mustafa; Bulur, Atilla; Mese, Meral; Unsal, IbrahimBackground Acidosis is associated with protein-energy malnutrition, inflammation, and bone disease, and low bicarbonate levels have been implicated in higher mortality rates in chronic kidney disease. Recently, the concentration of serum pregnancy-associated plasma protein-A (PAPP-A) has become accepted as a prognostic marker in hemodialysis patients. This study determined the relationship between PAPP-A and bicarbonate levels in these patients. Methods The study enrolled 65 hemodialysis patients (41 males, 24 females) and 26 control subjects (11 males, 15 females). Serum PAPP-A, intact parathormone (iPTH), calcium, phosphorus (P), and bicarbonate levels were measured. Correlations between PAPP-A and bicarbonate, iPTH, calcium, and phosphorus were evaluated. Results Median PAPP-A levels were significantly higher in hemodialysis patients {[}15.1 (<0.03-158.8) ng/ml] than in control subjects {[}6.6 (<0.03-16.4) ng/ml] (P < 0.05). There were statistically significant correlations between serum PAPP-A and bicarbonate, iPTH, and P in hemodialysis patients but not in control subjects. Conclusion Elevation of serum PAPP-A has been found in hemodialysis patients and its significant correlation with bicarbonate suggests that it may be a prognostic factor.Item Testing the Caregiver Stress Model with the Caregivers of Hemodialysis Patients(ISTANBUL UNIV, FAC LETTERS, DEPT PSYCHOLOGY, 2019-01-01) Aktas, Aysenur; Sertel-Berk, H. OzlemChronic renal failure (CRF) is a long, progressive, and chronic condition that requires care. In hemodialysis treatment, which is the most preferred treatment method in CRF, caregivers (informal caregivers) and health teams (formal caregivers) have difficulties as much as patients during the period of illness, and treatment. The aim of this study is to investigate the caregiving process of hemodialysis patients' informal and formal caregivers within the frame of the ``Caregiver Stress Model{''}. Informal (N = 50, mean of age: 48.5, 92\% of which were woman), and formal (N = 63, mean of age: 33.4, 84\% of which were woman) caregivers from various dialysis units in Istanbul participated in the study. The Resilience Scale for Adults, The Caregiver Well-Being Scale, The Multidimensional Scale of Perceived Social Support, The Ways of Coping Inventory, and the Maslach Burnout Inventory were used. The results showed that the unconfident coping factor of The Ways of Coping Inventory was a moderator of the relationship between the vital activities and personal success which is sub-dimension of Maslach Burnout Inventory was revealed. Also, the findings suggested that resilience, self-confident and unconfident coping factors were significant mediators of the relationships between the vital activities and personal success. The importance of this study is that the caregiver stress model being tested on caregivers of hemodialysis patients has never appeared in the literature before. In the literature, psychological resilience, coping and social support variables, whose formative effects are frequently discussed, contributed to the mediator effects that partially supported the model. Our findings are discussed in light of other published studies in the field.