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Permanent URI for this collectionhttps://hdl.handle.net/11443/932

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Subject: search.filters.subject.obstructive sleep apnea syndrome

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    Investigation of the Effectiveness of Surgical Treatment on Respiratory Functions in Patients With Obstructive Sleep Apnea Syndrome
    (SAGE PUBLICATIONS INC, 2020-01-01) Kersin, Burak; Karaman, Murat; Aynaci, Engin; Keles, Ahmet
    Objective: Obstructive sleep apnea syndrome (OSAS) is a problem that involves many bodily systems and its effects on the respiratory system deserve special attention. Although many studies exist that investigate respiratory functions in patients using continuous positive airway pressure (CPAP) for the treatment of sleep apnea, there is a lack of research regarding the effect of OSAS surgery on respiratory function in the literature, which has motivated us to perform such a study. Materials and Methods: Thirty-two patients diagnosed with OSAS with an apnea hypopnea index ranging between 15 and 30 and had undergone robotic tongue base resection and uvulopharyngoplasty were included as study participants. Pulmonary function tests were performed on all participants 1 day prior to, and at 3 and 6 months after the operation. Weight and body mass indices (BMIs) were also recorded at the same intervals for all participants. Data were electronically recorded and analyzed through SPSS 22.0. Values ofP< .05 have been considered as statistically significant. Results: Average age of the 32 participants was 43.2 +/- 10.7, average body weight was 94.1 +/- 12.6, and average BMI was 31.4 +/- 4.7. Decreases in body weight and BMI values recorded at 3 and 6 months postoperatively had statistical significance when compared with values recorded preoperatively (P< .05). Comparisons made in terms of pulmonary functions revealed a statistically significant increase in 3 and 6-month postoperative values of FVC, FEV1, FEV1/FVC, PEF, and FEF 25-75 (P< .05). Conclusion: Our study shows the positive effects of robotic tongue base resection and uvulopharyngoplasty operation on respiratory function parameters. This suggests that surgical treatment in OSAS patients is as effective as CPAP on respiratory function.
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    Factors Affecting Optimal Titration Pressure of Continuous Positive Airway Pressure Device in Patients with Obstructive Sleep Apnea Syndrome
    (GALENOS YAYINCILIK, 2020-01-01) Kirgezen, Tolga; Bilici, Suat; Cakir, Mustafa; Ceyran, Ozlem; Chasan, Moustafa; Yigit, Ozgur
    Objective: To assess the effects of anatomical, clinical parameters, and pulmonary respiratory function on the therapeutic titration pressure of continuous positive airway pressure (CPAP) device in obstructive sleep apnea syndrome (OSAS). Methods: The study comprised 41 OSAS patients whose optimum CPAP titration pressures were measured. Each patient underwent an otorhinolaryngologic and thoracic examination, and data was recorded for height, weight, body mass index, neck-waist circumferences, Mallampati classification, tonsillar hypertrophy, hypopharyngeal collapse, soft palate-tongue base obstruction scores, peak nasal inspiratory flow and acoustic rhinometry measures, and CPAP device therapeutic pressures. Forced vital capacity, forced expiratory volume, FEV1/FVC ratio and peak expiratory flow values were noted. Results: Median CPAP optimal pressure cut-off value was determined as 9 mmH(2)O. Statistical analysis was made in two groups as CPAP titration optimal pressure <= 9 and >9 mmH(2)O. In the optimal pressure >9 group, neck and waist circumferences, hypopharyngeal collapse score, retropalatal and retrolingual lateral wall collapse scores were significantly higher (p<0.05). In multivariate and univariate model analysis, neck and waist circumferences, hypopharyngeal collapse score, retropalatal and retrolingual lateral wall collapse scores were observed to be significant in predicting high and low pressures in univariate model. Conclusion: For the prediction of optimal CPAP titration pressure in OSAS treatment, wide neck and waist circumferences, high hypopharyngeal collapse score and retropalatal and retrolingual lateral wall collapse grades may be determinative.
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    The Role of Stem Cells in Obstructive Sleep Apnea Syndrome
    (GALENOS PUBL HOUSE, 2015-01-01) Demir, Ceyda Erel Kirisoglu
    Adult stem cells are undifferentiated cells that are present particularly in the bone marrow. Several stimuli, such as inflammation and oxidative stress can mobilize these cells from the bone marrow into the circulating blood and stem cells repair tissue, organ and vascular injuries. Obstructive sleep apnea syndrome is a systemic inflammatory disease with severe cardiovascular consequences. The role of stem cells in obstructive sleep apnea is studied in this review.