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Permanent URI for this collectionhttps://hdl.handle.net/11443/932
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Item Comparison of Qualitative and Volumetric Assessments of Breast Density and Analyses of Breast Compression Parameters and Breast Volume of Women in Bahcesehir Mammography Screening Project(GALENOS YAYINCILIK, 2020-01-01) Gemici, Aysegul Akdogan; Aribal, Erkin; Ozaydin, Ayse Nilufer; Gurdal, Sibel Ozkan; Ozcinar, Beyza; Cabioglu, Neslihan; Ozmen, VahitObjective: We aimed to compare visual and quantitative measurements of breast density and to reveal the density profile with compression characteristics. Materials and Methods: Screening mammograms of 1399 women between May 2014 and May 2015 were evaluated by using Volpara 4th and 5th version. First 379 mammograms were assessed according to ACR BI-RODS 4th- edition and compared to Volpara. We categorized the breast density in two subgroups as dens or non-dens. Two radiologists reviewed the images in consensus. Agreement level between visual and volumetric methods and volumetric methods between themselves assessed using weighted kappa statistics. Volpara data such as fibroglandular volume (FGV), breast volume (BV), compression thickness (CT), compression force (CF), compression pressure (CP) were also analyzed with relation to the age. Results: 1399 mammograms were distributed as follows: 12.7\% VDG1, 39.3\% VDG2, 34.1\% VDG3, 13.9\% VDG4 according to the 4th edition of VolparaItem Evaluation of four different HPLC devices for hemoglobinopathy screening(WALTER DE GRUYTER GMBH, 2021-01-01) Karadag, Mujgan Ercan; Akbulut, Emis Deniz; Avci, Esin; Oguz, Esra Firat; Kader, Saadet; Abusoglu, Gulsum; Serdar, Muhittin; Yamaz, Fatma MericObjective: Hemoglobinopathies are a common public health problem in Turkey. In the screening of these disorders in population, cation-exchange high performance liquid chromatography (HPLC) is accepted as the gold standard method. In this study, the aim was to assess four different HPLC devices used in hemoglobinopathy screening. Materials and methods: A total of 58 blood samples were analyzed with four different HPLC methods (Bio-Rad variant II, Agilent 1100, Tosoh G8 and Trinity Ultra2 trademarks). Results: The comparison study demonstrated a good correlation between the results of each HPLC analyzer and the reference value obtained by averaging all the HbA(2) results belonging to the methods tested in the study {[}(Tosoh G8 (r=0.988), Bio-Rad variant II (r=0.993), Agilent 1100 (r=0.98) and Trinity Ultra2 (r=0.992)]. HbA(2) determination in the presence of HbE was interfered in both BioRad variant II and Tosoh G8. Conclusion: The analyzers were found to have compatible HbA(2) results but with accompanying different degrees of proportional and systematic biases. HPLC analyzers may be affected by different hemoglobin variants at different HbA(2) concentrations, which is an important point to take into consideration during the evaluation of HbA(2) results in thalassemia screening.Item Evaluation of optimal urine screening and confirmation cut-off values for opiates, at a national reference laboratory(WALTER DE GRUYTER GMBH, 2021-01-01) Karakukcu, Cigdem; Ciraci, Mehmet Zahid; Kocer, Derya; Faydali, Mine Yuce; Serdar, Muhittin AbdulkadirObjectives: To obtain optimal immunoassay screening and LC-MS/MS confirmation cut-offs for opiate group tests to reduce false positive (FP) and false negative (FN) rates. Methods: A total of 126 urine samples, -50 opiate screening negative, 76 positive according to the threshold of 300 ng/mL by CEDIA method - were confirmed by a full-validated in-house LC-MS/MS method. Sensitivity, specificity, FP, and FN rates were determined at cut-off concentrations of both 300 and 2,000 ng/mL formorphine and codeine, and 10 ng/mLfor heroinmetabolite 6-mono-acetyl-morphine (6-MAM). Results: All CEDIA opiate negative urine samples were negative for morphine, codeine and 6-MAM. Although sensitivity was 100\% for each cut-offItem Diagnostic Performance of AI for Cancers Registered in A Mammography Screening Program: A Retrospective Analysis(SAGE PUBLICATIONS INC, 2022-01-01) Kizildag Yirgin, Inci; Koyluoglu, Yilmaz Onat; Seker, Mustafa Ege; Ozkan Gurdal, Sibel; Ozaydin, Ayse Nilufer; Ozcinar, Beyza; Cabioglu, Neslihan; Ozmen, Vahit; Aribal, ErkinPurpose: To evaluate the performance of an artificial intelligence (AI) algorithm in a simulated screening setting and its effectiveness in detecting missed and interval cancers. Methods: Digital mammograms were collected from Bahcesehir Mammographic Screening Program which is the first organized, population-based, 10-year (2009-2019) screening program in Turkey. In total, 211 mammograms were extracted from the archive of the screening program in this retrospective study. One hundred ten of them were diagnosed as breast cancer (74 screen-detected, 27 interval, 9 missed), 101 of them were negative mammograms with a follow-up for at least 24 months. Cancer detection rates of radiologists in the screening program were compared with an AI system. Three different mammography assessment methods were used: (1) 2 radiologists' assessment at screening center, (2) AI assessment based on the established risk score threshold, (3) a hypothetical radiologist and AI team-up in which AI was considered to be the third reader. Results: Area under curve was 0.853 (95\% CI = 0.801-0.905) and the cut-off value for risk score was 34.5\% with a sensitivity of 72.8\% and a specificity of 88.3\% for AI cancer detection in ROC analysis. Cancer detection rates were 67.3\% for radiologists, 72.7\% for AI, and 83.6\% for radiologist and AI team-up. AI detected 72.7\% of all cancers on its own, of which 77.5\% were screen-detected, 15\% were interval cancers, and 7.5\% were missed cancers. Conclusion: AI may potentially enhance the capacity of breast cancer screening programs by increasing cancer detection rates and decreasing false-negative evaluations.Item The assessment of autofluorescence of the crystalline lens in diabetic patients and healthy controls: can it be used as a screening test?(DOVE MEDICAL PRESS LTD, 2018-01-01) Pehlivanoglu, Seren; Acar, Nur; Albayrak, Sinan; Karakaya, Muharrem; Ofluoglu, AliBackground: Our purpose was to demonstrate if measuring lens autofluorescence (AF) with a scanning confocal biomicroscope may be used to identify subjects with undiagnosed type II diabetes mellitus (DM), and hence, for it to be used as a marker for the severity of diabetic retinopathy in diabetic patients. Patients and methods: In this cross-sectional, comparative study, lens AF was measured with scanning confocal lens fluorescence biomicroscope in diabetic and healthy groups. Full ophthalmological examination was performed. Blood tests of fasting plasma glucose, and glycosylated hemoglobin were also analyzed. The correlation between lens AF results and blood tests was evaluated in both groups. The cutoff value for the diagnosis of DM using lens AF was investigated. Results: The study included 191 subjects with a mean age of 52.09 +/- 6.75 years. One hundred and seven (56.0\%) subjects were female, and 84 (44.0\%) were male. Eighty-two (42.9\%) patients had type II DM, and 109 (57.1\%) subjects self-reported as normal. The fluorescence ratio (FR) values ranged from 0.09 to 0.46 (0.23 +/- 0.06) in the total group. Mean FR measurements of diabetic subjects were significantly higher (0.27 +/- 0.06) than those without DM (0.20 +/- 0.05), (p=0.001). A statistically significant correlation was found between glycosylated hemoglobin, fasting plasma glucose, and FR. The cutoff point for the FR according to the presence of DM was found to be 0.24 and above (p=0.001), with a sensitivity of 71.95\% and a specificity of 80.73\%. Conclusion: Measuring AF of human lens as an indirect evidence of increased advanced glycaton end products may helpful in detecting impaired glucose metabolism. Our results show highly significant correlation between possibility of DM and FR.Item Thoracic Scoliosis Screening in Adolescent Patients with Chest Radiographs(GALENOS YAYINCILIK, 2019-01-01) Eksi, Murat Sakir; Eksi, Emel Ece OzcanAim: School scoliosis screening programs (SSSPs) are valuable and common tools to depict scoliosis prevalence and to take appropriate measures to prevent scoliosis. Prevalence of small angle scoliosis (10-20 degrees) could be underestimated via SSSPs due to inter-rater variability of the physical examination after which possible candidates are sent to radiographic work-up. In this study, we aimed to detect the prevalence of thoracic scoliosis in adolescent patients via analysis of posteroanterior chest radiographs. Methods: Adolescent patients, who had been admitted for reasons other than spine and whose posteroanterior chest radiographs had been obtained, were included in the study. Demographics and chest radiographs were screened through picture archiving and communication system of the hospital. Results: Chest radiographs of 326 (163 female, 163 male) adolescents were evaluated (mean age: 15.54 +/- 2.12 years