Araştırma Çıktıları

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Author: search.filters.author.Aksoy, Duygu YazganHas files: No

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    Increased Serum Nesfatin-1 Levels in Patients with Impaired Glucose Tolerance
    (GALENOS YAYINCILIK, 2017-01-01) Akin, Safak; Gulcelik, Nese Ersoz; Aksoy, Duygu Yazgan; Karakaya, Jale; Usman, Aydan
    Purpose: Nesfatin-1 is a recently discovered energy-regulating peptide, widely expressed in both central and peripheral tissues. It is involved in various functions, such as the stimulation of hypothalamic-pituitary-adrenal axis and sympathetic nervous system, influencing visceral functions, water intake, and regulation of temperature and emotions. It exerts a direct glucose-dependent insulinotropic action on the beta cells of pancreatic islets. The current study evaluated nesfatin-1 levels and insulin response to glucose load in patients with impaired glucose tolerance (IGT) and in healthy subjects. Material and Method: Of those patients who underwent the oral glucose tolerance test (OGTT), 14 with IGT and 13 body mass index-(BMI) and age-matched healthy subjects as controls were included in the study. Blood samples were taken at 0, 60 and 120 min, and the glucose, insulin, and nesfatin-1 levels were measured. Results: The basal levels of glucose, insulin, and nesfatin-1 were significantly higher in the patients with IGT than in controls. Two-way repeated measures ANOVA revealed that change in time (CIT) for glucose and insulin during an OGTT was significant (p<0.001 and p<0.001, respectively). CIT for glucose and insulin was significantly different between the IGT patients and the controls (p<0.001 and p=0.003, respectively). CIT for nesfatin-1 was not significant (p=0.406) and did not differ significantly between the two groups (p=0.331). Discussion: The elevated levels of basal nesfatin-1 were observed in the patients with IGT. There was no change in the absolute nesfatin-1 levels in response to glucose load in either group. The increase in the levels of basal nesfatin-1 may reflect a compensatory mechanism to regulate the impaired glucose metabolism in the IGT patients, which is later underwhelmed with the onset of diabetes.
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    The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris
    (TERMEDIA PUBLISHING HOUSE LTD, 2020-01-01) Pektas, Suzan Demir; Cinar, Nese; Duman, Deniz Demircioglu; Kara, Ahmet; Batu, Janserey; Karakas-Celik, Sevim; Aksoy, Duygu Yazgan
    Introduction: Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited. Aim: To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris. Material and methods: Thirty-five post-adolescent male patients with a mean age of 28.0 +/- 5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes). Results: Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 +/- 0.06 vs. 0.86 +/- 0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 +/- 5.8 vs. 101.2 +/- 86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups (p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95\% CI: 2.864-43.464, OR = 5.312, 95\% CI: 1.269-22.244, respectively