Araştırma Çıktıları

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Author: search.filters.author.Aksu, MuratHas files: Yes

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    Obstructive Sleep Apnea Syndrome in Acromegaly Before and After Treatment
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Cakir, Ilkay; Bayram, Fahri; Karaca, Zuleyha; Ismailogullari, Sevda; Aksu, Murat
    Introduction: Obstructive sleep apnea syndrome (OSAS) prevalence in acromegaly patients is very common compared with general population. It is thought that OSAS in acromegaly patients evolve because of reversible and irreversible anatomical changes. However, reason of anatomical changes has not been known in present. Maybe, Growth Hormone (GH) and insulin-like growth factor 1 (IGF-I) levels could be an important factor in the development of anatomical changes. In this study, we aimed to determine the prevalence of OSAS in acromegaly and to show the correlation between disease activity and OSAS in acromegalic patients. Materials and Methods: Newly diagnosed and treatment naive 15 acromegaly patients were included into the study. Patients were evaluated by polysomnography (PSG) recordings and hormone levels at baseline and 6 months after treatment. Results: Present study showed that OSAS is more common in patients with acromegaly than general population. Moreover, there is no correlation between GH, IGF-I level and apnea-hipopnea index (AHI) both at baseline and 6 months after treatment. Discussion: OSAS is a condition increased morbidity and mortality associated with acromegaly. Early diagnosis and treatment of acromegaly is important in order to prevent progression of anatomical changes leading to OSAS to an irreversible state. If OSAS and its complications had been prevented, morbidity and mortality in acromegaly patients would have been decreased.
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    Topiramate Induced Restless Legs Syndrome: Case Report
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Aksu, Murat
    Several medications can exacerbate or cause Restless Legs syndrome (RLS). Topiramate is an antiepileptic drug used to epilepsy and migraine treatment. In literature, number of case with topiramate induced RLS is very rare. Herein, we present the case with topiramate induced RLS, in which the case takes to topiramate for migraine prophylaxis. However, how topiramate causes RLS is exactly unknown. Probably, topiramate has an antidopaminergic effect
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    Sleep-Related Eating Disorder (SRED) in a Patient Admitted with Weight Gain Due to Eating Periods During Sleep
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Aksu, Murat
    Sleep related eating disorder (SRED) is classified as a parasomnia seen mostly during non-REM sleep stage. Clinical complications of SRED are obesity and metabolic disease. Although SRED is seen in approximately 5\% of the general population, it is thought that SRED is most often underdiagnosed. Herein, we present a case of SRED.
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    Current Treatment of Willis Ekbom Disease
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Aksu, Murat
    Willis Ekbom Disease (WED) is one of sleep related movements disorders, which is commonly encountered. The treatment of WED has showed many alterations over time. L-dopa is the first dopaminergic agent used to treat to WED, but its use is limited due to adverse effects such as augmentation. Dopamin agonists are the first option in the treatment of WED. These agents are thought to cause less augmentation compared to L-dopa. Of these agents, today, ropinirole, pramipexole and rotigotine have FDA approval. Excessive daytime sleepiness and impulsive control disorders are among important adverse effects. Other agents used to treat WED are alpha 2 delta ligands such as gabapentin, gabapentin enacarbil and pregabalin. Of these, only gabapentin enacarbil has FDA approval for the treatment of WED. Although there are several case reports, augmentation has not been demonstrated related to alpha 2 delta ligands in long term controlled studies. In secondary WED cases, treatment of associated medical conditions also leads to great improvements in WED symptoms.
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    Willis-Ekbom Disease Presenting with Genital Symptoms
    (GALENOS PUBL HOUSE, 2014-01-01) Korkmaz, Selda; Aksu, Murat
    Restless legs syndrome, which recently was coined as Willis-Ekbom disease (WED) is a sleep related movement disorder characterized by an indefinable sense in legs. Rarely, genital restless symptoms may be seen as isolated or accompanied by leg symptoms. Herein, we share a WED case mild leg symptoms and with severe genital symptoms affecting her social life. Genital symptoms have showed improvement by orgasm and L-dopa treatment. Therefore, WED should be considered in differential diagnosis of patients with genital symptoms fulfilling diagnostic criteria of WED defined for restless legs.