Araştırma Çıktıları

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Author: search.filters.author.Alis, DenizHas files: No

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    A Comparative Study of Multiparametric MRI Sequences in Measuring Prostate Cancer Index Lesion Volume
    (UBIQUITY PRESS LTD, 2022-01-01) Bagcilar, Omer; Alis, Deniz; Seker, Mustafa; Erdemli, Servet; Karaarslan, Umut; Kus, Aylin; Kayhan, Cavit; Saglican, Yesim; Kural, Ali; Karaarslan, Ercan
    Objectives: To compare the effectiveness of individual multiparametric prostate MRI (mpMRI) sequences-T2W, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC), and dynamic contrast-enhanced (DCE)-in assessing prostate cancer (PCa) index lesion volume using whole-mount pathology as the ground-truth
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    The Association between the Extent of Late Gadolinium Enhancement and Diastolic Dysfunction in Hypertrophic Cardiomyopathy
    (THIEME MEDICAL PUBL INC, 2021-01-01) Alis, Deniz; Guler, Arda; Asmakutlu, Ozan; Topel, Cagdas; Sahin, Ahmet A.
    Background Diastolic dysfunction in hypertrophic cardiomyopathy (HCM) patients is a frequent, yet poorly understood phenomenon. Purpose The purpose of this study is to assess the relationship between the myocardial fibrosis and diastolic dysfunction in patients with HCM. Materials and Methods We retrospectively investigated the impact of the myocardial fibrosis, as assessed by the extent of late gadolinium enhancement (LGE-\%) on cardiac magnetic resonance imaging (CMRI), on diastolic dysfunction in 110 patients with HCM. The diastolic dysfunction was evaluated by the left atrial (LA) volume index measured on CMRI and lateral septal E/E ratio calculated on echocardiography. Results : There was a moderate correlation between the LGE-\% and LA volume (r = 0.59, p < 0.0001). The logistic regression model of LGE-\%, mitral regurgitation, and total left ventricular mass that investigated the independent predictors of LA volume identified LGE-\% as the only independent parameter associated with the LA volume index (beta = 0.30, p = 0.003). No correlation was observed between the LGE-\% and E/E' (r = 0.24, p = 0.009). Conclusions Myocardial fibrosis in HCM patients is associated with a chronic diastolic burden as represented by increased LA volume. However, the fibrosis does not influence the E/E' ratio, which is a well-known parameter of ventricular relaxation, restoring forces, and filling pressure.