Araştırma Çıktıları

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Author: search.filters.author.Ayas, MeltemHas files: Yes

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    Evaluation of the performance of MALDI-TOF MS and DNA sequence analysis in the identification of mycobacteria species
    (TUBITAK SCIENTIFIC \& TECHNICAL RESEARCH COUNCIL TURKEY, 2018-01-01) Akyar, Isin; Cavusoglu, Cengiz; Ayas, Meltem; Surucuoglu, Suheyla; Ilki, Arzu; Kaya, Deniz Ece; Besli, Yesim
    Background/aim: Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is an alternative way of identifying mycobacteria via the analysis of biomolecules. It is being increasingly used in routine microbiology practice since it permits early, rapid, and cost-effective identification of pathogens of clinical importance. In this study, we aimed to evaluate the efficacy of phenotypic identification of mycobacteria by the MALDI-TOF MS MBT Mycobacteria Library (ML) 4.0 (Bruker, Daltonics) compared to standard sequence analysis. Materials and methods: A total of 155 Mycobacterium clinical and external quality control isolates, comprising nontuberculous mycobacteria (NTM) (n = 95) and the Mycobacterium tuberculosis complex (MTC) (n = 60), were included in the study. Results: Identification by MBT ML4.0 was correctly performed in 100\% of MTC and in 91\% of NTM isolates. All of the MTC isolates were correctly differentiated from NTM isolates. Conclusion: Based on our results, MBT ML4.0 may be used reliably to identify both NTM and MTC.
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    Investigation of ceftazidime-avibactam susceptibility in clinical isolates of gram-negative bacteria
    (Scientific and Technological Research Council Turkey, 2022-01-01) Dumlu, Ridvan; Uyar, Neval Yurttutan; Ayas, Meltem; Aksoy, Nilay; Ozturk, Nur; Kocagoz, Ayse Sesin
    Background/aim: Our study investigated the susceptibility rate of ceftazidime-avibactam and the risk factors associated with its resistance by analyzing gram-negative bacteria isolated from various patient samples. Materials and methods: Between March and November 2020, 1119 gram-negative bacteria strains were isolated from patient samples in Acibadem Healthcare Group hospitals