Araştırma Çıktıları

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    The predictors of COVID-19 mortality in a nationwide cohort of Turkish patients
    (W B SAUNDERS CO LTD, 2021-01-01) Kokturk, Nurdan; Babayigit, Cenk; Kul, Seval; Cetinkaya, Pelin Duru; Nayci, Sibel Atis; Baris, Serap Argun; Karcioglu, Oguz; Aysert, Pinar; Irmak, Ilim; Yuksel, Aycan Akbas; Sekibag, Yonca; Toprak, Oya Baydar; Azak, Emel; Mulamahmutoglu, Sait; Cuhadaroglu, Caglar; Demirel, Aslihan; Kerget, Bugra; Ketencioglu, Burcu Baran; Ozger, Hasan Selcuk; Ozkan, Gulcihan; Ture, Zeynep; Ergan, Begum; Oguz, Vildan Avkan; Kilinc, Oguz; Ercelik, Merve; Ciftci, Tansu Ulukavak; Alici, Ozlem; Temel, Esra Nurlu; Ataoglu, Ozlem; Aydin, Asena; Bahcetepe, Dilek Cetiner; Gullu, Yusuf Taha; Fakili, Fusun; Deveci, Figen; Kose, Neslihan; Tor, Muge Meltem; Gunluoglu, Gulsah; Altin, Sedat; Turgut, Teyfik; Tuna, Tibel; Ozturk, Onder; Dikensoy, Oner; Gulhan, Pinar Yildiz; Basyigit, Ilknur; Boyaci, Hasim; Oguzulgen, I. Kivilcim; Borekci, Sermin; Gemicioglu, Bilun; Bayraktar, Firat; Elbek, Osman; Hanta, Ismail; Okur, Hacer Kuzu; Sagcan, Gulseren; Uzun, Oguz; Akgun, Metin; Altinisik, Goksel; Dursun, Berna; Edis, Ebru Cakir; Gulhan, Erkmen; Eyuboglu, Fusun Oner; Gultekin, Okkes; Havlucu, Yavuz; Ozkan, Metin; Coskun, Aysin Sakar; Sayiner, Abdullah; Kalyoncu, Ali Fuat; Itil, Oya; Bayram, Hasan
    The COVID-19-related death rate varies between countries and is affected by various risk factors. This multi-center registry study was designed to evaluate the mortality rate and the related risk factors in Turkey. We retrospectively evaluated 1500 adults with COVID-19 from 26 centers who were hospitalized between March 11 and July 31, 2020. In the study group, 1041 and 459 cases were diagnosed as definite and highly probable cases, respectively. There were 993 PCR-positive cases (66.2\%). Among all cases, 1144 (76.3\%) were diagnosed with non-severe pneumonia, whereas 212 (14.1\%) had severe pneumonia. Death occurred in 67 patients, corresponding to a mortality rate of 4.5\% (95\% CI:3.5-5.6). The univariate analysis demonstrated that various factors, including male sex, age >= 65 years and the presence of dyspnea or confusion, malignity, chronic obstructive lung disease, interstitial lung disease, immunosuppressive conditions, severe pneumonia, multiorgan dysfunction, and sepsis, were positively associated with mortality. Favipiravir, hydroxychloroquine and azithromycin were not associated with survival. Following multivariate analysis, male sex, severe pneumonia, multiorgan dysfunction, malignancy, sepsis and interstitial lung diseases were found to be independent risk factors for mortality. Among the biomarkers, procalcitonin levels on the 3rd-5th days of admission showed the strongest associations with mortality (OR: 6.18
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    The association of antiviral drugs with COVID-19 morbidity: The retrospective analysis of a nationwide COVID-19 cohort
    (FRONTIERS MEDIA SA, 2022-01-01) Babayigit, Cenk; Kokturk, Nurdan; Kul, Seval; Cetinkaya, Pelin Duru; Nayci, Sibel Atis; Baris, Serap Argun; Karcioglu, Oguz; Aysert, Pinar; Irmak, Ilim; Yuksel, Aycan Akbas; Sekibag, Yonca; Toprak, Oya Baydar; Azak, Emel; Mulamahmutoglu, Sait; Cuhadaroglu, Caglar; Demirel, Aslihan; Kerget, Bugra; Ketencioglu, Burcu Baran; Ozger, Hasan Selcuk; Ozkan, Gulcihan; Ture, Zeynep; Ergan, Begum; Oguz, Vildan Avkan; Kilinc, Oguz; Ercelik, Merve; Ciftci, Tansu Ulukavak; Alici, Ozlem; Temel, Esra Nurlu; Ataoglu, Ozlem; Aydin, Asena; Bahcetepe, Dilek Cetiner; Gullu, Yusuf Taha; Fakili, Fusun; Deveci, Figen; Kose, Neslihan; Tor, Muge Meltem; Gunluoglu, Gulsah; Altin, Sedat; Turgut, Teyfik; Tuna, Tibel; Ozturk, Onder; Dikensoy, Oner; Gulhan, Pinar Yildiz; Basyigit, Ilknur; Boyaci, Hasim; Oguzulgen, Ipek Kivilcim; Borekci, Sermin; Gemicioglu, Bilun; Bayraktar, Firat; Elbek, Osman; Hanta, Ismail; Kuzu Okur, Hacer; Sagcan, Gulseren; Uzun, Oguz; Akgun, Metin; Altinisik, Goksel; Dursun, Berna; Edis, Ebru Cakir; Gulhan, Erkmen; Eyuboglu, Fusun Oner; Gultekin, Okkes; Havlucu, Yavuz; Ozkan, Metin; Coskun, Aysin; Sayiner, Abdullah; Kalyoncu, A. Fuat; Itil, Oya; Bayram, Hasan
    Background and objectivesAlthough several repurposed antiviral drugs have been used for the treatment of COVID-19, only a few such as remdesivir and molnupiravir have shown promising effects. The objectives of our study were to investigate the association of repurposed antiviral drugs with COVID-19 morbidity. MethodsPatients admitted to 26 different hospitals located in 16 different provinces between March 11-July 18, 2020, were enrolled. Case definition was based on WHO criteria. Patients were managed according to the guidelines by Scientific Board of Ministry of Health of Turkey. Primary outcomes were length of hospitalization, intensive care unit (ICU) requirement, and intubation. ResultsWe retrospectively evaluated 1,472 COVID-19 adult patients
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    Evaluation of the relationship between serum ghrelin levels and cancer cachexia in patients with locally advanced nonsmall-cell lung cancer treated with chemoradiotherapy
    (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2020-01-01) Uysal, Pelin; Afsar, Cigdem Usul; Sozer, Volkan; Inanc, Berrin; Agaoglu, Fulya; Gural, Zeynep; Fazlioglu, Nevin Gural; Cuhadaroglu, Caglar; Uzun, Hafize
    Background: Ghrelin plays a role in mechanisms related to cancer progression - including cell proliferation, invasion and migration, and resistance to apoptosis in the cell lines from several cancers. We investigated the role of ghrelin levels in cancer cachexia-anorexia in patients with locally advanced nonsmall-cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). Materials and Methods: This study involved 84 NSCLC patients who had received concomitant CRT. Blood ghrelin levels were compared before and 3 months after CRT. Meanwhile, changes in body weight of the patients were also investigated with changes in ghrelin levels before and after CRT. Results: Ghrelin levels were significantly decreased in line with changes in patients' weights in patients receiving CRT (P < 0.001). Serum albumin levels and inflammatory-nutritional index were significantly decreased after radiotherapy (RT) (3.01 0.40 g/dL, 0.38 +/- 0.20) when compared with its baseline levels (3.40 +/- 0.55 g/dL,P < 0.001
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    Importance of oxidative stress in the evaluation of acute pulmonary embolism severity
    (BMC, 2022-01-01) Sagcan, Gulseren; Konukoglu, Dildar; Uzun, Hafize; Arseven, Orhan; Okumus, Gulfer; Cuhadaroglu, Caglar
    Background Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Our study was aimed to investigate whether oxidative stress markers can be used as clinical markers in the evaluation of acute PE (APE) severity. Methods 47 patients with objectively documented diagnosis of APE were recorded. Of these patients, 14 had low-risk PE, 16 had moderate-risk PE, and 17 had high-risk PE. 21 healthy subjects were also enrolled in this study. Ischemia-modified albumin (IMA), prooxidants-antioxidants balance (PAB), advanced protein oxidation products (AOPPs), and ferric reducing antioxidant power (FRAP) were measured as oxidative stress parameters to evaluate the role of oxidative stress. Results In the low-risk and moderate-risk APE groups, AOPPs and PAB levels were significantly higher and FRAP levels were significantly lower than those in the control group. AOPPs and IMA levels in the patients with high-risk PE were significantly higher than those in both the low-risk and moderate-risk APE patients. There was a significant correlation between levels of AOPPs and the levels of both IMA (r: 0.462, p < 0.001) and PAB (r:0.378, p < 0.005). Serum FRAP levels were negatively correlated with PAB (r:- 0.683, p < 0.001) and AOPPs levels (r:- 0,384, p < 0.001). There was also a significant positive correlation between the serum IMA and PAB levels. Conclusions We clearly demonstrated that reactive oxygen species formation is significantly enhanced in APE. IMA and AOPPs may be used as clinical markers in the evaluation of APE severity in clinical practice. However, further studies with larger patient populations and longer follow-up periods are required to confirm the mechanisms underlying these findings.