Araştırma Çıktıları

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Author: search.filters.author.Duman, Deniz Demircioglu

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    The relationship among androgens, insulin resistance and ghrelin polymorphisms in post-adolescent male patients with severe acne vulgaris
    (TERMEDIA PUBLISHING HOUSE LTD, 2020-01-01) Pektas, Suzan Demir; Cinar, Nese; Duman, Deniz Demircioglu; Kara, Ahmet; Batu, Janserey; Karakas-Celik, Sevim; Aksoy, Duygu Yazgan
    Introduction: Ghrelin has anti-inflammatory and immunomodulatory activities. Data about the role of ghrelin and ghrelin polymorphisms in the development of acne vulgaris in post-adolescent male patients are limited. Aim: To evaluate the role of serum androgens, insulin resistance, ghrelin and ghrelin polymorphisms in severe acne vulgaris. Material and methods: Thirty-five post-adolescent male patients with a mean age of 28.0 +/- 5.4 years and 33 age-and BMI-matched controls were enrolled. Serum androgens, lipids, insulin sensitivity parameters and ghrelin levels were determined. The PCR method was used for GHRL polymorphisms (rs27647, rs696217 and rs34911341 genotypes). Results: Patients had similar anthropometric measures to controls, except a significantly higher WHR in patients (0.92 +/- 0.06 vs. 0.86 +/- 0.08, p < 0.05). Also, FPG, HOMA-IR values, lipid profile and serum androgen levels were similar. Interestingly, patients had significantly lower ghrelin levels than controls (4.5 +/- 5.8 vs. 101.2 +/- 86.5 pg/ml, p < 0.001). The frequencies of rs696217 and rs34911341 genotypes were similar whereas the distribution of rs27647 alleles was significantly different between the groups (p < 0.05). GA and GG genotypes of GHRL rs27647 polymorphism indicated an increased risk of developing acne vulgaris (OR = 11.156, 95\% CI: 2.864-43.464, OR = 5.312, 95\% CI: 1.269-22.244, respectively
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    Is this psoriasis or something else?
    (SCIENTIFIC SCHOLAR LLC, 2022-01-01) Duman, Deniz Demircioglu; Durmaz, Emel Ozturk; Demirkesen, Cuyan; Sahin, Sedef
    A 38-year-old man presented with a history of intractable itchy eruption on the buttocks, present for the last 6 years. The lesions had gradually spread over time and did not respond to several topical steroids. Dermatological examination revealed a butterfly-shaped erythematous verrucous plaque, involving both buttocks and gluteal cleft {[}Figure 1], and peripheral guttate red-brown discrete papules {[}Figure 2]. Histologic examination of a punch biopsy specimen displayed orthokeratosis, follicular plugging, numerous oblique columns of parakeratosis called cornoid lamellae, extending at about 45 degrees from the surface of