Araştırma Çıktıları

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    Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units
    (BMJ PUBLISHING GROUP, 2018-01-01) Bas, Ahmet Yagmur; Demirel, Nihal; Koc, Esin; Isik, Dilek Ulubas; Hirfanoglu, Ibrahim Murat; Tunc, Turan; Sari, Fatma Nur; Karatekin, Guner; Koklu, Esad; Altunhan, Huseyin; Turgut, Hatice; Narter, Fatma; Tarakci, Nuriye; Tekgunduz, Kadir Serafettin; Ozkiraz, Servet; Aydemir, Cumhur; Ozdemir, Ahmet; Cetinkaya, Bilin; Kazanci, Ebru; Tastekin, Ayhan; Calkavur, Sebnem; Ozyurt, Banu Mutlu; Demirelli, Yasar; Asker, Huseyin Selim; Mutlu, Birgul; Uygur, Ozgun; Ozkan, Hilal; Armangil, Didem; Ozlu, Ferda; Mert, Mustafa Kurthan; Ergin, Hacer; Ozcan, Beyza; Bas, Evrim Kiray; Okulu, Emel; Acunas, Betul; Celik, Ulker; Uslu, Sait Ilker; Mutlu, Mehmet; Demir, Nihat; Eroglu, Funda; Gokmen, Zeynel; Beken, Serdar; Bayraktar, Bilge Tanyeri; Hakan, Nilay; Kucuktasci, Kazim; Orman, Aysen; Comert, Serdar; Ertugrul, Sabahattin; Ustun, Nuran; Sahin, Ozlem; Terek, Demet; Kale, Yusuf; Konak, Murat; Yurttutan, Sadik; Aydemir, Ozge; Zenciroglu, Aysegul; Sarici, Dilek; Guzoglu, Nilufer; Hamilcikan, Sahin; Gursoy, Tugba; Tuzun, Funda; Ors, Rahmi; Arslan, Selda; Akdag, Arzu; Memisoglu, Asli; Yasa, Beril; Hekimoglu, Berna; Turan, Ozden; Aylanc, Hakan; Takci, Sahin; Celik, Tolga; Sahin, Suzan; Kilic, Ilknur; Kara, Caner; Tunay, Zuhal Ozen; Celik, Gokhan; Gozen, Ibrahim; Satirtav, Gunhal; Polat, Nihat; Oral, Ayse Yesim; Tokgoz, Mine; Keles, Sadullah; Bilgin, Burak; Ugurbas, Silay Canturk; Karaca, Cagatay; Keskek, Nedime Sahinoglu; Ekinci, Dilbade Yildiz; Balci, Ozlem; Altan, Emir Volkan; Bakbak, Sevda; Ceylan, Nihan Aksu; Kimyon, Sabit; Alyamac, Gunay; Ture, Gamze; Yildiz, Meral; Calis, Feyza; Sizmaz, Selcuk; Sukgen, Emine; Cetin, Ebru Nevin; Ozcimen, Muammer; Demir, Semra Tiryaki; Atila, Huban; Ozal, Altan; Tufaner, Gokhan; Yucel, Ozlem Eski; Kola, Mehmet; Seven, Erbil; Ozdek, Sengul; Durukan, Ali Hakan; Kal, Ali; Celebi, Ali Riza Cenk; Koytak, Ibrahim Arif; Alacamli, Goksu; Esme, Arif; Catak, Onur; Perente, Irfan; Sahin, Alparslan; Akcakaya, Aylin Ardagil; Kiray, Gulunay; Nalcaci, Serhat; Aksoy, Umit; Bakbak, Berker; Comez, Aysegul; Gursoy, Huseyin; Kabatas, Emrah Utku; Petricli, Ikbal Seza; Yumusak, Mehmet Erhan; Kirgiz, Ahmet; Uludag, Gunay; Yaman, Aylin; Dadaci, Zeynep; Karatas, Ali; Celiker, Hande; Cebeci, Zafer; Esenulku, Mahmut Cenap; Akkoyun, Imren; Ersan, Ismail; Demir, Selim; Kadayifcilar, Sibel; Unsal, Ayse Ipek Akyuz; Hocaoglu, Mumin; Grp, T. R.-R.O.P. Study
    Background To evaluate the prevalence, risk factors and treatment of retinopathy of prematurity (ROP) in Turkey and to establish screening criteria for this condition. Methods A prospective cohort study (TR-ROP) was performed between 1 April 2016 and 30 April 2017 in 69 neonatal intensive care units (NICUs). Infants with a birth weight (BW)=1500 g or gestational age (GA)<= 32 weeks and those with a BW> 1500 g or GA> 32 weeks with an unstable clinical course were included in the study. Predictors for the development of ROP were determined by logistic regression analyses. Results The TR-ROP study included 6115 infants: 4964 (81\%) with a GA <= 32 weeks and 1151 (19\%) with a GA>32 weeks. Overall, 27\% had any stage of ROP and 6.7\% had severe ROP. A lower BW, smaller GA, total days on oxygen, late-onset sepsis, frequency of red blood cell transfusions and relative weight gain were identified as independent risk factors for severe ROP in infants with a BW=1500 g. Of all infants, 414 needed treatment and 395 (95.4\%) of the treated infants had a BW <= 1500 g. Sixty-six (16\%) of the treated infants did not fulfil the Early Treatment for Retinopathy of Prematurity requirements for treatment. Conclusions Screening of infants with a GA <= 34 weeks or a BW<1700 g appears to be appropriate in Turkey. Monitoring standards of neonatal care and conducting quality improvement projects across the country are recommended to improve neonatal outcomes in Turkish NICUs.
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    An Uncommon Cause of Hypernatremia in Very Low Birth Weight Premature Infants: Idiopathic Central Diabetes Insipidus
    (AVES, 2021-01-01) Aktas, Selma; Kazanci, Ebru; Semiz, Serap; Korkmaz, Ayse
    Central diabetes insipidus (CDI) is a water homeostasis disorder characterized by an inability to concentrate urine because of insufficient production of antidiuretic hormone. Dehydration with hypernatremia can occur during the neonatal period in preterm neonates in association with insensible water loss, high urine output, and reduced sodium excretion. A high index of suspicion is required to diagnose CDI in preterm neonates. We report two cases, who presented persistent hypernatremia with polyuria despite increased fluid supply and low sodium intake. CDI diagnosis was confirmed by the therapeutic test with oral vasopressin analog. Investigations were all normal