Araştırma Çıktıları

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Author: search.filters.author.Konya, DenizHas files: Yes

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    Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI
    (TURKISH NEUROSURGICAL SOC, 2020-01-01) Eksi, Murat Sakir; Ozcan Eksi, Emel Ece; Arslanhan, Ayca; Sirinoglu, Hakan; Erbil, Sertac; Gungor, Abuzer; Algin, Oktay; Konya, Deniz
    AIM: To learn how rat primary somatosensory cortex (pSSC) responses to the loss of inputs from hind-paw, using fMRI of an inferior magnetic power (1.5 Tesla) with special designed high-powered rat coil. MATERIAL and METHODS: Ten adult male Sprague-Dawley rats were enrolled in this study. The rats were anesthetized with ketamine injection. Xylazine was intraperitoneally injected for analgesia and muscle relaxation with careful maintenance of spontaneous respiration. Either right or left hind-paws were amputated under aseptic conditions according to predefined random allocation of the rats. A 12-channel rat surface coil developed for proper image resolution in 1.5 Tesla MR was used. Functional magnetic resonance imaging was obtained before hind-paw amputation
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    Effects of Parenteral Nutritional Support with Fish-Oil Emulsion on Spinal Cord Recovery in Rats with Traumatic Spinal Cord Injury
    (TURKISH NEUROSURGICAL SOC, 2011-01-01) Emon, Selin Tural; Irban, Arzu Gercek; Bozkurt, Suheyla Uyar; Akakin, Dilek; Konya, Deniz; Ozgen, Serdar
    AIM: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. MATERIAL and METHODS: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically. RESULTS: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p <.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p <.005). Neuronal injury (p <.002) and edema was much more in control group when compared with in group O (p <.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019). CONCLUSION: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.