Araştırma Çıktıları

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Author: search.filters.author.Konya, Deniz

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    Spinal deformity surgery is accompanied by serious complications: report from the Morbidity and Mortality Database of the Scoliosis Research Society from 2013 to 2020
    (SPRINGER, 2022-01-01) Bivona, Louis J.; France, John; Daly-Seiler, Conor S.; Burton, Douglas C.; Dolan, Lori A.; Seale, J. Justin; de Kleuver, Marinus; Ferrero, Emmanuelle; Gurd, David P.; Konya, Deniz; Lavelle, William F.; Sarwahi, Vishal; Suratwala, Sanjeev J.; Yilgor, Caglar; Li, Ying
    Purpose The Morbidity and Mortality (M\&M) report of the Scoliosis Research Society (SRS) has been collected since 1965 and since 1968 submission of complications has been required of all members. Since 2009, the SRS has collected information on death, blindness, and neurological deficit, with acute infection being added in 2012 and unintentional return to the operating room (OR) being added in 2017. In this report, we use the most recent data submitted to the SRS M\&M database to determine the rate of neurological deficit, blindness, acute infection, unintentional return to the OR, and death, while also comparing this information to previous reports. Methods The SRS M\&M database was queried for all cases from 2013 to 2020. The rates of death, vision loss, neurological deficit, acute infection, and unintentional return to the OR were then calculated and analyzed. The rates were compared to previously published data if available. Differences in complication rates between years were analyzed with Poisson regression with significance set at alpha = 0.05. Results The total number of cases submitted per year varied with a maximum of 49,615 in 2018 and a minimum of 40,464 in 2020. The overall reported complication rate from 2013 to 2020 was 2.86\%. The overall mortality rate ranged from 0.09\% in 2018 to 0.14\% in 2015. The number of patients with visual impairment ranged from 4 to 13 between 2013 and 2015 (no data on visual impairment were collected after 2015). The overall infection rate varied from 0.95 in 2020 to 1.30\% in 2015. When the infection rate was analyzed based on spinal deformity group, the neuromuscular scoliosis group consistently had the highest infection rate ranging from 3.24 to 3.94\%. The overall neurological deficit rate ranged from 0.74 to 0.94\%, with the congenital kyphosis and dysplastic spondylolisthesis groups having the highest rates. The rates of unintentional return to the OR ranged from 1.60 to 1.79\%. Multiple groups showed a statistically significant decreasing trend for infection, return to the operating room, neurologic deficit, and death. Conclusions Neuromuscular scoliosis had the highest infection rate among all spinal deformity groups. Congenital kyphosis and dysplastic spondylolisthesis had the highest rate of neurological deficit postoperatively. This is similar to previously published data. Contrary to previous reports, neuromuscular scoliosis did not have the highest annual death rate. Multiple groups showed a statistically significant decreasing trend in complication rates during the reporting period, with only mortality in degenerative spondylolisthesis significantly trending upwards.
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    Functional Reorganization in the Primary Somatosensory Cortex of Rat Following Hind-Paw Amputation: A Study of Functional Imaging with 1.5 Tesla MRI
    (TURKISH NEUROSURGICAL SOC, 2020-01-01) Eksi, Murat Sakir; Ozcan Eksi, Emel Ece; Arslanhan, Ayca; Sirinoglu, Hakan; Erbil, Sertac; Gungor, Abuzer; Algin, Oktay; Konya, Deniz
    AIM: To learn how rat primary somatosensory cortex (pSSC) responses to the loss of inputs from hind-paw, using fMRI of an inferior magnetic power (1.5 Tesla) with special designed high-powered rat coil. MATERIAL and METHODS: Ten adult male Sprague-Dawley rats were enrolled in this study. The rats were anesthetized with ketamine injection. Xylazine was intraperitoneally injected for analgesia and muscle relaxation with careful maintenance of spontaneous respiration. Either right or left hind-paws were amputated under aseptic conditions according to predefined random allocation of the rats. A 12-channel rat surface coil developed for proper image resolution in 1.5 Tesla MR was used. Functional magnetic resonance imaging was obtained before hind-paw amputation
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    Effects of Parenteral Nutritional Support with Fish-Oil Emulsion on Spinal Cord Recovery in Rats with Traumatic Spinal Cord Injury
    (TURKISH NEUROSURGICAL SOC, 2011-01-01) Emon, Selin Tural; Irban, Arzu Gercek; Bozkurt, Suheyla Uyar; Akakin, Dilek; Konya, Deniz; Ozgen, Serdar
    AIM: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. MATERIAL and METHODS: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically. RESULTS: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p <.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p <.005). Neuronal injury (p <.002) and edema was much more in control group when compared with in group O (p <.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019). CONCLUSION: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.