Araştırma Çıktıları

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    Hypopigmented large-cell acanthoma of the eyelid
    (ELSEVIER TAIWAN, 2012-01-01) Mansur, A. Tulin; Aydingoz, Ikbal E.; Kupelioglu, Ali; Cetin, Emel Dikicioglu
    Large-cell acanthoma is an asymptomatic, slightly keratotic, usually hyperpigmented epidermal lesion that is mostly seen in the sun-exposed skin of middle-aged or elderly people. It is characterized by extraordinarily large keratinocytes that can reach up to twice their normal size without a change in the nucleus/cytoplasm ratio. Here, we describe a chronic case of large-cell acanthoma that involved the whole upper eyelid of a 67-year-old man for at least 15 years. The lesion was almost depigmented and demonstrated altered consistency of the eyelid, causing lax and folded skin. The lesion responded to treatment with topical tretinoin and urea. This case verifies the benign character of large-cell acanthoma and demonstrates how it may have atypical presentations. Copyright (C) 2012, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC. All rights reserved.
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    An unusual lesion on the nose: microvenular hemangioma
    (INT DERMOSCOPY SOCIETY, 2018-01-01) Mansur, A. Tulin; Demirci, Gulsen Tukenmez; Koc, Eltaf A. Ozbal; Yildiz, Semsi
    Microvenular hemangioma (MVH) is an acquired, benign type of hemangioma that usually manifests itself as a solitary, slowly growing, red to violaceous, asymptomatic papule, plaque or nodule. It is typically located on the trunk or extremities of young adults. It can be difficult to differentiate MVH from other types of hemangioma and Kaposi sarcoma. Herein we report a case of MVH unusual for its location, age of onset, and morphologic features. A 62-year-old man complained of an asymptomatic, bluish-red discoloration on the tip of his nose that had been present for two years. Dermatologic examination showed a violaceous patch 2 x 2 cm in diameter with indistinct borders. Incisional biopsy revealed irregularly branched small or mediumsized vascular spaces lined with benign endothelial cells, positive for CD34 and negative for HHV-8. MVH is a rare lesion, and less than 70 cases have been published to date. A review of 40 reported cases revealed that 15\% of MVH patients were over 40 years of age and only 3\% of the cases showed macules or patches. A literature survey showed only two cases of MVH located on the facial region, one on the chin and the other on the cheek. Our case was unique for its location and interesting for other rarely encountered features. MVH should be considered in the differential diagnoses of vascular lesions on nasal skin.
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    A case of elephantiasis nostras verrucosa treated successfully by a new type of compressive garment
    (WILEY, 2020-01-01) Mansur, A. Tulin; Ozker, Emre; Demirci, Gulsen Tukenmez
    Elephantiasis nostras verrucosa (ENV) is a clinical manifestation composed of hyperkeratotic, verrucous, and papillomatous lesions and dermal fibrosis, which complicate chronic lymphedema. There is currently no cure for ENV, however, several measures have been used to reduce lymphedema and the resultant pseudoepidermal hyperplasia. Supportive dressings and compression therapy still constitute an important part of the treatment. In this report, we present a 69-year-old male patient with ENV developed due to chronic lymphedema caused by venous insufficiency. After failure of healing with conventional two- and three-layered bandages, and elastic stockings, he was successfully treated by a new type of compression garment. We recommend this user friendly garment for prevention of frictional trauma, contact dermatitis, and secondary infection, which all may complicate compression treatments.