Araştırma Çıktıları

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Author: search.filters.author.Naki, M. MuratHas files: Yes

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    The outcomes of fertility sparing surgery in epithelial ovarian cancer
    (IMR PRESS, 2020-01-01) Karabuk, Emine; Karadag, Burak; Karadag, Ceyda; Kose, M. Faruk; Naki, M. Murat; Guler, E. Nilufer
    Conservative surgery has long been discussed as a treatment option in women with ovarian cancer at reproductive age. However, current guidelines recommend conservative surgery only in selected patients. There is considerable interest on pregnancy and delivery rates after fertility-sparing surgery (FSS), with several ongoing studies on this subject. The aim of the present multi-center study was to evaluate survival and pregnancy outcomes in patients that underwent fertility-sparing surgery. This retrospective study included 19 patients who underwent fertility-sparing surgery due to invasive epithelial ovarian cancer between 2002 and 2014. The median duration of follow-up was 59.5 months (range 10-152 months). A total of 10 full-term pregnancies and 3 spontaneous abortions occurred in 7 patients (36.8\%) following FSS. Ten patients (52.6\%) underwent prophylactic surgery after a median period of 49 months (16-119 months), while 2 patients (10.5\%) developed recurrent disease after prophylactic surgery. Accurate staging in patients with early stage epithelial ovarian cancer and regular follow-up has shown promising reproductive outcomes. In light of the current data, fertility-sparing surgery should be considered in selected patients with stage I epithelial ovarian cancer. There is still no consensus, however, on the selection criteria of eligible patients for fertility-sparing surgery.
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    Microcystic, elongated, and fragmented pattern of invasion in relation to histopathologic and clinical prognostic factors in endometrioid endometrial adenocarcinoma
    (GALENOS YAYINCILIK, 2017-01-01) Naki, M. Murat; Oran, Gulbin; Tetikkurt, Seza Umit; Sonmez, Cavide Fatma; Turkmen, Ilknur; Kose, Faruk
    Objective: To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). Material and Methods: Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The association of MELF pattern with age, tumor grade, depth of myometrial invasion, and presence of lymphovascular space invasion (LVSI) was analyzed. Results: FIGO grade 2 and grade 1 tumors were evident in 53.0\% and 38.6\% of patients, respectively. Depth of myometrial invasion was <50\% in 72.0\% of patients, and LVSI was absent in 77.1\%. MELF pattern was confirmed in 35 (42.2\%) patients. Presence of MELF pattern was associated with significantly higher mean +/- standard deviation age (62.9 +/- 6.9) years vs. 58.9 +/- 9.1 years, p=0.033), and found to be more likely in patients with high-grade tumor (FIGO grade III
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    Is there any difference between the distances created by towel clamp lifting and towel clamp plus manual lifting of the anterior abdominal wall for direct trocar entry in laparoscopic gynecologic surgery? A prospective interventional study
    (GALENOS YAYINCILIK, 2017-01-01) Usta, Taner A.; Karacan, Tolga; Kovalak, Evrim Ebru; Hanli, Ulviye; Naki, M. Murat
    Objective: Most surgeons prefer to perform anterior abdominal wall lifting during abdominal entry to avoid damage to intestines or main vessels. Anterior abdominal wall lifting is assumed to prevent vital organ injuries by creating an adequate distance prior to entry into the peritoneal cavity. In this study, we compared the distance created for trocar entry into the peritoneal cavity with towel clamp lifting and towel clamp plus manual elevation of the anterior abdominal wall. Material and Methods: Forty patients who underwent various laparoscopic procedures were enrolled. The study was performed in two steps: first the anterior abdominal wall was lifted using towel clamps (TC group), next the anterior abdominal wall was lifted via maximal manual elevation from the lower abdomen in addition to towel clamps (TCM group). The insertion distance of a plastic ruler into the abdomen was measured from the parietal peritoneum to the intra-abdominal structure in both groups. Results: There was a statistically significant difference between the two groups (TC group 3.9 +/- 1.5 cm vs. TCM group 4.5 +/- 1.5 cm, p<0.001). Correlation analysis of the relationship of distance with BMI in the study groups revealed a strong negative linear correlation {[}TC group vs. body mass index (BMI)