Araştırma Çıktıları

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Author: search.filters.author.Onal, Mehmet BulentHas files: Yes

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    Azathioprine as a Neuroprotective Agent in Experimental Traumatic Spinal Cord Injury
    (TURKISH NEUROSURGICAL SOC, 2021-01-01) Bahadir, Sinan; Onal, Mehmet Bulent; Narin, Firat; Basar, Ibrahim; Yigitkanli, Kazim; Bavbek, Murad; Ziyal, Mustafa Ibrahim
    AIM: To evaluate the protective effects of azathioprine, a macrophage-inhibiting agent, on secondary injury in spinal cord trauma. MATERIAL and METHODS: A total of 40 Wistar rats were randomly divided into 4 groups. All the animals had undergone T8-10 laminectomy. Except in group I (control), all the animals were exposed to spinal cord trauma at the T9 level. Animals in group II (trauma) received no treatment following trauma. Animals in group 3 (treatment) and group IV (vehicle) were given intraperitoneal azathioprine 4 mg/kg and saline 2 ml, respectively, 30 minutes after the trauma. Half of the animals in each group were sacrificed 24 hours after injury and specimens were used for biochemical and immunohistochemical evaluations. The rest of the animals were followed-up for 4 weeks in terms of neurological functions and were also sacrificed to perform the histopathological analysis. RESULTS: Significant decrease in apoptotic cells and improved neurological function were observed in the animals treated with azathioprine. Biological and immunohistochemical analysis also showed less oxidative stress in this group compared to those without treatment. CONCLUSION: Azathioprine, a potent macrophage-inhibiting agent, has been shown to decrease the extent of secondary injury following spinal cord trauma.
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    The C2-Pars Interarticularis Screw as an Alternative in Atlanto-Axial Stabilization. A Biomechanical Comparison of Established Techniques
    (TURKISH NEUROSURGICAL SOC, 2018-01-01) Schleicher, Philipp; Onal, Mehmet Bulent; Hemberger, Frank; Scholz, Matti; Kandziora, Frank
    AIM: To compare four different atlantoaxial stabilization techniques. MATERIAL and METHODS: Eight human cervical spines (segments C0-C3) were tested in flexion/extension, lateral bending and axial rotation. Range of Motion (ROM) at a 1.5 Nm load was recorded. After native testing, the Harms (HARMS), pars screw (PARS), intralaminar screw (INTRA) and anterior transarticular screw (ATA) constructs were applied in a random order. RESULTS: FLEXION/EXTENSION: mean ROM (+/- SD) in native state was 15.9 degrees (+/- 7.6 degrees)