Araştırma Çıktıları

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Author: search.filters.author.Ozkan, BernaHas files: Yes

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    Impact of Intravitreal Dexamethasone Implant on Vessel Diameters in Patients with Retinal Vein Occlusion
    (HINDAWI LTD, 2019-01-01) Tugan, Busra Yilmaz; Karabas, Levent; Ozkan, Berna
    Purpose. To investigate the vasomotor responses and diameter of retinal vessels in patients with macular edema secondary to retinal vein occlusion (RVO) who were treated with intravitreal dexamethasone implant. Methods. We enrolled 17 eyes of 17 patients with macular edema secondary to RVO. All patients were evaluated through optical coherence tomography and dynamic and static retinal vessel analysis, using the Dynamic Vessel Analyzer (Imedos, Jena, Germany) before administration (baseline) and 1week, 1month, and 2months after administration of intravitreal dexamethasone. Measurements of patients were compared to those of 17 eyes of age- and sex-matched control subjects. Results. In static analysis, arteriovenous ratio (AVR) in control subjects was 0.86 (0.80-0.88). In RVO patients, baseline AVR was 0.71 (0.54-0.84) and significantly lower than that in control subjects (p=0.016). Baseline AVR in the RVO group was significantly lower than AVR at month 1 and month 2 (p=0.001 and p<0.001, respectively). CRVE in healthy control subjects was 183.59 +/- 21.79 measurement units (MU) which was significantly different from CRVE of RVO eyes at baseline (207.00 +/- 26.35MU) (p=0.008). Static analysis showed a significant decrease of central retinal vein equivalent (CRVE) from baseline to 1week, 1month, and 2months (p<0.001, p<0.001, and p<0.001, respectively). CRAE in the control group was 176.24 +/- 22.45MU. CRAE in the RVO group was significantly lower at baseline, week 1, month 1, and month 2 compared to that in the control group (p=0.008, p=0.003, p=0.013, and p=0.011, respectively). Dynamic analysis showed that maximum venous and arterial dilations did not statistically differ from baseline to 1week, 1month, or 2months. Conclusion. Using the Dynamic Vessel Analyzer, we found that retinal veins in patients with RVO were significantly larger compared to those in the control group, and intravitreal dexamethasone treatment reduced the diameters of these veins.
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    Limited Vitrectomy in Patients with Idiopathic Macular Hole
    (GALENOS PUBL HOUSE, 2019-01-01) Ozkan, Berna; Karabas, Veysel Levent; Tugan, Busra Yilmaz; Altintas, Ozgul
    Background: Partial posterior hyaloidectomy is suggested to minimize traction on the vitreous base and thus reduce the risk of iatrogenic breaks in patients with macular hole and epiretinal membrane. Aims: To evaluate the safety and efficacy of limited vitrectomy in patients with macular hole. Study Design: Retrospective cohort study. Methods: Fifty-two consecutive patients who underwent macular hole surgery without complete peripheral vitreous removal were included in the study. The improvement in visual acuity, the incidence of retinal breaks and detachment, anatomical results, and intraoperative and postoperative complications of this technique were evaluated. Results: The median visual acuity was 0.2 (0.1-0.4) before surgery and 0.5 (0.3-0.6) after surgery (p<0.001). None of the patients had retinal breaks or detachments. A sulfur hexafluoride was used in 24 patients (46.2\%), and perfluoropropane was used in 28 patients (53.8\%). Three patients (5.76\%) had revision surgery because of recurrence of the macular hole. We did not observe proliferative vitreoretinopathy or surgery-related major complications in any patient during the follow-up period. Conclusion: Limited vitrectomy without removal of the peripheral vitreous seems to be effective and safe with minimal risk of peripheral retinal breaks and detachment.