Araştırma Çıktıları

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Author: search.filters.author.Selam, Belgin

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    Early Compaction Might Be a Parameter to Determine Good Quality Embryos and Day of Embryo Transfer in Patients Undergoing Intracytoplasmic Sperm Injection
    (CUREUS INC, 2022-01-01) Ozturk, Senem Aslan; Cincik, Mehmet; Cakil, Yaprak Donmez; Sayan, Sena; Selam, Belgin
    Introduction: Compaction is the first event in embryo morphogenesis. Blastocyst transfer on day five or six has been widely performed in the last decade. We investigated the clinical value of early compaction on day three for evaluation of the transferred embryo quality and pregnancy. Methods: Four hundred patients with female factor infertility and 776 fresh embryo transfers were included. Two groups were formed: Early compaction group had embryo transfer with at least one day-three embryo exhibiting early compaction. Transferred embryos without early compaction comprised the control group. Embryo transfer was performed on day three or five after the assessment of embryo compaction by a time-lapse technology system. Each patient underwent only a single cycle of embryo transfer. We analyzed fertilization, pregnancy, and live birth rates. Results: We detected significantly higher numbers of the retrieved oocytes, metaphase II (MII) oocytes, and fertilized oocytes in the early compaction group. Moreover, the transfer of the early compacting embryos on day three resulted in higher pregnancy and live birth rates. Conclusion: Our data suggest that early compaction might be a factor to determine good quality embryos and embryo transfer day.
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    Rescue IVM of Denuded GV- and MI-Stage Oocytes of Premenopausal Rats with Oncostatin M, Insulin-like Growth Factor I, and Growth Hormone
    (MDPI, 2022-01-01) Akdemir, Yesim; Donmez Cakil, Yaprak; Selam, Belgin; Sitar, Mustafa Erinc; Cincik, Mehmet
    Immature oocytes are retrieved and matured through in vitro maturation (IVM). Maturation, fertilization rates, and embryo development via IVM are all lower than those found in vitro fertilization (IVF) cycles. We investigated the effects of oncostatin M (OSM), insulin-like growth factor-1 (IGF-I), and growth hormone (GH) in rescue IVM. A total of 111 germinal vesicle (GV) and 17 metaphase I (MI) oocytes were obtained after conventional IVF from 28 female Wistar albino rats. Denuded immature oocytes were cultured in maturation medium supplemented with OSM, IGF-1, or GH. The quantities of metaphase II (MII) oocytes matured from the GV stage were 17 of 30 (56.6\%), 15 of 28 (53.5\%), 10 of 30 (33.3\%), and 7 of 23 (30.3\%), in control, OSM, IGF-I, and GH groups, respectively. Maturation rates in control and OSM groups were higher than those in IGF-I and GH groups (p = 0.001). The quantities of MII oocytes matured from MI stage were 7 of 7 (100\%), 4 of 4 (100\%), 1 of 1 (100\%), and 1 of 5 (20\%) in control, OSM, IGF-I, and GH groups, respectively. Maturation rates from MI to MII stages in control, OSM, and IGF-I groups were higher than those in the GH group (p = 0.004). Acceptable maturation rates are observed with OSM in rat oocytes in rescue IVM.
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    Sperm Selection and Embryo Development: A Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods in Patients with Astheno-Teratozoospermia
    (MDPI, 2021-01-01) Guler, Cagla; Melil, Sureyya; Ozekici, Umit; Donmez Cakil, Yaprak; Selam, Belgin; Cincik, Mehmet
    In recent years, microfluidic chip-based sperm sorting has emerged as an alternative tool to centrifugation-based conventional techniques for in vitro fertilization. This prospective study aims to compare the effects of density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in patient populations with astheno-teratozoospermia. In the study, the semen samples of the patients were divided into two groups for preparation with either the microfluidic or density gradient methods. Selected spermatozoa were then used to fertilize mature sibling oocytes and the semen parameters and embryo development on days 3 and 5 were assessed. While the density gradient group was associated with a higher sperm concentration, motility (progressive and total) was significantly higher in the microfluidic chip group. No significant differences were observed in the fertilization rates or grade 1 (G1) and grade 2 (G2) proportions of the third-day embryos. Furthermore, while the proportions of the poor, fair and good blastocysts on day 5 did not differ significantly, excellent blastocysts (indicating high-quality embryos) were observed in a significantly higher proportion of the microfluidic chip group. When compared to the classical density gradient method, the microfluidic chip sperm preparation yielded sperm with higher motility and higher quality blastocysts at day 5
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    Schwannoma of the clitoris: a case report
    (IMR PRESS, 2021-01-01) Kocak, Alper; Selam, Belgin; Akar, Eylem; Erkanli, Serkan
    Schwannoma (neurilemoma or neurinoma) is a tumor that develops from the Schwann cells in the myelin sheath of the peripheral nerves. It is most commonly observed on the head, neck, upper and lower extremities, posterior mediastinum and retroperitoneum. Schwannomas are rarely found in the external female genitalia. To the best of our knowledge, only 6 cases of clitoral schwannoma have been reported in medical literature. We currently report the case of a 46-year-old woman who was presenting with a 3 X 2 cm, painless mass in her clitoris for the past two years. She has no history of neurofibromatosis. Surgical excision of the mass was undertaken. Histopathology and immunohistochemistry revealed schwannoma of the clitoris. No evidence of local recurrence was noted after 6 months of follow-up. We are reporting the current patient because of the rare location of schwannoma. In the present case report, clinical features, treatment guidelines, diagnostic features and the immunohistochemical characteristics of this tumor are reviewed.
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    Transient osteoporosis of pregnancy: case report
    (GALENOS YAYINCILIK, 2010-01-01) Ergin, Tolga; Selam, Belgin; Lembet, Arda; Ozturk, Harika Bodur; Damlacik, Atilla; Demirel, Cem
    Transient osteoporosis of pregnancy is a rarely observed skeletal pathology developing in the last months of pregnancy. Meticulous evaluation is important for the differential diagnosis of severe and progressive hip and/or groin pain in pregnant patients. MRI is a valuable and safe technique for demonstrating bone marrow edema and skeletal abnormalities during pregnancy. Avoidance of vaginal delivery and non-weight bearing measures are essential in order to prevent complications such as hip fractures related to transient osteoporosis of pregnancy. We present the diagnostic evaluation and treatment of an uncommon case of transient osteoporosis of pregnancy with resolution of symptoms and postpartum.