Araştırma Çıktıları

Permanent URI for this communityhttps://hdl.handle.net/11443/931

Browse

Filters

2014 - 201912020 - 20213

Settings

Author: search.filters.author.Tumay, Latif Volkan

Search Results

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Persistent extramural vascular invasion positivity on magnetic resonance imaging after neoadjuvant chemoradiotherapy predicts poor outcome in rectal cancer
    (ELSEVIER SINGAPORE PTE LTD, 2021-01-01) Guner, Osman Serhat; Tumay, Latif Volkan
    Background: In rectal cancer, extramural vascular invasion (EMVI) is the presence of tumour cells in blood vessels outside the muscular layer, which is associated with poor prognosis. Regression of EMVI on MRI following neoadjuvant chemoradiotherapy or its persistence may have prognostic implications. Methods: This retrospective study included 52 patients with rectal cancer who underwent total mesorectal excision following long-course neoadjuvant chemoradiotherapy (CRT). EMVI assessments were done on previous pelvic MRIs obtained before neoadjuvant CRT and eight weeks after the completion of neoadjuvant chemoradiotherapy in initially EMVI positive cases. Results: Persistently EMVI positive patients had worse overall survival and disease-free survival compared to initially EMVI negative patients and patients who returned to negative (p < 0.001 for both). Multivariate analysis identified persistent EMVI positivity after neoadjuvant treatment (HR, 102.9
  • Thumbnail Image
    Item
    Turnbull-Cutait technique without ileostomy after total mesorectal excision is associated with acceptably low early post-operative morbidity
    (WILEY, 2021-01-01) Guner, Osman Serhat; Tumay, Latif Volkan
    Background: This study aimed to compare the standard one-stage coloanal anastomosis (CAA) technique plus diverting ileostomy and the Turnbull-Cutait (T-C) technique with delayed CAA in terms of early post-operative morbidity in patients with low rectal cancer. Methods: A total of 33 patients with non-metastatic distal rectal cancer who were operated with one of the two different reconstruction methods (one-stage CAA plus diverting ileostomy or two-stage T-C technique with delayed CAA) after total mesorectal excision were included in this retrospective study. The two groups were compared for early postoperative morbidity within 30 post-operative days using complication frequency, Clavien-Dindo classification and Comprehensive Complication Index scores. Results: The two groups did not differ in terms of morbidity parameters, including frequency of any morbidity, presence of grade 3b morbidity requiring management under general anaesthesia, as well as Comprehensive Complication Index score (P > 0.05 for all). Conclusion: Our findings suggest that the two techniques did not differ in terms of early post-operative morbidity. Owing to its comparable morbidity and safety to CAA plus concomitant ileostomy performed at the same session, the T-C technique may be considered in distal rectal cancer patients refusing to have a temporary stoma and in patients in whom CAA poses technical difficulties during the initial operation.
  • No Thumbnail Available
    Item
    Availability of totally implantable venous access devices in cancer patients is high in the long term: a seven-year follow-up study
    (SPRINGER, 2021-01-01) Tumay, Latif Volkan; Guner, Osman Serhat
    Purpose Totally implantable venous access devices (TIVADs) currently have an important place in medical oncology practice
  • No Thumbnail Available
    Item
    Serum Annexin A2 Levels in Patients with Colon Cancer in Comparison to Healthy Controls and in Relation to Tumor Pathology
    (INT SCIENTIFIC INFORMATION, INC, 2014-01-01) Gurluler, Ercument; Guner, Osman Serhat; Tumay, Latif Volkan; Kucukmetin, Nurten Turkel; Hizli, Banu; Zorluoglu, Abdullah
    Background: The deregulation and localization of the Annexins is consistently reported to have close relation to tumor cell malignancy, invasion, and metastasis as well as clinical progression of tumors. This study aimed to evaluate serum Annexin A2 (Anx A2) levels in patients with colon cancer in comparison to healthy controls and in relation to demographics and tumor pathology. Material/Methods: A total of 100 patients (mean (SD) age: 58 (5.8) years, 55.0\% females) with colon cancer and 70 controls (mean (SD) age: 59 (5.4) years, 50.0\% females) were included. Serum levels for Anx A2 were evaluated in relation to study group, demographics, and tumor pathology. Results: Serum levels for Anx A2 were significantly lower in patients with colon cancer than in controls (13.1 (4.5) vs. 22.8 (2.1) ng/mL, p<0.001) and significantly decreased with increase in tumor size (p=0.003), and at higher stages of TNM (p=0.004), tumor invasion (p=0.005), lymph node metastasis (p=0.003), and distant metastasis (p=0.005). Conclusions: Our findings indicate a significant decrease in Anx A2 expression in colon cancer patients compared to healthy controls and in parallel with tumor progression.