Araştırma Çıktıları

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Author: search.filters.author.Tutuncu, MelihHas files: No

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    The Socioeconomic and Psychological Impact of the COVID-19 Pandemic on People with Multiple Sclerosis in Turkey
    (TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI DERNEGI, 2022-01-01) Gunduz, Tuncay; Uzunkopru, Cihat; Demir, Serkan; Tutuncu, Melih; Seferoglu, Meral; Gumus, Haluk; Sen, Sedat; Gungor Dogan, Ipek; Tutuncu, Mesude; Solak Calikoglu, Yasemin; Beckmann, Yesim; Sagduyu Kocaman, Ayse; Siva, Aksel
    Introduction: Various restrictions due to the coronavirus infection have affected working life globally. People with multiple sclerosis (pwMS) have several difficulties in social life, patient follow-up, and receiving treatments. In this study, we aimed to evaluate the experiences of pwMS during the COVID-19 pandemic. Method: We developed a 50-question survey aiming to determine fears, anxieties, and the problems experienced by patients regarding their diseases and social lives during the COVID-19 pandemic. The questionnaire was released online via the Turkish MS Society website, local MS societies websites, and social media accounts. Only the answers of the patients who filled out the questionnaire completely were evaluated. Results: In total, 6008 patients took the survey, and 3255 of them completed the questionnaire. Among all, 378 patients (11.6\%) were positive for COVID-19. The most common COVID-19-related symptom was fatigue (48.4\%). The routine medical follow-up was interrupted in 61.4\% and the medication was discontinued in 14\% of the patients. Approximately 25\% of the patients reported different symptoms related to relapse activity. The main concern of the patients related to the COVID-19 pandemic was the disruption of the health of the ones they loved. Among all the patients, 4.4\% lost their jobs. Conclusion: Our data showed that the COVID-19 pandemic strongly affected the working lives of pwMS. Also, the pandemic changed the attitudes of patients and neurologists. Therefore, the long-term effects of the COVID-19 pandemic on disease approach, patient follow-up, social conditions, and working life should be monitored.
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    Investigating the role of common and rare variants in multiplex multiple sclerosis families reveals an increased burden of common risk variation
    (NATURE PORTFOLIO, 2022-01-01) Everest, Elif; Ahangari, Mohammad; Uygunoglu, Ugur; Tutuncu, Melih; Bulbul, Alper; Saip, Sabahattin; Duman, Taskin; Sezerman, Ugur; Reich, Daniel S.; Riley, Brien P.; Siva, Aksel; Turanli, Eda Tahir
    Many multiple sclerosis (MS)-associated common risk variants as well as candidate low-frequency and rare variants have been identified
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    Investigation of multiple sclerosis-related pathways through the integration of genomic and proteomic data
    (PEERJ INC, 2021-01-01) Everest, Elif; Ulgen, Ege; Uygunoglu, Ugur; Tutuncu, Melih; Saip, Sabahattin; Sezerman, Osman Ugur; Siva, Aksel; Turanli, Eda Tahir
    Background. Multiple sclerosis (MS) has a complex pathophysiology, variable clinical presentation, and unpredictable prognosis