Araştırma Çıktıları

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    Differential gene expression analysis of human cumulus cells
    (KOREAN SOC REPRODUCTIVE MEDICINE, 2019-01-01) Demiray, Sirin Bakti; Goker, Ege Nazan Tavmergen; Tavmergen, Erol; Yilmaz, Ozlem; Calimlioglu, Nilufer; Soykam, Huseyin Okan; Oktem, Gulperi; Sezerman, Ugur
    Objective: This study was performed to explore the possibility that each oocyte and its surrounding cumulus cells might have different genetic expression patterns that could affect human reproduction. Methods: Differential gene expression analysis was performed for 10 clusters of cumulus cells obtained from 10 cumulus-oocyte complexes from 10 patients. Same procedures related to oocyte maturation, microinjection, and microarray analyses were performed for each group of cumulus cells. Two differential gene expression analyses were performed: one for the outcome of clinical pregnancy and one for the outcome of live birth. Results: Significant genes resulting from these analyses were selected and the top 20 affected pathways in each group were analyzed. Circadian entrainment is determined to be the most affected pathway for clinical pregnancy, and proteoglycans in cancer pathway is the most affected pathway for live birth. Circadian entrainment is also amongst the 12 pathways that are found to be in top 20 affected pathways for both outcomes, and has both lowest p-value and highest number of times found count. Conclusion: Although further confirmatory studies are necessary, findings of this study suggest that these pathways, especially circadian entrainment in cumulus cells, may be essential for embryo development and pregnancy.
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    Spontaneous rupture of a splenic artery aneurysm during the third trimester of pregnancy
    (WALTER DE GRUYTER GMBH, 2017-01-01) Peker, Nuri; Vicdanli, Nazif Harun; Demir, Ahmet; Bozan, Mehmet Bugra; Gundogan, Savas
    Spontaneous rupture of a splenic artery aneurysm (SAA) during pregnancy is a rare but life-threatening situation typically presenting with sudden and unexpected fetal and maternal death. The etiology is unclear